Preclinical News and Research

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Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Researchers uncover new mechanism that plays key role in the progression of alcohol-related liver disease

Alcohol-related liver disease is among the most common causes of morbidity and mortality worldwide. Due to an incomplete understanding of the factors contributing to disease development, liver transplantation is still the only available cure.

24 Jan 2023

Mitochondrial dysfunction and endothelial impairment linked to many cardiovascular diseases

Many cardiovascular diseases, such as atherosclerosis, or 'hardening of the arteries,' correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels.

23 Jan 2023

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Aston University scientists are working with start-up company, Isterian Biotech, part of Cambrian BioPharma, to develop novel drugs to treat fibrotic diseases such as lung disease.

23 Jan 2023

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Immunotherapies have improved outcomes of many patients with cancer, including melanoma. But these therapies work for only a subset of patients.

23 Jan 2023

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

In a recent study published in The Lancet Microbe journal, researchers described the effectiveness of a modular capsid virus-like coronavirus disease 2019 (COVID-19) vaccination.

22 Jan 2023

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators.

19 Jan 2023

Wistar scientists receive $397,663 to explore the ability of natural killer cells to kill HIV-infected cells

amfAR, The Foundation for AIDS Research, has awarded Luis J. Montaner, D.V.M., D.Phil., in collaboration with Mohamed Abdel-Mohsen, Ph.D., a Target Grant for $397,663 over two years. Montaner, who leads The Wistar Institute's HIV Research Program, is studying the ability of a type of immune cell known as natural killer (NK) cells to kill HIV-infected cells.

19 Jan 2023

Experimental regenerative medicine shows potential to restore bone in an animal

Bone loss is a part of aging that compromises quality of life and movement in many older people, but regenerative treatments to improve their health and well-being have been limited.

19 Jan 2023

Study elucidates the potential role of STRO-001 in B-cell non-Hodgkin lymphoma

A new research paper was published in Oncotarget's Volume 14 on January 12, 2023, entitled, "Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001."

18 Jan 2023

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Mice exposed to World Trade Center dust exhibit a significant impairment in spatial recognition and short- and long-term memory, as well as changes in genes related to immune-inflammatory responses and blood-brain barrier disruption, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and published January 17 in the Journal of Alzheimer's Disease.

17 Jan 2023

Future COVID-19 control will require vaccines that induce better mucosal immunity

In a recent study posted to the medRxiv* preprint server, researchers in France explored the relationship between long-term immunoglobulin (Ig)-A response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and taste and smell disorders.

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system

Expansion of five-year collaboration broadens established Organ-on-a-chip research demonstrating advanced performance of the PhysioMimix MPS.

From CN Bio 17 Jan 2023

Researchers develop innovative STAb therapy for a type of leukemia

Researchers of the Hospital Universitario 12 de Octubre in Madrid and the Josep Carreras Leukaemia Research Institute have developed a cell therapy for a type of leukemia which currently has very few treatment options.

16 Jan 2023

Caterpillars could be used as an alternative to mammalian models to study gut inflammation

Rats and mice have been the backbone of biomedical research for decades - including research to understand cancer and pioneer new treatments.

12 Jan 2023

Silencing the immune evasion gene enhances cancer cells' susceptibility to immunotherapy

Immune checkpoint inhibitors are important medications that boost the immune system's response against various cancers, but some patients' cancer cells are unaffected by the drugs or develop resistance during treatment.

12 Jan 2023

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics that promote remyelination for the treatment of neurological diseases such as multiple sclerosis, announced today it has entered into an exclusive worldwide license agreement with UCB.

12 Jan 2023

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

CAR T cell therapy, an approach which reprograms patients' own immune cells to attack their blood cancers, may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

11 Jan 2023

Preclinical News and Research

Study reveals sex differences in response to drugs targeting tauopathies

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

Researchers uncover new mechanism that plays key role in the progression of alcohol-related liver disease

Mitochondrial dysfunction and endothelial impairment linked to many cardiovascular diseases

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

Wistar scientists receive $397,663 to explore the ability of natural killer cells to kill HIV-infected cells

Experimental regenerative medicine shows potential to restore bone in an animal

Study elucidates the potential role of STRO-001 in B-cell non-Hodgkin lymphoma

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Future COVID-19 control will require vaccines that induce better mucosal immunity

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

The FDA further expands collaboration with CN Bio to evaluate the PhysioMimix Multi-organ microphysiological system

Researchers develop innovative STAb therapy for a type of leukemia

Caterpillars could be used as an alternative to mammalian models to study gut inflammation

Silencing the immune evasion gene enhances cancer cells' susceptibility to immunotherapy

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

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