Preclinical News and Research

RSS

RNAs may be a promising biomarker and therapeutic target for ischemic stroke

RUDN doctors analyzed the latest research on the use of RNA for the treatment and diagnosis of ischemic stroke.

10 Jan 2023

What are the effects of prenatal exposure to alcohol and marijuana on fetal development?

Researchers presented the effects of simultaneous alcohol and cannabinoid (SAC) usage during gestation on fetal brain development.

10 Jan 2023

Researchers develop a novel, improved system for identifying fluorescent agents

The nascent field of fluorescence-guided surgery (FGS) is fast growing, with potential to vastly improve the safety and efficacy of surgical procedures.

9 Jan 2023

Does the immunization order of vaccine types influence the efficacy of heterologous prime-boost vaccination, especially mRNA and protein-based vaccines?

A new study aimed to analyze whether the order of immunization of vaccine types impacted the efficacy of a heterologous prime-boost vaccination strategy.

6 Jan 2023

Insilico Medicine launches a 6th generation Intelligent Robotics Drug Discovery Laboratory

Insilico Medicine, a clinical stage, end-to-end artificial intelligence (AI)-driven drug discovery company, held the launch ceremony for Life Star – a 6th generation Intelligent Robotics Drug Discovery Laboratory – in Suzhou BioBAY Industrial Park on Dec. 29.

5 Jan 2023

Oxford's Ebola vaccine candidate manufactured and shipped to Uganda in just 80 days

Oxford's Ebola vaccine candidate has been shipped to Uganda, just 80 days after WHO declared a Sudan ebolavirus outbreak, having been manufactured by its partner the Serum Institute of India and working in close partnership with WHO.

5 Jan 2023

Researchers discover novel candidate drug targets for advanced non-alcoholic fatty liver disease

Using the latest technologies - including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells - researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease (NAFLD).

4 Jan 2023

The interrelationship between diet, physical health, and depression

A recent Journal of Affective Disorders study examined the interrelationship between diet, physical health, and depression.

4 Jan 2023

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation.

3 Jan 2023

Novel triple immunotherapy combination improves anti-tumor responses in preclinical models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis and limited treatment options.

3 Jan 2023

Phase III trial shows noninferiority of VV116 compared to nirmatrelvir–ritonavir among adults with mild-to-moderate COVID-19 at risk of progression

Researchers presented the results of a phase III randomized controlled trial of oral SARS-CoV-2 antiviral VV116.

3 Jan 2023

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Insilico Medicine ("Insilico"), a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that the company's drug discovery team has nominated a preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy utilizing its end-to-end Pharma.AI platform.

27 Dec 2022

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

Lung cancer is the deadliest cancer in the United States and around the world. Many of the currently available therapies have been ineffective, leaving patients with very few options.

26 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Pancreatic cancer is one of the deadliest types of cancer - in the U.S., it is estimated that over 88 percent of people will die from the disease within five years of their diagnosis.

20 Dec 2022

Study highlights the importance of the gut microbiota during early neurodevelopment

A recent Brain, Behavior, and Immunity study investigated the role of the early-life gut microbiota in determining neurodevelopmental outcomes.

19 Dec 2022

Low ET levels in blood plasma may predict increased risk of cognitive impairment, dementia

A recent study by a team comprising researchers from the National University of Singapore and the National University Health System revealed that low levels of ergothioneine in blood plasma may predict an increased risk of cognitive impairment and dementia, suggesting possible therapeutic or early screening measures for cognitive impairment and dementia in the elderly.

19 Dec 2022

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models, according to a new study by Weill Cornell Medicine investigators.

16 Dec 2022

Vaping may negatively affect pulmonary surfactant in the lungs, study shows

A recently published preclinical study by researchers at Lawson Health Research Institute and Western University's Schulich School of Medicine & Dentistry, show that vaping may negatively affect pulmonary surfactant in the lungs.

14 Dec 2022

Preclinical News and Research

RNAs may be a promising biomarker and therapeutic target for ischemic stroke

What are the effects of prenatal exposure to alcohol and marijuana on fetal development?

Researchers develop a novel, improved system for identifying fluorescent agents

Does the immunization order of vaccine types influence the efficacy of heterologous prime-boost vaccination, especially mRNA and protein-based vaccines?

Insilico Medicine launches a 6th generation Intelligent Robotics Drug Discovery Laboratory

Oxford's Ebola vaccine candidate manufactured and shipped to Uganda in just 80 days

Researchers discover novel candidate drug targets for advanced non-alcoholic fatty liver disease

The interrelationship between diet, physical health, and depression

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Novel triple immunotherapy combination improves anti-tumor responses in preclinical models of pancreatic cancer

Phase III trial shows noninferiority of VV116 compared to nirmatrelvir–ritonavir among adults with mild-to-moderate COVID-19 at risk of progression

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Study highlights the importance of the gut microbiota during early neurodevelopment

Low ET levels in blood plasma may predict increased risk of cognitive impairment, dementia

Experimental therapy shows promise as treatment for metastatic colon cancer in preclinical models

Vaping may negatively affect pulmonary surfactant in the lungs, study shows

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics