Preclinical News and Research

RSS

Anthelmintic inhibits exacerbated inflammatory response related to COVID-19 in preclinical research

Experiments involving animals and human cells conducted at the University of São Paulo (USP) in Brazil suggest that niclosamide, an anthelmintic widely used against tapeworms, effectively inhibits SARS-CoV-2 replication as well as the exacerbated inflammatory response that leads to death in many patients with severe COVID-19.

21 Oct 2022

Duke biomedical engineers develop a two-pronged approach to treating pancreatic cancer

Biomedical engineers at Duke University have demonstrated the most effective treatment for pancreatic cancer ever recorded in mouse models.

21 Oct 2022

Study develops a strategy to noninvasively track tumor-associated macrophages

A Ludwig Cancer Research study has developed a strategy to noninvasively track immune cells known as macrophages within brain and breast tumors in living mice.

19 Oct 2022

Rare insect-eating mushrooms show potential to develop new anti-viral and cancer medications

Scientists studying the medicinal potential of a rare insect-eating mushroom have found a way to grow the elusive fungi in the lab, opening the way for the development of new anti-viral and cancer medications.

19 Oct 2022

Study shows the importance of both obesity and biological sex in COVID-19 outcomes

A new animal study from Katherine Lee, a researcher with the West Virginia University School of Medicine, investigates why individuals with obesity may have a particularly difficult time fending off SARS-CoV-2, the virus that causes COVID-19.

19 Oct 2022

Scientists detect monkeypox virus in the testes of macaques during acute infection

For the first time, scientists have detected monkeypox virus in the testes of macaques during the acute phase of infection, according to research published online today in the journal Nature Microbiology.

17 Oct 2022

Genetic signature predicts tumor metastases and patient survival in clear cell kidney cancer

Among patients with kidney cancer, the activity of four specific genes in the cancer cells seems to be able to predict the risk of the tumor spreading and the patient's chances of survival.

17 Oct 2022

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Researchers presented an overview of factors influencing emerging infectious diseases. They also highlighted the importance of molecular dynamic (MD) simulations and molecular docking (MDO) analysis for combating these diseases.

17 Oct 2022

Inhalation therapeutics against COVID-19

A recent study published in the Pulmonary Pharmacology & Therapeutics journal described different inhalation therapeutic agents for treating respiratory viral infections like coronavirus disease 2019 (COVID-19).

17 Oct 2022

In silico studies identify potent plant metabolites capable of inhibiting SARS-CoV-2

In silico studies assess the binding efficacy of phytoconstituents against active sites of SARS-CoV-2.

16 Oct 2022

Pain-sensing neurons protect the gut from inflammation and associated tissue damage

Neurons that sense pain protect the gut from inflammation and associated tissue damage by regulating the microbial community living in the intestines, according to a study from researchers at Weill Cornell Medicine.

14 Oct 2022

Experimental cancer drug shows promise as a treatment for idiopathic pulmonary fibrosis

Researchers have shown that the medication saracatinib shows promise as a treatment for idiopathic pulmonary fibrosis (IPF).

13 Oct 2022

Potent antibiotic-loaded bone-cement could be used to treat bone infections

Each year, 700,000 people die due to antibiotic resistance. A growing global population unfortunately generates a growing resistance to established antibiotic treatments - a threat that has been met with insufficient funding and dwindling inspiration, as commercial incentives for developing new antibiotics have fallen.

13 Oct 2022

Preclinical News and Research

Anthelmintic inhibits exacerbated inflammatory response related to COVID-19 in preclinical research

Duke biomedical engineers develop a two-pronged approach to treating pancreatic cancer

Study develops a strategy to noninvasively track tumor-associated macrophages

Rare insect-eating mushrooms show potential to develop new anti-viral and cancer medications

Study shows the importance of both obesity and biological sex in COVID-19 outcomes

Scientists detect monkeypox virus in the testes of macaques during acute infection

Genetic signature predicts tumor metastases and patient survival in clear cell kidney cancer

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Inhalation therapeutics against COVID-19

In silico studies identify potent plant metabolites capable of inhibiting SARS-CoV-2

Pain-sensing neurons protect the gut from inflammation and associated tissue damage

Experimental cancer drug shows promise as a treatment for idiopathic pulmonary fibrosis

Potent antibiotic-loaded bone-cement could be used to treat bone infections

Research shows how a very low dose of rhenium metal complex kills ovarian cancer cells

Study offers a systems biology strategy to facilitate the search for effective COVID-19 drugs

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

Clinical trials of novel COVID-19 vaccine developed in Brazil to begin soon

Intranasal vaccine represents an effective broad-spectrum COVID-19 vaccine strategy

The neuroprotective potential of Cannabis sativa L. against Alzheimer's disease

Researchers discover potential therapeutic target for deadly brain tumors

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics