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Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20–30% patients with cancer respond to ICI treatment.

29 Mar 2023

Study shows benefits of expanding the use of telehealth services for people with opioid use disorder

The expanded availability of opioid use disorder-related telehealth services and medications during the COVID-19 pandemic was associated with a lowered likelihood of fatal drug overdose among Medicare beneficiaries, according to a new study.

29 Mar 2023

Experimental anti-obesity drug may control appetite without surgery or nausea

Imagine getting the benefits of gastric bypass surgery without going under the knife - a new class of compounds could do just that. In lab animals, these potential treatments reduce weight dramatically and lower blood glucose.

29 Mar 2023

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

A National Institutes of Health team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

29 Mar 2023

Low vaccine coverage fuels recurrence of diphtheria in Nigeria

Low vaccine coverage and weak infrastructure have fuelled a recurrence of diphtheria in Nigeria, especially in rural areas beset by poor access to healthcare services, public health experts say.

28 Mar 2023

Clinical trial of ENZAMET shows promising results for men with advanced prostate cancer

A new drug combination for men with advanced prostate cancer has shown sustained increase in survival rates.

28 Mar 2023

NIH scientists discover an autoinflammatory disease caused by mutations in the LYN gene

Scientists have identified an autoinflammatory disease caused by mutations in the LYN gene, an important regulator of immune responses in health and disease.

28 Mar 2023

IU Cancer Center secures new, renewed ACS funding to support research and education programs

As part of a longstanding partnership, the Indiana University Melvin and Bren Simon Comprehensive Cancer Center has received new and renewed funding from the American Cancer Society to support research and education programs.

27 Mar 2023

Myeloid cells can harbor HIV in people taking antiretroviral therapy

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

27 Mar 2023

Computational approach used to understand the mechanisms of protein folding in tauopathies

A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases.

27 Mar 2023

Breast tumors of women from different racial groups have diverse cellular, microbial and genomic features

The breast tumors of Asian, Black and white women have very different cellular, microbial and genomic features that could potentially be used to personalize care or predict disease progression, according to new research by investigators at the Johns Hopkins Kimmel Cancer Center.

27 Mar 2023

Targeting the STING pathway with a combination strategy promotes antitumor activity

Immunotherapies have greatly improved the outcomes of many patients with melanoma. But there is still a need for new approaches for the subset of patients who do not respond well to this type of therapy.

27 Mar 2023

Discontinuing use of THC may reverse its effects on male fertility

A 2022 study from Oregon Health & Science University researchers confirmed that chronic use of cannabis may greatly impact male fertility and reproductive outcomes in nonhuman primates - but it was unclear whether the effects are permanent.

27 Mar 2023

Smart bandage may make treatment of chronic wounds easier, more effective

Most of the time, when someone gets a cut, scrape, burn, or other wound, the body takes care of itself and heals on its own.

24 Mar 2023

Hidden "super spreader" spaces associated with a predominance of asymptomatic cases of dengue

For mosquito-borne diseases such as dengue fever, the abundance of the insects in places where people gather has long served as the main barometer for infection risk.

23 Mar 2023

£1.3 million awarded to develop a new "point of care testing" kit for detecting Alzheimer's biomarkers

Scientists from Swansea University 's Institute for Innovative Materials, Processing and Numerical Technologies (IMPACT) and Japan have been awarded £1.3 million to develop a new "point of care testing" kit that can detect biomarkers for Alzheimer's Disease.

23 Mar 2023

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Researchers at the Francis Crick Institute have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB.

23 Mar 2023

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

In a recent study published in the journal BMJ Medicine, researchers in the United Kingdom and Sweden investigated the probable causality of long-term serum caffeine concentrations on type 2 diabetes (T2D), adiposity, and major cardiovascular diseases (CVDs).

22 Mar 2023

Study finds shared genetic risk variants across different substance use disorders

By combing through genomic data of over 1 million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used.

22 Mar 2023

Researchers identify the cellular glitches underlying a rare genetic disorder

The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations that disrupt immune cell signaling through a protein called PI3K.

21 Mar 2023

Medical Research News and Research

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Study shows benefits of expanding the use of telehealth services for people with opioid use disorder

Experimental anti-obesity drug may control appetite without surgery or nausea

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

Low vaccine coverage fuels recurrence of diphtheria in Nigeria

Clinical trial of ENZAMET shows promising results for men with advanced prostate cancer

NIH scientists discover an autoinflammatory disease caused by mutations in the LYN gene

IU Cancer Center secures new, renewed ACS funding to support research and education programs

Myeloid cells can harbor HIV in people taking antiretroviral therapy

Computational approach used to understand the mechanisms of protein folding in tauopathies

Breast tumors of women from different racial groups have diverse cellular, microbial and genomic features

Targeting the STING pathway with a combination strategy promotes antitumor activity

Discontinuing use of THC may reverse its effects on male fertility

Smart bandage may make treatment of chronic wounds easier, more effective

Hidden "super spreader" spaces associated with a predominance of asymptomatic cases of dengue

£1.3 million awarded to develop a new "point of care testing" kit for detecting Alzheimer's biomarkers

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

Study finds shared genetic risk variants across different substance use disorders

Researchers identify the cellular glitches underlying a rare genetic disorder

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