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Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy.

21 Mar 2017

Chemists develop biosafe luminescent nanoparticles for imaging tumors and blood vessels

Chemists from Russia and Switzerland created biosafe luminescent nanoparticles for imaging tumors and blood vessels damaged by heart attack or stroke.

21 Mar 2017

Genotype-guided warfarin dosing linked to reduced risk of adverse events

Using genetic testing to help personalize doses of warfarin therapy given to patients undergoing elective orthopedic surgery appears to lower the risk of combined adverse events compared with clinically guided dosing, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

21 Mar 2017

Study: Treatment window for Fragile X syndrome likely remains open into maturity after childhood

Brain samples from humans show that the treatment window for Fragile X syndrome likely remains open well into maturity after childhood, when previous tests with mice indicated it might close, according to a new Drexel University-led study.

21 Mar 2017

Research findings hold promise to generate blood cell precursors from hPSCs

The Galat laboratory at Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC).

21 Mar 2017

New study provides insights into strengths and vulnerabilities of couples raising child with ASD

Like all parents, couples who have a child with autism spectrum disorder (ASD) share the ups and downs of parenting.

21 Mar 2017

New gene-silencing drugs cut cholesterol levels by half in early research

The first in a new class of gene-silencing drugs, known as inclisiran, has been shown to halve cholesterol levels in patients at risk of cardiovascular disease.

21 Mar 2017

Salk scientists develop new way to find responders to lithium therapy

For roughly one-third of people diagnosed with bipolar disorder, lithium is a miracle drug, effectively treating both their mania and depression. But once someone is diagnosed, it can take up to a year to learn whether that person will be among the 30 percent who respond to lithium or the 70 percent who do not.

21 Mar 2017

Scientists to examine how stem cells proliferate faster in microgravity without side effects

Growing significant numbers of human stem cells in a short time could lead to new treatments for stroke and other diseases. Scientists are sending stem cells to the International Space Station to test whether these cells proliferate faster in microgravity without suffering any side effects.

21 Mar 2017

Scientists identify molecules that may be key to drug resistance in estrogen-driven breast cancers

Three-quarters of all breast cancer tumors are driven by the hormone estrogen. These tumors are frequently treated with drugs to suppress estrogen receptor activity, but unfortunately, at least half of patients do not respond to these treatments, leaving them with drug-resistant tumors and few options.

20 Mar 2017

Modern guidelines may miss some African-Americans eligible for statin therapy

African Americans experience a disproportionately high risk of cardiovascular disease, and statin treatment can be an important tool to lower the risk of plaque building up in the arteries.

20 Mar 2017

Early treatment with stem cells can safely help recovery in stroke patients, study shows

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it's safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report.

20 Mar 2017

Deep brain stimulation could be effective treatment option for patients with severe depressions

Treatment with deep brain stimulation can provide lasting relief to patients suffering from previously non-treatable, severe forms of depression several years into the therapy or even eliminate symptoms entirely.

20 Mar 2017

New markers linked to recurrence of erratic heartbeats in some patients after ablation therapy

Ablation procedures restore a regular heartbeat in patients who have a dangerous, abnormal heart rhythm called atrial fibrillation. But it doesn't always work. Now, a new study suggests that certain molecules are associated with the recurrence of erratic heartbeats in some patients after ablation therapy.

20 Mar 2017

Study finds low utilization rates of life-saving medications for high-risk PE patients

Pulmonary embolism (PE), a blood clot in the lungs which causes shortness of breath and chest pain, is the third leading cardiovascular cause of death in the United States with more than 100, 000 lives taken each year.

20 Mar 2017

Research: Surgical approaches may not offer added benefit to patients with tennis elbow

Surgical approaches to treating tennis elbow may not offer additional benefit to patients, as discussed in research presented at the American Orthopaedic Society for Sports Medicine's Specialty Day in San Diego.

20 Mar 2017

Uninterrupted use of new anticoagulant reduces major bleeding events during atrial fibrillation ablation

Uninterrupted treatment with dabigatran, a non-vitamin K antagonist oral anticoagulant (NOACs), before, during and after ablation to treat atrial fibrillation significantly reduced the incidence of major bleeding events compared with uninterrupted use of the more established anticoagulant warfarin, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Closing left atrial appendage linked to reduction in stroke risk for AFib patients

For patients with atrial fibrillation (AFib), a common heart rhythm disorder, closing the area of the heart known as the left atrial appendage as an add-on procedure during cardiac surgery was associated with a 40 percent reduction in the risk of thromboembolism (a condition when a blood clot forms and blocks an artery, which can cause a stroke or other complications) according to an observational study presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Study reveals link between endovascular procedures and microbleeding in the brain

Small leakages from blood vessels in the brain, known as microbleeds, increase with age and are associated with cognitive decline. Of 84 older patients undergoing transcatheter aortic valve replacement (TAVR), nearly a quarter developed new microbleeds after their procedure, according to results of a single-center study presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

CT scans reveal subclinical leaflet thrombosis in patients undergoing aortic valve replacement

About 12 percent of patients undergoing aortic valve replacement developed non-symptomatic blood clots around the valve leaflets (known as subclinical leaflet thrombosis) that reduced the motion of the valves, according to an observational study presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Therapy News and Research

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Chemists develop biosafe luminescent nanoparticles for imaging tumors and blood vessels

Genotype-guided warfarin dosing linked to reduced risk of adverse events

Study: Treatment window for Fragile X syndrome likely remains open into maturity after childhood

Research findings hold promise to generate blood cell precursors from hPSCs

New study provides insights into strengths and vulnerabilities of couples raising child with ASD

New gene-silencing drugs cut cholesterol levels by half in early research

Salk scientists develop new way to find responders to lithium therapy

Scientists to examine how stem cells proliferate faster in microgravity without side effects

Scientists identify molecules that may be key to drug resistance in estrogen-driven breast cancers

Modern guidelines may miss some African-Americans eligible for statin therapy

Early treatment with stem cells can safely help recovery in stroke patients, study shows

Deep brain stimulation could be effective treatment option for patients with severe depressions

New markers linked to recurrence of erratic heartbeats in some patients after ablation therapy

Study finds low utilization rates of life-saving medications for high-risk PE patients

Research: Surgical approaches may not offer added benefit to patients with tennis elbow

Uninterrupted use of new anticoagulant reduces major bleeding events during atrial fibrillation ablation

Closing left atrial appendage linked to reduction in stroke risk for AFib patients

Study reveals link between endovascular procedures and microbleeding in the brain

CT scans reveal subclinical leaflet thrombosis in patients undergoing aortic valve replacement

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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