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Patients nearing end of life may not feel abandoned after discontinuation of cholesterol medications

New research suggests patients nearing the end of their lives because of a "life-limiting illness" such as cancer or heart disease may not feel medically abandoned if their doctor wants to take them off the statins that control their cholesterol.

2 Jun 2017

Recommendations to facilitate optimal CGM use and reporting of data in diabetes clinical research

The advantages of continuous glucose monitoring (CGM) for obtaining real-time blood glucose measurements and its ability to detect and even predict hypo- and hyperglycemic events make it a very useful tool for evaluating experimental glucose-lowering drugs and new approaches for treating diabetes.

2 Jun 2017

Scientists locate crucial off-switch for central cell control

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes array.

2 Jun 2017

Scientists create new method to make peptide stapling widely available

UK scientists have created a new method to structure peptides, which they say will be cheaper and make the process of using stapled peptides in drug discovery much more widely available.

2 Jun 2017

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

Researchers at the Novo Nordisk Foundation Center for Biosustainability in Denmark have developed a method of producing P450 enzymes - used by plants to defend against predators and microbes - in bacterial cell factories. The process could facilitate the production of large quantities of the enzymes, which are also involved in the biosynthesis of active ingredients of cancer drugs.

2 Jun 2017

As government-funded cancer research sags, scientists fear U.S. is ‘losing its edge’

Less and less of the research presented at a prominent cancer conference is supported by the National Institutes of Health, a development that some of the country's top scientists see as a worrisome trend.

2 Jun 2017

UCSB biologists develop new antimicrobial susceptibility test to transform the way antibiotics are tested

When a patient is prescribed the wrong antibiotic to treat a bacterial infection, it's not necessarily the physician who is at fault. The current antibiotic assay -- standardized in 1961 by the World Health Organization and used worldwide -- is potentially flawed.

2 Jun 2017

Yale scientists develop novel chemical process that may lead to creation of new antibiotics

Yale University scientists have developed a novel chemical process that may lead to the creation of a new class of antibiotics.

1 Jun 2017

Tobacco use more common among HIV positive individuals, York study shows

Researchers at the University of York have shown that tobacco use is more common among HIV positive individuals than HIV negative individuals.

1 Jun 2017

Scientists discover unexpected mechanism behind chronic nerve pain

It has long been assumed that chronic nerve pain is caused by hypersensitivity in the neurons that transmit pain.

1 Jun 2017

Antidepressant use during pregnancy not linked to newborn problems at 2-4 weeks after birth

Babies exposed to an antidepressant or a mood disorder during fetal life did not have any more signs of irritability, difficulty feeding, sleep disturbances and respiratory problems two to four weeks after birth than babies who were not exposed.

1 Jun 2017

Researchers discover new class of compounds that inhibit bacterial DNA gyrase

An international team of scientists have discovered a new class of compounds that inhibit bacterial DNA gyrase.

1 Jun 2017

Innocuous start to opioid addition: A 1980 letter that started it all

In a letter to the Editor published this Wednesday (31st May 2017), a group of Canadian researchers have disclosed how a sting of words coming from a notable doctor nearly 4 decades ago was the seed that led to a nationwide epidemic of misuse and abuse of opioid painkiller drugs such as Vicodin and OxyContin.

1 Jun 2017

Insilico Medicine launches personalized drug discovery platform to develop new treatments for ALS

Today, Insilico Medicine, Inc., a company applying the latest advances in deep learning to biomarker development, drug discovery and aging research, launched ALS.AI, a personalized drug discovery and biomarker development platform utilizing the latest advances in deep learning.

1 Jun 2017

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

A study led by Columbia University Medical Center has shown that chronic pain may occur when pain receptors migrate from the nerve cell's surface to the cell's inner chambers, out of the reach of current pain medications.

1 Jun 2017

Cholesterol shown to have clear effect on lung surface properties

Cholesterol, a naturally occurring compound at the lung surface, has been shown to have a clear effect on the properties of this nanoscale film that covers the inside of our lungs.

1 Jun 2017

Survey finds wide variation in hepatitis B, C testing policy and practice across the EU/EEA

The survey results suggest a wide variation in existing national testing policy and practice when it comes to hepatitis B and C - with overall limited monitoring of testing, diagnosis, and treatment across EU/EEA Member States.

1 Jun 2017

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

By adding an experimental drug to a standard chemotherapy regimen, a subset of patients with metastatic pancreatic cancer had a significantly longer period before the cancer progressed as compared with those who received the standard treatment, according to a Phase 2 clinical trial led by an investigator at Fred Hutchinson Cancer Research Center.

1 Jun 2017

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Subgroups of tuberculosis (TB)-causing bacteria can persist even when antibiotics wipe out most of the overall population. The need to eliminate these persistent subpopulations is one reason why TB treatment regimens are so lengthy.

1 Jun 2017

Repeated exposure to anesthesia early in life impairs visual recognition memory

Repeated exposure to a common anesthesia drug early in life results in visual recognition memory impairment, which emerges after the first year of life and may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai and published online May 31 in the British Journal of Anaesthesia.

31 May 2017

Drugs News and Research

Patients nearing end of life may not feel abandoned after discontinuation of cholesterol medications

Recommendations to facilitate optimal CGM use and reporting of data in diabetes clinical research

Scientists locate crucial off-switch for central cell control

Scientists create new method to make peptide stapling widely available

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

As government-funded cancer research sags, scientists fear U.S. is ‘losing its edge’

UCSB biologists develop new antimicrobial susceptibility test to transform the way antibiotics are tested

Yale scientists develop novel chemical process that may lead to creation of new antibiotics

Tobacco use more common among HIV positive individuals, York study shows

Scientists discover unexpected mechanism behind chronic nerve pain

Antidepressant use during pregnancy not linked to newborn problems at 2-4 weeks after birth

Researchers discover new class of compounds that inhibit bacterial DNA gyrase

Innocuous start to opioid addition: A 1980 letter that started it all

Insilico Medicine launches personalized drug discovery platform to develop new treatments for ALS

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

Cholesterol shown to have clear effect on lung surface properties

Survey finds wide variation in hepatitis B, C testing policy and practice across the EU/EEA

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Repeated exposure to anesthesia early in life impairs visual recognition memory

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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