Neurodegenerative Diseases News and Research

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TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

Toll-like receptor 4 (TLR4) antibody, protein kinase B (AKT) inhibitor, LY 294002, and glycogen synthase kinase 3β (GSK-3β) inhibitor, LiCl, were used by Yu He and colleagues from Nantong University, China to attenuate or augment the effects of the TLR4-phosphatidylinositol 3 kinase (PI3K)/AKT-GSK-3β signaling pathway so as to identify the participation of this signaling system in the apoptosis of hippocampal neurons.

5 Dec 2013

Researchers take important step towards development of future drugs for brain diseases

A successful joint collaboration between researchers at the Hebrew university of Jerusalem and the startup company TyrNovo may lead to a potential treatment of brain diseases. The researchers found that TyrNovo's novel and unique compound, named NT219, selectively inhibits the process of aging in order to protect the brain from neurodegenerative diseases, without affecting lifespan. This is a first and important step towards the development of future drugs for the treatment of various neurodegenerative maladies.

4 Dec 2013

World-class Krembil Discovery Tower now opens in Canada

The Honourable Dr. K. Kellie Leitch, Minister of Labour and Minister of Status of Women congratulated Toronto Western Hospital today on the opening of the Krembil Discovery Tower, a facility dedicated to research excellence, training the next generation of medical professionals and improving health care for patients across Canada.

2 Dec 2013

Male roundworms shorten the lifespan of females, say Stanford researchers

Researchers at the Stanford University School of Medicine have discovered that males of the laboratory roundworm secrete signaling molecules that significantly shorten the lifespan of the opposite sex.

29 Nov 2013

Mutation in alpha-synuclein gene causes increased vulnerability to pesticides, leading to Parkinson's

A team of researchers has brought new clarity to the picture of how gene-environmental interactions can kill nerve cells that make dopamine. Dopamine is the neurotransmitter that sends messages to the part of the brain that controls movement and coordination.

27 Nov 2013

Protecting or boosting neurotrophins may slow progression of Huntington's disease

A drug that acts like a growth-promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience. The findings add to a growing body of evidence that protecting or boosting neurotrophins - the molecules that support the survival and function of nerve cells - may slow the progression of Huntington's disease and other neurodegenerative disorders.

27 Nov 2013

Inhibitor compounds could form basis of new treatments for such diseases as MRSA, anthrax

Inhibitor compounds developed by UC Irvine structural biologists and Northwestern University chemists have been shown to bolster the ability of antibiotics to treat deadly bacterial diseases such as MRSA and anthrax.

27 Nov 2013

£20M research centre opened to investigate exciting new therapies for neurodegenerative diseases

A specialist £20 million research centre, funded by the Wolfson Foundation and dedicated to carrying out first-in-human studies, opens in London today (15th November). Researchers at the Leonard Wolfson Experimental Neurology Centre (LWENC) will investigate exciting new therapies for neurodegenerative diseases such as Alzheimer's and Parkinson's.

16 Nov 2013

Professor from LSUHSC receives Professor Miroslaw Medal from Polish Academy of Sciences

Nicolas G. Bazan, MD, PhD, Boyd Professor and Director of the LSU Health Sciences Center New Orleans Neuroscience Center of Excellence, has been awarded the Professor Miroslaw M. Mossakowski Medal by the Polish Academy of Sciences.

11 Nov 2013

Researchers identify critical mechanism to improve survival and behavior of new brain cells

A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report.

11 Nov 2013

Researchers identify novel therapeutic approach for most frequent genetic cause of ALS

A team of scientists led by researchers from the University of California, San Diego School of Medicine and Ludwig Institute for Cancer Research have identified a novel therapeutic approach for the most frequent genetic cause of ALS, a disorder of the regions of the brain and spinal cord that control voluntary muscle movement, and frontal temporal degeneration, the second most frequent dementia.

10 Nov 2013

Research findings may lead to new treatments, approaches for controlling multiple sclerosis

Scientists are gaining a new level of understanding of multiple sclerosis that may lead to new treatments and approaches to controlling the chronic disease, according to new research released today at Neuroscience 2013, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

10 Nov 2013

Oligomeric proanthocyanidin has protective effect on retinal ganglion cells, shows study

The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death.

4 Nov 2013

Scientists identify new toxic entity associated with dementia and motor neuron disease

A new toxic entity associated with genetically inherited forms of dementia and motor neuron disease has been identified by scientists at the UCL Institute of Neurology. The toxin is the result of a genetic mutation that leads to the production of RNA molecules which could be responsible for the diseases. The findings are published in the journal Acta Neuropathologica.

31 Oct 2013

Cellectricon to demonstrate Cellaxess technology at Neuroscience 2013

Cellectricon, a leading provider of advanced cell-based screening technologies and services, will be presenting new data at Neuroscience 2013, 9-13 November, San Diego (USA).

From Cellectricon 31 Oct 2013

NIH selects two leading researchers to chair panels at geroscience symposium

The National Institutes of Health (NIH) has chosen two leading aging researchers at Albert Einstein College of Medicine of Yeshiva University to chair panels at the first symposium on "geroscience"-the study of how aging influences the onset of chronic diseases.

30 Oct 2013

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

30 Oct 2013

Video gaming increases spatial orientation, memory formation and motor skills

Video gaming causes increases in the brain regions responsible for spatial orientation, memory formation and strategic planning as well as fine motor skills.

30 Oct 2013

Rutgers scientists provide new information about rare genetic childhood disorder

Scientists at Rutgers University studying the cause of a rare childhood disease that leaves children unable to walk by adolescence say new findings may provide clues to understanding more common neurodegenerative diseases like Alzheimer's and Parkinson's and developing better tools to treat them.

28 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

Neurodegenerative Diseases News and Research

TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

Researchers take important step towards development of future drugs for brain diseases

World-class Krembil Discovery Tower now opens in Canada

Male roundworms shorten the lifespan of females, say Stanford researchers

Mutation in alpha-synuclein gene causes increased vulnerability to pesticides, leading to Parkinson's

Protecting or boosting neurotrophins may slow progression of Huntington's disease

Inhibitor compounds could form basis of new treatments for such diseases as MRSA, anthrax

£20M research centre opened to investigate exciting new therapies for neurodegenerative diseases

Professor from LSUHSC receives Professor Miroslaw Medal from Polish Academy of Sciences

Researchers identify critical mechanism to improve survival and behavior of new brain cells

Researchers identify novel therapeutic approach for most frequent genetic cause of ALS

Research findings may lead to new treatments, approaches for controlling multiple sclerosis

Oligomeric proanthocyanidin has protective effect on retinal ganglion cells, shows study

Scientists identify new toxic entity associated with dementia and motor neuron disease

Cellectricon to demonstrate Cellaxess technology at Neuroscience 2013

NIH selects two leading researchers to chair panels at geroscience symposium

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Video gaming increases spatial orientation, memory formation and motor skills

Rutgers scientists provide new information about rare genetic childhood disorder

Whitehead Institute scientists identify novel Parkinson's disease drug target

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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