Intracellular News and Research

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Novel vaccine approach to listeria - potential protection against other intracellular bacterial pathogens

When bacterial pathogens attack the surface of a cell, vaccine-induced antibodies can mount a formidable defense and fend off the bad bugs.

21 Mar 2006

EntreMed announces new U.S. Patent - "Estrogenic Compounds as Anti-Mitotic Agents"

EntreMed has announced the issuance of U.S. Patent No. 7,012,070 covering methods of treatment for a broad range of indications with its lead clinical-stage compound, 2-methoxyestradiol (2ME2).

17 Mar 2006

Discovery in yeast opens door to new source of information on DNA damage, repair, and cancer

The discovery in yeast cells of a genetic network that guards against lethal DNA damage is a first step in the creation of a database of disease-causing combinations of mutated human genes, according to researchers at The Johns Hopkins University School of Medicine led by Jef. D. Boeke, Ph.D.

15 Mar 2006

Researchers find viable new sources for stem cell transplants to the heart

Stem cell transplantation is among one of the most exciting and hotly debated areas of medical research today. While the promise of personalized medicine and effective treatments for debilitating diseases drive progress in this area, moral and ethical dilemmas about embryonic cells continues to cloud the field.

14 Mar 2006

Stroke researchers have traced the major cause of the death of brain cells

In the neurological train wreck that is stroke, researchers have traced the major cause of the death of brain cells due to artery blockage or bleeding in the brain.

13 Mar 2006

Components found in red wine can help prevent periodontal diseases

Periodontitis is a progressive infectious disease affecting the gums and bone that surround and support teeth, often causing tooth movement and leading to permanent tooth loss.

13 Mar 2006

Metabolic switch required for cellular adaptation to hypoxia

Two new studies in the March Cell Metabolism reveal a survival mechanism by which cells adapt to oxygen starvation by ratcheting down their demand.

9 Mar 2006

Why people of African descent are more vulnerable to tuberculosis infection

A team of scientists has identified a cellular mechanism that may help explain the puzzle of why people of African descent are more susceptible to tuberculosis infection and why, once infected, they develop more severe states of the disease than whites.

27 Feb 2006

New tool to discover molecules that can enhance or block different kinds of tastes

Researchers from the Monell Chemical Senses Center have succeeded in growing mature taste receptor cells outside the body and for the first time have been able to successfully keep the cells alive for a prolonged period of time.

27 Feb 2006

Scientists put ehrlichiosis under the genomic spotlight

Ehrlichiosis is no star of science. This emerging disease has an awkward name, vague flu-like symptoms, and a nasty habit of being caused by bacteria that live inside ticks and flatworms.

17 Feb 2006

Cancer researchers find evolutionary change that occurred in a key developmental signalling pathway

Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways.

9 Feb 2006

Researchers find new mechanism potentially explaining evolution of signalling pathways

7 Feb 2006

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe-in real-time-the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions.

7 Feb 2006

Key genes identified that enable tuberculosis infection to spread

Scientists in India, led by a Howard Hughes Medical Institute (HHMI) international research scholar, have identified five key genes that enable Mycobacterium tuberculosis to acquire the iron it needs to sustain growth and promote infection

5 Feb 2006

Human body has a unique immune system response to foreign DNA

The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms, Yale School of Medicine researchers report this week in Immunity.

23 Jan 2006

Histidine may be key to new therapies for cardiovascular disease

It's just one little amino acid, but it makes all the difference in protecting the heart from the harmful effects of heart attack and cardiac failure. Researchers from the University of Michigan Medical School suggest this amino acid, called histidine, could be the key to a new therapy for cardiovascular disease

23 Jan 2006

Identification of Gli protein degradation signals that directly affect tumor latency

Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.

22 Jan 2006

Scientists design a fluorescent sensor capable of measuring intracellular acidity

The colouring agents traditionally used to stain organic tissues are no longer sufficient to meet today’s needs. The study of cell metabolism can only advance with better tools than those currently available.

16 Jan 2006

Study explains complex infection fighting mechanism

Yale School of Medicine researchers report in Nature Immunology how infection fighting mechanisms in the body can distinguish between a virus and the healthy body, shedding new light on auto immune disorders.

11 Jan 2006

Aquaporin related to obesity

Dr. Gema Fruhbeck, director of the Metabolic Research Laboratory of the University Hospital of the University of Navarra, has published a commentary in the latest issue of Nature. The article presents aquaporin as a new modulator of the biology of the adipocyte.

21 Dec 2005