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Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Researchers deploy mutagenesis studies to investigate the relationship between ORF6 localization and IFN antagonism.

12 Dec 2021

New tool to help map immune escape with SARS-CoV-2 mutations

A new study discusses a computational program that can be used to substitute for actual experimental evidence of the biologic impact of new mutations.

12 Dec 2021

First locally acquired infection of Omicron variant confirmed in San Diego

Officials at the San Diego County Health and Human Services Agency, working in collaboration with scientists at University of California San Diego and Scripps Research, have announced the second confirmed case — and first locally acquired infection — of the Omicron variant of SARS-CoV-2, the virus that causes COVID-19.

12 Dec 2021

Researchers discover new mechanism behind the formation of membrane vesicles

Canadian and American researchers have discovered a new mechanism by which membrane vesicles are made. These self-contained nanoparticles trap proteins, RNA and other molecules from inside or outside of living cells as nutrients or regulate the numbers of cell surface hormone receptors, such as those for insulin, to control the sensitivity of cells to hormones.

10 Dec 2021

Study finds mutational changes in Omicron variant likely increase transmissibility

A new study presented evidence for a large number of mutational changes in the Omicron variant which will likely increase its transmissibility and significantly decrease the neutralization capacity of monoclonal antibodies, leading to a decline in vaccine efficacy.

10 Dec 2021

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Researchers discovered that the entry of coronaviruses is a Ca2+-dependent process and focused their studies on the SARS-1 FP-Ca2+ interaction and its effect on membranes using electron spin resonance (ESR).

10 Dec 2021

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

A University of Florida Health researcher has successfully analyzed the many mutations in the omicron variant of the SARS-CoV-2 virus, a crucial step in better understanding the variant's potential threat and ways to combat it.

9 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

A team of researchers set out to build a full-length, membrane-embedded spike to study its conformational dynamics at the atomic level using molecular dynamics simulations to understand better how this important component of the virus machinery works.

8 Dec 2021

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

A recent review looks at the molecular design of pH-sensitive cationic lipids and their applications for various tissues and cell types.

7 Dec 2021

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Researchers investigate the conformational dynamics of the SARS-CoV-2 RBD using the atomistic molecular dynamics simulation method.

7 Dec 2021

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

The current study not only analyses the mutations in the Omicron spike variant but classifies various combinations of spike mutations into groups.

7 Dec 2021

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

A new study indicates an immunological response to SARS-CoV-2 vaccines in immunosuppressed patients that were comparable to healthy patients.

7 Dec 2021

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

A new study provides understanding of the intricate roles and functions of the different elements of spike proteins and shows how the spike protein samples a crowded surface of its host cell via the glycans.

7 Dec 2021

SARS-CoV-2 S2 immunization as a pan-coronavirus vaccine approach

A new mouse model suggests that prior HCoV-OC43 S immunity primes neutralising antibody responses to otherwise subimmunogenic SARS-CoV-2 S exposure as well as promotes S2-targeting antibody responses.

6 Dec 2021

Scientists find infection of sustentacular cells in the olfactory epithelium of COVID-19 patients

It is now widely known that COVID-19 is associated with the transient or long-term loss of olfaction (the sense of smell) but the mechanisms remain obscure.

6 Dec 2021

A faster, safer and more affordable technology to produce personalized cancer therapies

Cell therapy has become an indispensable part of medicine today. With this form of immunotherapy you use your own body cells as medicine to fight the disease.

6 Dec 2021

SARS-CoV-2 virus-like particles elicit potent neutralizing antibody response in variant challenge

Researchers develop a virus-like particle for SARS-CoV-2 based on the co-expression of the spike, membrane, and envelope structural proteins.

6 Dec 2021

Unvaccinated mothers encourage pregnant women to take up COVID-19 vaccine

Unvaccinated women who suffered with COVID-19 during their pregnancies have told their harrowing stories of battling the virus, from being hospitalized to having emergency c-sections, as part of a new campaign encouraging expectant mothers to get the vaccine.

5 Dec 2021

SARS-CoV-2 ORF10 degrades mitochondrial antiviral signaling protein to suppress immune response

A novel mechanism by which SARS-CoV-2 inhibits the innate immune response; that is, ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX.

5 Dec 2021

Membrane News and Research

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

New tool to help map immune escape with SARS-CoV-2 mutations

First locally acquired infection of Omicron variant confirmed in San Diego

Researchers discover new mechanism behind the formation of membrane vesicles

Study finds mutational changes in Omicron variant likely increase transmissibility

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

SARS-CoV-2 S2 immunization as a pan-coronavirus vaccine approach

Scientists find infection of sustentacular cells in the olfactory epithelium of COVID-19 patients

A faster, safer and more affordable technology to produce personalized cancer therapies

SARS-CoV-2 virus-like particles elicit potent neutralizing antibody response in variant challenge

Unvaccinated mothers encourage pregnant women to take up COVID-19 vaccine

SARS-CoV-2 ORF10 degrades mitochondrial antiviral signaling protein to suppress immune response

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