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CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

A single infusion of a CRISPR-based gene-editing therapy significantly reduced low-density lipoprotein cholesterol (LDL, the "bad cholesterol") in people who carry one gene for the inherited condition that results in very high LDL cholesterol levels and a high risk of heart attack at an early age, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Pioneering study finds predictive biomarker in lung adenocarcinoma

The potential of the transcriptome of tumor-adjacent normal lung tissue in predicting the prognosis of lung cancer.

13 Nov 2023

Willow bark may be the source of a new antiviral drug

Scientists have found that specially processed samples of willow bark extract have an antiviral effect which isn’t seen in already known medical compounds from willow bark, such as salicylic acid, the precursor to modern aspirin.

13 Nov 2023

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

In a comprehensive multi-ancestry GWAS meta-analysis, researchers identified 451 risk variants for prostate cancer, including 187 new variants, demonstrating the utility of such studies across diverse populations. This analysis not only increased understanding of genetic risk factors but also differentiated between aggressive and non-aggressive prostate cancer types, underscoring the potential of genetic risk scoring in guiding screening and early detection strategies.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

New insights into migraine etiology: the role of hepatocyte growth factor

The causal links between pro-inflammatory cytokine expression and migraine.

10 Nov 2023

New research aims to decipher how animals discard half their genes

New research is underway to decipher a fascinating biological puzzle - how some animals can naturally discard more than half of their genetic information during embryonic development.

9 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk - 451 in all - through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

9 Nov 2023

Scientists discover kidney-friendly antifungal that evades resistance

In this investigation, researchers produced powerful antifungals of the polyene class without nephrotoxicity.

9 Nov 2023

Unlocking secrets of aging: ENABL age offers detailed, individualized aging profiles using cutting-edge AI techniques

Combining machine learning with explainable artificial intelligence (XAI) to predict biological age with personalized explanations.

9 Nov 2023

Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups.

8 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study on actionable genotypes detected in the Icelandic population and their association with lifespan.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Study provides insights into the epidemiology and genetics of clonal hematopoiesis

A comprehensive new study from deCODE genetics, a subsidiary of Amgen, published today in Nature Genetics, provides insights into the epidemiology and somatic and germline genetics of clonal hematopoiesis.

7 Nov 2023

DZNE neuroscientist awarded 1.5 million euros to investigate biophysical phenomena relevant to brain diseases

Dr. Dragomir Milovanovic, a neuroscientist at DZNE's Berlin site, has been awarded an European Research Council (ERC) "Starting Grant" worth 1.5 million euros to investigate biophysical phenomena relevant to brain diseases in a groundbreaking research project.

7 Nov 2023

To what extent can genetic variations explain the associations between screen time and psychiatric problems in children?

Researchers investigated the role of genetics in the phenotypic association between screen time and psychiatric problems using a large population-based cohort study of preadolescents.

7 Nov 2023

Study links gut bacteria single-nucleotide polymorphisms to BMI

Researchers investigated the potential implications of single-nucleotide variations in gut-residing bacterial species (microbiome) on human health.

7 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Genome News and Research

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

Pioneering study finds predictive biomarker in lung adenocarcinoma

Willow bark may be the source of a new antiviral drug

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

New insights into migraine etiology: the role of hepatocyte growth factor

New research aims to decipher how animals discard half their genes

Tumor-immune interactions predict treatment responses in multiple myeloma

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

Scientists discover kidney-friendly antifungal that evades resistance

Unlocking secrets of aging: ENABL age offers detailed, individualized aging profiles using cutting-edge AI techniques

Genetic melting pot: Study unveils complex admixture in European ancestry populations

Cannabis use alters DNA methylation, with implications beyond smoking effects

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Pharmacogenomics holds promise for personalized dementia therapies

Study provides insights into the epidemiology and genetics of clonal hematopoiesis

DZNE neuroscientist awarded 1.5 million euros to investigate biophysical phenomena relevant to brain diseases

To what extent can genetic variations explain the associations between screen time and psychiatric problems in children?

Study links gut bacteria single-nucleotide polymorphisms to BMI

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

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