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Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver.

9 Jan 2017

UI scientists reveal how high-dose vitamin C damages cancer cells

Vitamin C has a patchy history as a cancer therapy, but researchers at the University of Iowa believe that is because it has often been used in a way that guarantees failure.

9 Jan 2017

Research findings may provide new treatment for prevention of cancer metastasis

Breast cancer metastasis, the process by which cancer spreads, may be prevented through the new use of a class of drugs already approved by the U.S. Food and Drug Administration.

9 Jan 2017

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment

Hubrecht Organoid Technology (HUB), and the health insurance companies CZ, Zilveren Kruis, and Menzis announced today that they will start a €3 million validation trial for use of HUB Organoid Technology to test if it can be used to determine the response of Cystic Fibrosis (CF) patients to new drug therapies.

9 Jan 2017

Study suggests use of tablet devices as safe, effective way to control agitation among dementia patients

A new pilot study led by McLean Hospital's Ipsit Vahia, MD, medical director of Geriatric Psychiatry Outpatient Services at McLean Hospital, suggests that the use of tablet computers is both a safe and a potentially effective approach to managing agitation among patients with dementia.

9 Jan 2017

Northwestern Medicine scientists identify targeted molecular therapy that halts childhood leukemia

Northwestern Medicine scientists have discovered the genetic driver of a rare and lethal childhood leukemia and identified a targeted molecular therapy that halts the proliferation of leukemic cells.

6 Jan 2017

Yale study highlights treatment burden experienced by older lung cancer patients

Depending on the type of treatment older lung cancer patients receive, they can spend an average of one in three days interacting with the healthcare system in the first 60 days after surgery or radiation therapy, according to a study by Yale researchers.

6 Jan 2017

Georgia Tech researchers find new way to improve treatment for inflammatory diseases

Is a treatment only making things better or maybe also making some things a little worse? That can be a nagging question in some medical decisions, where side effects are possible.

6 Jan 2017

Study shows promising results for treating lymphoma patients with immune cell therapy

Lymphoma is the most common blood cancer. The disease occurs when immune cells called lymphocytes multiply uncontrollably. Cancerous lymphocytes can travel throughout the body and form lymph node tumors.

6 Jan 2017

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.

6 Jan 2017

FDA-approved, bioengineered living-cell therapy can shift genomic profile of non-healing wounds

Apligraf - an FDA-approved, bioengineered living-cell therapy from Organogenesis Inc. - has become the first wound-healing therapy to demonstrate a significant change in the genomic profile of a treated non-healing wound, according to new research published in the peer-reviewed journal Science Translational Medicine.

6 Jan 2017

Researchers develop novel tests that could improve treatment for heart failure patients

For the first time, researchers have developed tests that could improve treatment for heart failure patients by diagnosing the condition with greater accuracy, as well as by detecting the onset of congestive heart failure earlier.

5 Jan 2017

Study identifies factors linked to disengagement from treatment for opioid use disorder

Individuals with opioid use disorder who are treated with buprenorphine, a commonly prescribed drug to treat addiction, are more likely to disengage from treatment programs if they are black or Hispanic, unemployed, or have hepatitis C according to a study published online in the Journal of Substance Abuse Treatment.

5 Jan 2017

Concussed children with vision abnormalities have academic difficulty, research shows

A comprehensive vision assessment should be part of return-to-learn protocols to help determine when children are ready to return to the classroom following concussions -- particularly in children reporting academic difficulty.

5 Jan 2017

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Treatment with an inhibitor of 12/15-lipoxygenase, an enzyme elevated in patients with Alzheimer's disease (AD), reverses cognitive decline and neuropathology in an AD mouse model, reports a new study in Biological Psychiatry.

5 Jan 2017

Genetic influence on immune system appears to be higher than previously thought

Nearly three quarters of immune traits are influenced by genes, new research from King's College London reveals.

5 Jan 2017

ESCMID grant helps young investigators to study microorganisms, find better approaches to treat infectious diseases

The European Society of Clinical Microbiology and Infectious Diseases through its annual grant programme helps young investigators pursue ground-breaking research to advance our understanding of microorganisms and find better approaches to diagnose, prevent and treat infectious diseases.

5 Jan 2017

Study links acid suppression therapy to increased risk of intestinal infections

In a population-based study from Scotland, use of commonly-prescribed acid suppression medications such as proton pump inhibitors (PPIs) was linked with an increased risk of intestinal infections with C. difficile and Campylobacter bacteria, which can cause considerable illness.

5 Jan 2017

Yoga during active treatment can provide QOL benefits for pediatric cancer patients and parents

A yoga program for children with cancer can be carried out even during cancer treatment, and has quality of life (QOL) benefits for the children as well as their parents, suggests a study in Rehabilitation Oncology, official journal of the Oncology Section of the American Physical Therapy Association.

5 Jan 2017

Afib patients more likely to discontinue anticoagulant therapy after procedure, research finds

For patients with atrial fibrillation, the most common form of heart arrhythmia, a main goal of treatment is stroke prevention.

5 Jan 2017

Therapy News and Research

Epigenetic changes favor development of fatty liver in humans and mice

UI scientists reveal how high-dose vitamin C damages cancer cells

Research findings may provide new treatment for prevention of cancer metastasis

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment

Study suggests use of tablet devices as safe, effective way to control agitation among dementia patients

Northwestern Medicine scientists identify targeted molecular therapy that halts childhood leukemia

Yale study highlights treatment burden experienced by older lung cancer patients

Georgia Tech researchers find new way to improve treatment for inflammatory diseases

Study shows promising results for treating lymphoma patients with immune cell therapy

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

FDA-approved, bioengineered living-cell therapy can shift genomic profile of non-healing wounds

Researchers develop novel tests that could improve treatment for heart failure patients

Study identifies factors linked to disengagement from treatment for opioid use disorder

Concussed children with vision abnormalities have academic difficulty, research shows

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Genetic influence on immune system appears to be higher than previously thought

ESCMID grant helps young investigators to study microorganisms, find better approaches to treat infectious diseases

Study links acid suppression therapy to increased risk of intestinal infections

Yoga during active treatment can provide QOL benefits for pediatric cancer patients and parents

Afib patients more likely to discontinue anticoagulant therapy after procedure, research finds

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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