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SUMO1 gene implicated in cleft lip and palate defects

Researchers supported by the National Institutes of Health report in the current issue of the journal Science that a much-studied gene called SUMO1, when under expressed, can cause cleft lip and palate, one of the world's most common birth defects.

21 Sep 2006

New understanding of how cells defend themselves

Biologists at the EPFL (Ecole Polytechnique Federale de Lausanne) have unveiled a new twist in a metabolic pathway that cells use to defend themselves against toxins made by disease-causing bacteria.

21 Sep 2006

Calcineurin/Nfat signaling is required for perinatal lung maturation and function

It is only very late in pregnancy that the lungs of the fetus complete their development so that the fetus will be able to breathe air when it is born.

21 Sep 2006

Direct observations of DNA provides new insights into how genetic material is copied and repaired

"We can monitor the process directly, and that gives us a different perspective," said Roberto Galletto, a postdoctoral scholar at UC Davis and first author on a paper published Sept. 20 on the Web site of the journal Nature.

21 Sep 2006

New target for cancer therapy identified by Australian researchers

A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development.

21 Sep 2006

Nitric oxide helps pregnant women with hypertension

Nitric oxide (NO) is best known as an air pollutant produced by vehicle emissions and power plants but for pregnant women it is a crucial compound required to avoid hypertension and pre-eclampsia.

21 Sep 2006

Drugs that enhance the activity of calcineurin or NFAT could become a new treatment for type-2

Certain immune-suppressing drugs, such as those taken by patients who have had organ transplants, greatly increase the risk of developing diabetes. These drugs are known to put a stranglehold on a protein called calcineurin.

21 Sep 2006

Leptin could combat type 2 diabetes

University of Florida researchers have discovered the appetite-controlling hormone leptin could also combat type 2 diabetes, a disease that has become a growing problem in the United States as more Americans pack on extra pounds.

21 Sep 2006

Cabernet Sauvignon may reduce incidence of Alzheimer's Disease

A new study directed by Mount Sinai School of Medicine has found that moderate red wine consumption in a form of Cabernet Sauvignon may help reduce the incidence of Alzheimer's Disease (AD).

20 Sep 2006

Fetal survival following preeclamptic pregnancy has improved

...substantially over the last 35 years in Norway, likely due to a reduction in stillbirths and improvements in clinical management, according to a study in the September 20 issue of JAMA: The Journal of the American Medical Association.

20 Sep 2006

p120 catenin protein can stop metastasis or promote it

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.

20 Sep 2006

Fat droplets play protective role inside cells

Too much body fat may be a bad thing, but there is increasing evidence that too little fat also may have some surprisingly negative consequences.

19 Sep 2006

Curcumin useful in the fight against colorectal cancer

Looking for a cancer cure? Try the spice rack. In the last few years, that tactic has proved productive for researchers investigating turmeric, a curry spice used for centuries in Indian traditional medicine.

19 Sep 2006

Detecting cancer with silica nanoparticles

Tumor necrosis factor-alpha is a widely accepted biomarker for cancer, but the minute amounts of this protein circulating in blood makes detecting the molecule and measuring its concentration accurately a technological challenge.

19 Sep 2006

Researchers create roadmap to integrin activation

Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critical to the control of bleeding and to the thrombosis that occurs in heart attacks and strokes.

18 Sep 2006

New evidence in Libyan medic trial appears shaky

At the retrial in Tripoli of six medics accused of infecting 400 children with HIV, a Libyan court has been hearing evidence from four new prosecution witnesses.

13 Sep 2006

Study extends the number of antigenic peptides that can be produced from a single protein

Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein. In fact, colinearity of DNA and protein sequences is thought to be a fundamental feature of the universal genetic code.

13 Sep 2006