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Groundbreaking mouse cortex model opens new frontiers in neuroscience

Harnessing the muscle of one of the world's fastest supercomputers, researchers have built one of the largest and most detailed biophysically realistic brain simulations of an animal ever.

17 Nov 2025

Hypertension may induce early gene expression changes in brain cells

Hypertension impairs blood vessels, neurons and white matter in the brain well before the condition causes a measurable rise in blood pressure, according to a new preclinical study from Weill Cornell Medicine investigators.

14 Nov 2025

Mental navigation framework helps people change pathological thinking

The stereotypical image of psychotherapy shows a patient lying on a couch, exploring their deepest traumas. This leads to awareness of unconscious habits, thoughts, and drives and has long been a cornerstone of psychotherapy.

14 Nov 2025

Scientists debunk gut microbiome-autism connection

There's no scientific evidence that the gut microbiome causes autism, a group of scientists argue in an opinion paper publishing November 13 in the Cell Press journal Neuron.

13 Nov 2025

Stress-induced neuron loss shown to disrupt blood flow and neural communication

While the exact causes of neurodegenerative brain diseases like Alzheimer's and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow.

11 Nov 2025

Preclinical study reveals dampened neuronal activity in alcohol-exposed mice

A psychedelic found in mushrooms is emerging as a potential treatment for alcohol use disorders. This possibility is due to a compound the body converts the psychedelic into called psilocin, but psilocin's mechanisms remain unclear.

11 Nov 2025

Aggression and self-harm could share a common neural basis

Aggression and self-harm often co-occur in individuals with a history of early-life trauma-a connection that has largely been documented by self-reporting in research and clinical settings.

5 Nov 2025

Study reveals how "P bodies" heavily influence a cell's fate

How do stem cells know what to become? Nearly three decades after scientists isolated the first human embryonic stem cells, researchers are still working hard to understand precisely how a single, undifferentiated cell can become any one of the roughly 200 cell types that make up the human body.

4 Nov 2025

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named "Frazzled" (known as DCC in mammals) in the nervous system of fruit flies, showing how it helps neurons connect and communicate with lightning speed.

31 Oct 2025

Mathematical models explain food movement and churning in the digestive tract

Synchronization abounds in nature: from the flashing lights of fireflies to the movement of fish wriggling through the ocean, biological systems are often in rhythmic movement with each other.

31 Oct 2025

How nerve cells in the gut adapt to microbial and immune challenges

Ramnik Xavier, MD, PhD, of the Department of Molecular Biology at Massachusetts General Hospital, is the senior author of a paper published in Science, "Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation."

31 Oct 2025

Enhancing ALS diagnosis with dual blood biomarkers

Despite modern imaging and genetic testing, diagnosing amyotrophic lateral sclerosis (ALS) remains challenging, particularly when distinguishing it from clinically similar neurodegenerative disorders.

29 Oct 2025

Unlocking the secrets of NMDA receptors for better brain health

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell-and the molecular gatekeepers that help control them.

29 Oct 2025

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Peripheral afferent neurons - nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord) - are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

29 Oct 2025