Mouse Model News and Research

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Ion channel TRPV4 found to regulate relief after scratching an itch

When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels "enough," is not accidental.

22 Feb 2026

New maps of mouse brains reveal patterns of myelin formation

Johns Hopkins scientists say they have used 3D imaging, special microscopes and artificial intelligence (AI) programs to construct new maps of mouse brains showing a precise location of more than 10 million cells called oligodendrocytes.

22 Feb 2026

Discovery offers hope for reducing immune-related heart risks in cancer patients

For many people diagnosed with cancer, treatment with immune checkpoint inhibitors (ICIs) has dramatically extended lives.

20 Feb 2026

Developmental ANGPTL4 deficiency protects mice from colitis and tumors

A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development triggers a long-lasting reprogramming of the immune system that protects against intestinal inflammation.

18 Feb 2026

Researchers develop new score to predict the risk of liver cancer

Researchers led by Xian-Yang Qin at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have developed a score that predicts the risk of liver cancer.

17 Feb 2026

Fred Hutch scientists reach crucial milestone in blocking Epstein Barr virus

Fred Hutch Cancer Center scientists reached a crucial milestone in blocking Epstein Barr virus (EBV), a pathogen estimated to infect 95% of the global population that is linked to multiple types of cancer, neurodegenerative diseases and other chronic health conditions.

17 Feb 2026

ARVCF gene deletion leads to abnormalities in reward behavior

The ventral tegmental area (VTA) is a key brain region for dopamine production and the regulation of reward-related behaviors.

13 Feb 2026

Novel antibody 007 targets the elusive HIV envelope epitope

HIV-1 can be neutralized by antibodies which bind to vulnerable structures on the virus surface. One such vulnerable site is the so-called V3 glycan site of the viral envelope protein.

13 Feb 2026

Airborne toxin exposure drives unique biological pattern of chronic rhinosinusitis

Researchers at the University of California San Diego and the Veterans Affairs San Diego Healthcare System have identified a distinct biological pattern of chronic rhinosinusitis (CRS), a chronic respiratory illness frequently associated with exposure to airborne toxins, such as wildfire smoke and military burn pits.

11 Feb 2026

Study uncovers immune trigger behind vaccine-induced immune thrombocytopenia and thrombosis

A global research collaboration of scientists from McMaster University (Canada), Flinders University (Australia) and Universitätsmedizin Greifswald (Germany) uncovered why a small number of people developed dangerous blood clots after either receiving certain COVID‑19 vaccines or experiencing a natural adenovirus infection, and the answer lies in an unexpected case of misdirected targeting by the immune system.

11 Feb 2026

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Researchers engineered CD4+ chimeric antigen receptor T cells targeting fibrillar amyloid beta and tested them in a mouse Alzheimer model. The preclinical study showed reduced amyloid pathology and altered neuroimmune responses, supporting CAR-T immunotherapy as a potential future Alzheimer strategy.

11 Feb 2026

Shared brainwave biomarker bridges mouse and human fragile X research

Numerous potential treatments for neurological conditions, including autism spectrum disorders, have worked well in lab mice but then disappointed in humans.

11 Feb 2026

Sustained high progesterone during pregnancy can improve menstrual cyclicity in PCOS patients

Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and anovulatory infertility.

11 Feb 2026

New nanoparticles enable the removal of melanoma tumors with low-power laser

Researchers at Oregon State University have developed and tested in a mouse model a new type of nanoparticle that enables the removal of melanoma tumors with a low-power laser.

10 Feb 2026

Defective fat cells drive metabolic disease in lipodystrophy

Many people may have a dim view of their fat tissue, yet scientists have come to recognize adipose as a necessary and metabolically active organ, carrying out many vital functions within the body.

9 Feb 2026

Study reveals how two key proteins contribute to abnormal bone growth after injury

After serious injuries, burns, fractures, or major surgeries, the body normally repairs damaged tissues and restores movement.

9 Feb 2026

Electroacupuncture relieves pain-induced anxiety through prefrontal neural circuits

Neuropathic pain, caused by injury or disease of the somatosensory nervous system, is a major clinical challenge and often evolves into a chronic condition.

7 Feb 2026

Study elucidates key steps in the ubiquitin tagging of mutated huntingtin protein

Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies.

5 Feb 2026

Inhibiting PTP1B protein improves memory in Alzheimer’s disease models

Alzheimer's disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions.

5 Feb 2026

Too many antioxidants may negatively affect future offspring

Antioxidants have been marketed as miracle supplements, touted for preventing chronic diseases and cancers; treating COPD and dementia; and slowing aging.

4 Feb 2026

Mouse Model News and Research

Ion channel TRPV4 found to regulate relief after scratching an itch

New maps of mouse brains reveal patterns of myelin formation

Discovery offers hope for reducing immune-related heart risks in cancer patients

Developmental ANGPTL4 deficiency protects mice from colitis and tumors

Researchers develop new score to predict the risk of liver cancer

Fred Hutch scientists reach crucial milestone in blocking Epstein Barr virus

ARVCF gene deletion leads to abnormalities in reward behavior

Novel antibody 007 targets the elusive HIV envelope epitope

Airborne toxin exposure drives unique biological pattern of chronic rhinosinusitis

Study uncovers immune trigger behind vaccine-induced immune thrombocytopenia and thrombosis

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Shared brainwave biomarker bridges mouse and human fragile X research

Sustained high progesterone during pregnancy can improve menstrual cyclicity in PCOS patients

New nanoparticles enable the removal of melanoma tumors with low-power laser

Defective fat cells drive metabolic disease in lipodystrophy

Study reveals how two key proteins contribute to abnormal bone growth after injury

Electroacupuncture relieves pain-induced anxiety through prefrontal neural circuits

Study elucidates key steps in the ubiquitin tagging of mutated huntingtin protein

Inhibiting PTP1B protein improves memory in Alzheimer’s disease models

Too many antioxidants may negatively affect future offspring

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