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Understanding antibiotic resistance mechanisms in Mycobacterium species

Announcing a new article publication for BIO Integration journal. Tuberculosis (TB) is caused by Mycobacterium tuberculosis (M.tb) complex (MTBC), which includes M.tb as one of the causative bacteria.

3 Jun 2025

Autophagy-based mechanism provides insight into Parkinson’s disease protein secretion

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

23 May 2025

Researchers prolong ketamine’s antidepressant benefits to two months

Roughly 10 percent of the U.S. population is afflicted with major depressive disorder at any given time, and up to 20 percent will exhibit MDD symptoms over their lifetimes.

22 May 2025

Sucralose disrupts male fertility by damaging sperm and altering hormones in animal study

Researchers found that chronic sucralose exposure in male rats disrupted reproductive hormones, damaged sperm, and impaired testicular function through oxidative stress and autophagy dysregulation. These findings raise concerns about the reproductive risks of high sucralose intake and its persistent presence in the environment.

19 May 2025

New drug candidate disrupts the link between herpes virus and Alzheimer’s disease

Studies suggesting that certain viral infections may influence the onset of Alzheimer's diseases are gaining attention. In this context, a domestic research team has succeeded in breaking the link between viral infection and Alzheimer's disease using a new treatment candidate.

16 May 2025

New technology maps molecules within single cells to uncover disease mechanisms

Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease.

14 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

Gene-edited immune cells show promise against advanced GI cancers

Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers.

3 May 2025

Lysosomal lipid peroxidation drives ferroptosis in cancer cells

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

2 May 2025

Intravenous therapy promotes survival of heart muscle cells after a heart attack

Researchers have developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure.

25 Apr 2025

Obesity alters the rhythm of liver’s starvation response

Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network.

22 Apr 2025

Lipid metabolism as a driver of therapy resistance in triple negative breast cancer

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

20 Apr 2025

Unmasking Nrf2 as a key driver of treatment resistance in osteosarcoma

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance.

20 Apr 2025

Magnolia essential oil fights bacteria and oxidative stress with natural potency

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17 Apr 2025

Low vitamin D levels damage erectile health via superoxide surge, study finds

Vitamin D deficiency directly causes erectile dysfunction by increasing superoxide and reducing protective SLPI levels, as shown in human tissue and animal models. This breakthrough reveals why low vitamin D may lead to poor sexual health and resistance to standard ED treatments.

15 Apr 2025

Study identifies a new key factor contributing to aggressive nature of pancreatic cancer

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates-only 10% after five years.

15 Apr 2025

Study shows minimal lean muscle mass loss with GLP-1 and GLP-1/GIP therapy for weight loss

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that patients using GLP-1 or combined GLP-1 / GIP receptor agonist therapy for weight loss experienced minimal lean muscle mass loss as they lost weight across 6 months of treatment.

9 Apr 2025

Breakthrough nanoparticle delivery method targets brain inflammation for multiple conditions

Oregon State University researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer's disease, multiple sclerosis, Parkinson's disease and cancer cachexia.

9 Apr 2025

Study: Jumbo phages utilize EPI vesicles to evade bacterial immune response

In a growing global trend, bacteria have evolved new ways to maneuver around medical treatments for a variety of infections. The rising antibiotic resistance crisis poses a significant public health threat in hospitals and other settings, with infections resulting in millions of deaths in recent years.

4 Apr 2025

New genetic discovery sheds light on PHTS-related vascular malformations

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner.

31 Mar 2025