Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Charity funding awarded to new study aiming to prevent kidney damage in patients with diabetes

Charity funding has been awarded for a major new study which will aim to prevent glucose-induced damage to kidney function in people with diabetes.

12 Sep 2016

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

9 Sep 2016

Viral vector-based approaches could improve effectiveness of CFTR gene therapy

Cystic fibrosis (CF) is characterized by accumulation of thick mucus in the lungs and is associated with a high incidence of bacterial infection. Mutations in the gene encoding CF transmembrane conductance regulator (CFTR) underlie the disease.

9 Sep 2016

Simplified approach to TAVI holds potential to save lives of many patients with rheumatic heart disease

A novel heart valve replacement method is revealed today that offers hope for the thousands of patients with rheumatic heart disease who need the procedure each year. The research is being presented at the SA Heart Congress 2016

9 Sep 2016

Study evaluates long-term safety of infants after maternal MRI exposure

In an analysis that included more than 1.4 million births, exposure to magnetic resonance imaging (MRI) during the first trimester of pregnancy compared with nonexposure was not associated with increased risk of harm to the fetus or in early childhood, although gadolinium MRI at any time during pregnancy was associated with an increased risk of a broad set of rheumatological, inflammatory, or skin conditions and, possibly, for stillbirth or neonatal death, according to a study appearing in the September 6 issue of JAMA.

6 Sep 2016

New discovery could potentially lead to treatments for Crohn's disease

Scientists at the University of British Columbia have made a discovery that could potentially lead to treatments for a debilitating complication of Crohn's disease.

2 Sep 2016

Myeloid-derived suppressor cells may serve as biomarkers for idiopathic pulmonary fibrosis

Researchers at Helmholtz Zentrum München, a partner in the German Center for Lung Research, have discovered that the number of myeloid-derived suppressor cells (MDSC) is increased in the blood of patients with idiopathic pulmonary fibrosis (IPF).

2 Sep 2016

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Researchers at the National Center for Advancing Translational Sciences recently identified compounds that potentially can be used to inhibit Zika virus replication and reduce its ability to kill brain cells.

29 Aug 2016

Boehringer Ingelheim and Duke expand collaboration to create largest patient registry for idiopathic pulmonary fibrosis (IPF)

Boehringer Ingelheim Pharmaceuticals, Inc. and the Duke Clinical Research Institute (DCRI) announced today the expansion of the Idiopathic Pulmonary Fibrosis – PROspective Outcomes (IPF-PRO) Registry, a patient registry developed to uncover insights into IPF, a rare and serious lung disease. The expansion will increase the study enrollment from 300 patients at 18 study sites to 1,500 patients at approximately 45 sites, creating the largest registry of newly diagnosed IPF patients.

29 Aug 2016

Engineered gut bacteria may one day help reduce negative health effects of obesity

A new therapy that involves engineered gut bacteria may one day help reduce the health problems that come with obesity. Incorporating the engineered bacteria into the guts of mice both kept them from gaining weight and protected them against some of the negative health effects of obesity.

28 Aug 2016

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

PGS, Preimplantation Genetic Screening, is a genetic test that analyses biopsied cells from embryos produced by in vitro fertilization (IVF) techniques. PGS determines whether the embryos are chromosomally normal (euploid) or not (aneuploid), thus giving the chance to transfer chromosomally normal embryos that are more apt to successfully implant and develop into a pregnancy.

24 Aug 2016

VUMC receives $11 million renewal grant to advance pulmonary fibrosis research

Vanderbilt University Medical Center has received an $11 million program project renewal grant from the National Heart, Lung and Blood Institute to study the genetics and underlying biological mechanisms that lead to idiopathic pulmonary fibrosis (IPF).

23 Aug 2016

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Food provides us with a variety of substances we need to maintain life. These substances are essential nutrients and are classified as macronutrients (water, protein, fats, and carbohydrates) and micronutrients (vitamins and minerals).

22 Aug 2016

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure.

18 Aug 2016

Hydrothermal DMR results show promise in treatment of type 2 diabetes

Fractyl Laboratories Inc. (Fractyl) announced today publication of data in the current issue of Diabetes Care from the Company’s first-in-human study of RevitaTM duodenal mucosal resurfacing (Revita DMR).

17 Aug 2016

Study explains long-term pulmonary outcomes among childhood cancer survivors

A team of researchers from nine leading academic hospitals and research centers have published a paper in the early online edition of the journal Cancer that describes pulmonary outcomes among childhood cancer survivors.

16 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

UH biologists developing strategies to help regenerate heart muscle cell formation

Cardiovascular diseases are the leading cause of death in the U.S. With one in every four deaths occurring each year, the five-year survival rate after a heart attack is worse than most cancers.

10 Aug 2016

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death.

9 Aug 2016

Reproductive age-related changes in ovarian environment may contribute to infertility

Women's decreased ability to produce healthy eggs as they become older may be due to excessive scarring and inflammation in their ovaries, reports a new Northwestern Medicine study in mice.

8 Aug 2016

Fibrosis News and Research

Further Reading

Charity funding awarded to new study aiming to prevent kidney damage in patients with diabetes

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

Viral vector-based approaches could improve effectiveness of CFTR gene therapy

Simplified approach to TAVI holds potential to save lives of many patients with rheumatic heart disease

Study evaluates long-term safety of infants after maternal MRI exposure

New discovery could potentially lead to treatments for Crohn's disease

Myeloid-derived suppressor cells may serve as biomarkers for idiopathic pulmonary fibrosis

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Boehringer Ingelheim and Duke expand collaboration to create largest patient registry for idiopathic pulmonary fibrosis (IPF)

Engineered gut bacteria may one day help reduce negative health effects of obesity

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

VUMC receives $11 million renewal grant to advance pulmonary fibrosis research

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Hydrothermal DMR results show promise in treatment of type 2 diabetes

Study explains long-term pulmonary outcomes among childhood cancer survivors

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

UH biologists developing strategies to help regenerate heart muscle cell formation

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Reproductive age-related changes in ovarian environment may contribute to infertility

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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