Clinical Trial News and Research

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Study shows effects of year-long heavy resistance training on vital leg strength

Twelve months of heavy resistance training - exercise that makes muscles work against a force - around retirement preserves vital leg strength years later, show the follow up results of a clinical trial, published online in the open access journal BMJ Open Sport & Exercise Medicine.

19 Jun 2024

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

An analysis of data from a randomized clinical trial for patients with stage 3 colon cancer found that those with PIK3CA mutations who took celecoxib, an anti-inflammatory drug, after surgery lived significantly longer and had longer disease-free survival compared to those without the mutation.

18 Jun 2024

GPT-4 enhances clinical trial screening accuracy and cuts costs

Researchers evaluated the RECTIFIER system, a RAG-enabled GPT-4, which showed high accuracy and efficiency in screening clinical trial participants for heart failure, outperforming traditional methods in certain aspects.

18 Jun 2024

Oral semaglutide proves effective for type 2 diabetes and weight loss in Dutch study

A recent study from the PIONEER REAL Netherlands trial demonstrated that oral semaglutide effectively manages type 2 diabetes and supports weight loss in adults.

18 Jun 2024

Nicotinamide riboside boosts walking endurance in peripheral artery disease

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

18 Jun 2024

Older women are different than older men. Their health is woefully understudied.

Medical research has shortchanged women for decades. This is particularly true of older women, leaving physicians without critically important information about how to best manage their health.

18 Jun 2024

New research explores maternal influence on brain biomarkers

A new study by investigators from Mass General Brigham suggests that whether a person inherits risk of Alzheimer's disease from their mother or father influences risk of biological changes in the brain that lead to disease. By evaluating 4,400 cognitively unimpaired adults ages 65-85, the team found those with a history of Alzheimer's disease (AD) on either their mother's side or both parents' sides had increased amyloid in their brains. Their results are published in JAMA Neurology.

18 Jun 2024

New AI tool could revolutionize clinical trial efficiency and cost

Generative Artificial Intelligence (Gen AI) can rapidly and accurately screen patients for clinical trial eligibility, according to a new study from Mass General Brigham researchers. Such technology could make it faster and cheaper to evaluate new treatments and, ultimately, help bring successful ones to patients.

17 Jun 2024

Innovative bread formulation shows promise in preventing asthma

Brazilian researchers have developed functional bread with the potential to prevent asthma, a respiratory disorder responsible for some 350,000 hospitalizations per year in the SUS (Sistema Único de Saúde), the nation's public healthcare network.

17 Jun 2024

Long-term benefits of plant-based diet and lifestyle intervention in RA patients

The 16-week Plants for Joints trial investigated the effects of a multidisciplinary lifestyle intervention in people with RA, as compared to usual care.

16 Jun 2024

Promising gene editing therapy shows hope in sickle cell disease cure

Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.

14 Jun 2024

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University.

14 Jun 2024

EULAR launches ENTRI initiative to boost rheumatic disease research across Europe

The European Alliance of Associations for Rheumatology (EULAR) is proud to announce the launch of the EULAR Network of TRIal Centres (ENTRI) initiative.

14 Jun 2024

Blood-based biomarkers could revolutionize Alzheimer's diagnosis and treatment

A recent review outlines the necessary factors for widespread implementation and interpretation of Alzheimer's disease blood-based biomarkers (BBMs) at the population level, emphasizing the potential for early detection and improved diagnosis.

14 Jun 2024

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

While CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission.

13 Jun 2024

AI-driven alerts improve patient care escalation and survival rates in hospitals

Deploying and evaluating a machine learning intervention to improve clinical care and patient outcomes is a key step in moving clinical deterioration models from byte to bedside, according to a June 13 editorial in Critical Care Medicine that comments on a Mount Sinai study published in the same issue.

13 Jun 2024

Study sheds light on pediatric DIPG tumor mechanisms

Researchers at the University of Michigan Health Rogel Cancer Center are one step closer to understanding how pediatric DIPG tumors work.

13 Jun 2024

Study advocates for liberal blood transfusions in TBI intensive care

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life.

13 Jun 2024

New psychotherapy shows promise in reducing chronic pain for older veterans

A new study led by UCLA Health and the U.S. Veterans Affairs Office found chronic pain among older adults could be significantly reduced through a newly developed psychotherapy that works by confronting past trauma and stress-related emotions that can exacerbate pain symptoms.

13 Jun 2024

Study demonstrates efficacy of treat-to-target in early axial spondyloarthritis

Early therapeutic interventions in inflammatory rheumatic diseases have proven successful in inducing drug-free remission, and EULAR - The European Alliance of Associations for Rheumatology - recommends early intervention in arthritis, since conventional synthetic disease-modifying antirheumatic drugs (csDMARD) have been shown to slow disease progression in both rheumatoid and psoriatic arthritis.

13 Jun 2024

Clinical Trial News and Research

Study shows effects of year-long heavy resistance training on vital leg strength

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

GPT-4 enhances clinical trial screening accuracy and cuts costs

Oral semaglutide proves effective for type 2 diabetes and weight loss in Dutch study

Nicotinamide riboside boosts walking endurance in peripheral artery disease

Older women are different than older men. Their health is woefully understudied.

New research explores maternal influence on brain biomarkers

New AI tool could revolutionize clinical trial efficiency and cost

Innovative bread formulation shows promise in preventing asthma

Long-term benefits of plant-based diet and lifestyle intervention in RA patients

Promising gene editing therapy shows hope in sickle cell disease cure

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

EULAR launches ENTRI initiative to boost rheumatic disease research across Europe

Blood-based biomarkers could revolutionize Alzheimer's diagnosis and treatment

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

AI-driven alerts improve patient care escalation and survival rates in hospitals

Study sheds light on pediatric DIPG tumor mechanisms

Study advocates for liberal blood transfusions in TBI intensive care

New psychotherapy shows promise in reducing chronic pain for older veterans

Study demonstrates efficacy of treat-to-target in early axial spondyloarthritis

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