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Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

17 Oct 2018

Expanding the knowledge about hippocampus to better understand cognitive deficits in MS

A recent article by a team of international experts on multiple sclerosis (MS) underscores the importance of expanding the knowledge base about the hippocampus in order to better understand the genesis of cognitive deficits and develop new treatment strategies.

17 Oct 2018

Environmental conditions may drive development of multiple sclerosis

A new Tel Aviv University study finds that certain environmental conditions may precipitate structural changes that take place in myelin sheaths in the onset of multiple sclerosis. Myelin sheaths are the "insulating tape" surrounding axons; axons carry electrical impulses in neurons.

16 Oct 2018

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier--which keeps large molecules in the blood from entering the brain--becomes abnormally permeable, allowing fibrin to leak into the brain and trigger inflammation.

16 Oct 2018

New patient-centric website launched in Europe to empower people with chronic conditions

Teva Pharmaceutical Industries Ltd. today announced the European launch of Life Effects (https://lifeeffects.teva), a patient-centric website hosting content created by patients and checked by experts, at the European Committee for the Treatment and Research of Multiple Sclerosis Congress in Berlin.

12 Oct 2018

Gut microbiota could play greater role in pathogenesis of MS than previously thought

In multiple sclerosis, a defective response of the body’s own immune system leads to brain tissue damage. Gastrointestinal microbiota could play a far greater role in the pathogenesis of the disease than previously assumed, researchers at the University of Zurich have now found.

11 Oct 2018

Teva announces European launch of patient-centric website

Teva Pharmaceutical Industries Ltd. today announced the European launch of Life Effects, a patient-centric website hosting content created by patients and checked by experts, at the European Committee for the Treatment and Research of Multiple Sclerosis Congress in Berlin.

11 Oct 2018

Will Maine voters decide to make aging in place affordable?

As Election Day draws near, a ballot initiative in Maine to provide universal home care is shining a spotlight on the inadequacies of the nation's long-term care system.

11 Oct 2018

UK Biobank provides wealth of information for further genetic studies

There are 3.2 billion positions on the human genome and it requires a study of huge number of genetic variations in the populations to estimate the associations between genetic disorders and mutations. Two new studies have been published in the journal Nature.

11 Oct 2018

Drug treatment at a young age could help reverse autism-like behavior in tuberous sclerosis

New research on autism has found, in a mouse model, that drug treatment at a young age can reverse social impairments. But the same intervention was not effective at an older age.

10 Oct 2018

Brown researchers uncover new clues about ALS progression

Brown University researchers have uncovered new clues about the progression of Amyotrophic Lateral Sclerosis (ALS), a surprisingly common disease that causes the death of motor neurons that control voluntary muscles such as those involved in walking, talking, chewing or breathing.

10 Oct 2018

Study highlights sex differences in 'thermal behavior'

New research from the University at Buffalo has, for the first time, identified differences between men and women in their preferences for maintaining comfort both while exercising and in recovery. The results could one day inform the development of new athletic apparel.

10 Oct 2018

New project aims to improve long-term patient monitoring through remote assessment

Under conventional medical practice, monitoring long-term patients is done in the clinic or hospital, assessing such things as treatment effects, adverse events and disease course.

9 Oct 2018

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Novartis today announced that both the US Food and Drug Administration and European Medicines Agency have accepted the company's New Drug Application and Marketing Authorization Application respectively, for investigational oral, once-daily siponimod (BAF312) for the treatment of secondary progressive multiple sclerosis in adults.

8 Oct 2018

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Genentech, a member of the Roche Group, announced today interim clinical data from the dose-finding parts of the pivotal FIREFISH and SUNFISH studies investigating risdiplam in spinal muscular atrophy.

3 Oct 2018

Researchers find ALS drug as potential treatment for prostate cancer

Researchers have discovered a new use for an old drug as a potential treatment for prostate cancer. The findings are published in the journal The Prostate.

3 Oct 2018

Researchers discover how nerve cells control movement

Researchers at Karolinska Institutet in Sweden have discovered a new way in which nerve cells can control movement. In a study on zebrafish published in the journal PNAS they show that the contact between neurons and muscles is more dynamic than previously thought.

3 Oct 2018

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).

3 Oct 2018

New, more efficient method for generating brain stem cells in the lab

In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory.

1 Oct 2018

Axol's Human iPSC-derived Microglia for neuroimmunology research

Our Human iPSC-derived Microglia are suitable for a variety of applications including in vitro disease models, phenotypic screening and immunology studies.

From Axol Bioscience Ltd 27 Sep 2018

Sclerosis News and Research

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Expanding the knowledge about hippocampus to better understand cognitive deficits in MS

Environmental conditions may drive development of multiple sclerosis

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

New patient-centric website launched in Europe to empower people with chronic conditions

Gut microbiota could play greater role in pathogenesis of MS than previously thought

Teva announces European launch of patient-centric website

Will Maine voters decide to make aging in place affordable?

UK Biobank provides wealth of information for further genetic studies

Drug treatment at a young age could help reverse autism-like behavior in tuberous sclerosis

Brown researchers uncover new clues about ALS progression

Study highlights sex differences in 'thermal behavior'

New project aims to improve long-term patient monitoring through remote assessment

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Researchers find ALS drug as potential treatment for prostate cancer

Researchers discover how nerve cells control movement

Alnylam reports further progress on broadening the therapeutic potential of RNAi

New, more efficient method for generating brain stem cells in the lab

Axol's Human iPSC-derived Microglia for neuroimmunology research

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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