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Scientists uncover bacterial cloaking

Scientists have uncovered the workings of a method bacteria responsible for diseases such as meningitis and blood disorders use to hide from the body's immune system.

2 Apr 2007

New insights into melatonin production

In the April 1 issue of G&D, a Korean research team led by Dr. Kyong-Tai Kim (Pohang University) describes how melatonin production is coordinated with the body's natural sleep/wake cycles.

2 Apr 2007

Revving up a crucial set of muscle genes improves muscular dystrophy symptoms in mice

Scientists at Dana-Farber Cancer Institute have shown in a laboratory study that revving up a crucial set of muscle genes counteracts the damage caused by a form of muscular dystrophy.

2 Apr 2007

New target for removing unwanted ammonia from the body

Thousands of people with liver and kidney disease die every year from too much ammonia in their blood, and scientists from the United States and Japan have found a possible solution.

2 Apr 2007

Scientists create small molecules to probe proteins deep inside cell membrane

Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules.

2 Apr 2007

Glyoxalase I protects proteins against damage by oxidation and nitration

Protein degradation and malfunction is a major cause of ageing and can be the result of attacks on proteins by other molecules.

2 Apr 2007

Possible therapeutic target for Duchenne muscular dystrophy

In the April 1st issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues identify a key genetic component of and possible therapeutic target for Duchenne muscular dystrophy.

2 Apr 2007

Estrogen improves host response after traumatic injury

Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage.

2 Apr 2007

Pseudoknots an important step in developing a viral vaccine

How is virus as for example HIV and bird flu able to make the cells within a human body work for the purpose of the virus?

2 Apr 2007

Potential new cancer diagnosis and treatment options

By recognizing sugars, a technique developed by University of Michigan analytical chemist Kristina Hakansson sets the stage for new cancer diagnosis and treatment options.

2 Apr 2007

Iron nanoparticles exhibit toxic effects on neuronal cells

Researchers at UC San Diego have discovered that iron-containing nanoparticles being tested for use in several biomedical applications can be toxic to nerve cells and interfere with the formation of their signal-transmitting extensions.

1 Apr 2007

Next generation drugs designed from 3D protein models

The next generation of drugs will be designed on the basis of 3D protein models that scientists are creating. The Structural Genomics Consortium laboratory at Swedish medical university Karolinska Institutet has now made available the structure of PARP3, the four hundredth structure in this unique project to chart the body's proteins.

1 Apr 2007

New discoveries offer promise for cholesterol drugs

New discoveries offer promise for developing drugs that improve on the therapeutic profile of niacin, the inexpensive, time-tested B-vitamin that boosts levels of HDL cholesterol, the good cholesterol with the potential to protect people against heart attacks and stroke, scientists report.

1 Apr 2007

Penn State scientists reveal structure of gateways to gene control

Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome.

31 Mar 2007

Researchers identify gene for osteoporosis

Researchers report the identification of a gene that may play a role in susceptibility to osteoporosis, the crippling disease that leads to bone fractures, especially of the hip and spine.

31 Mar 2007

FDA approves Ceprotin to treat severe congenital protein C deficiency

The U.S. Food and Drug Administration (FDA) today licensed Ceprotin, the first biologic treatment for patients with a rare genetic defect that can cause a potentially life-threatening clotting disorder.

30 Mar 2007

Study shows how antibiotic gentamicin affects cystic fibrosis patients with a stop mutation

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest.

30 Mar 2007

Molecular mechanism involved in development of schizophrenia

In studying the postmortem brain tissue of adults who had been diagnosed with schizophrenia, the researchers found that levels of certain gene-regulating molecules called microRNAs were lower among schizophrenia patients than in persons who were free of psychiatric illness.

30 Mar 2007

Brain's immune system plays protective role in early Alzheimer's disease

The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder.

30 Mar 2007

Decoy receptor 3 expressed in rheumatic synovial fibroblasts protects the cells against Fas-induced apoptosis

A complex autoimmune disease, rheumatoid arthritis (RA) is characterized by chronic inflammation and progressive joint damage. This process begins with hyperplasia, or excessive increase in size and thickness, of synovial tissue. Along with provoking cartilage and bone destruction, this abnormal tissue growth is resistant to apoptosis, the natural cell death vital to the generation of healthy new cells.

30 Mar 2007