Immune System News and Research

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Vitamin K prevents age-related conditions

An important analysis conducted by Children's Hospital Oakland Research Institute scientists suggests the importance of ensuring optimal dietary intakes of vitamin K to prevent age-related conditions such as bone fragility, arterial and kidney calcification, cardiovascular disease, and possibly cancer. Vitamin K is concentrated in dark green plants such as spinach or Swiss chard, and is either not present or present in only small amounts in most multivitamin pills.

18 Sep 2009

Also in global health news: HIV/AIDS in Bangladesh; river blindness in Tanzania; potential immune system booster; compounds might fight TB

BDNews24.com reports on a new $13 million U.S.-government initiative aimed at "providing HIV-prevention services to two million at-risk people in Bangladesh including injecting drug users, male, female and transgender sex workers and their clients, and HIV-positive people through a network of 50 health centres." USAID will partner with Family Health International (FHI) to implement the program (9/17).

18 Sep 2009

Early detection of Alzheimer's can prevent disease progression

More than 5.3 million Americans are living with Alzheimer's, and every 71 seconds someone in America develops the disease.

18 Sep 2009

Preventive treatment extension after kidney transplantation reduces the risk of CMV disease

For kidney transplant recipients, infection with a virus called cytomegalovirus (CMV) may lead to devastating complications. New research suggests that extending the period of preventive treatment after kidney transplantation can reduce the risk of CMV disease, according to an upcoming report in the Journal of the American Society of Nephrology (JASN).

18 Sep 2009

Quebec research on contagious period of H1N1 patients to be presented

Members of a group of Quebec researchers will be presenting the preliminary results of their work on Influenza A (H1N1) tomorrow at the Interscience Conference on Antimicrobial Agents and Chemotherapy, a prestigious international conference that the American Microbiology Association is currently presenting in San Francisco.

18 Sep 2009

Research reveals binge drinking weakens the body's ability to fight off infection

As if a bad hangover wasn't enough of a deterrent, new research has shown how binge drinking weakens the body's ability to fight off infection for at least 24 hours afterwards. The study, published today in the open access journal BMC Immunology, focused on the effect of heavy drinking on toll-like receptor 4 (TLR4), a protein that has an important role in immune system activation.

17 Sep 2009

Research reveals that reactive oxygen inhibition can limit cancer cell invasion

Researchers at the Burnham Institute for Medical Research (Burnham) have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis.

17 Sep 2009

CI Index of ten leading cancer immunotherapy stocks increase by 58% in two months

The Cancer Immunotherapy Index of ten leading cancer immunotherapy stocks has increased 58% in its first two months of reporting. CI Index gain was paced by the 233% share price improvement of ImmunoCellular Theraputics, Inc. (IMUC.OB) under the leadership of CEO Manish Singh, Ph. D.

17 Sep 2009

Liver transplantation performed in a six-month old infant

Ila and her worried parents were referred to Lucile Packard Children's Hospital at Stanford, home of the busiest pediatric liver transplant team in the nation. The hospital's team performed more liver transplants in 2008 – the most recent reporting period – than any other U.S. children's hospital, according to the United Network for Organ Sharing. They also did the largest number of surgeries in infants like Ila, who were younger than one year when they received a transplant.

17 Sep 2009

Findings may lead to drugs that destroy TB in dormant stage of lifecycle

Attempts to eradicate tuberculosis (TB) are stymied by the fact that the disease-causing bacteria have a sophisticated mechanism for surviving dormant in infected cells. Now, a team of scientists led by researchers from Weill Cornell Medical College has identified compounds that inhibit that mechanism -- without damaging human cells.

17 Sep 2009

Researchers investigate individual's ability to get rid of Hepatitis C

More than seventy percent of people who contract Hepatitis C will live with the virus that causes it for the rest of their lives and some will develop serious liver disease including cancer. However, 30 to 40 percent of those infected somehow defeat the infection and get rid of the virus with no treatment. In this week's Advanced Online Publication at Nature, Johns Hopkins researchers working as part of an international team report the discovery of the strongest genetic alteration associated with the ability to get rid of the infection.

17 Sep 2009

Researchers discover HIV Nef protein's role in cell mobility inhibition

In order to be able to ward off disease pathogens, immune cells must be mobile and be able to establish contact with each other. The working group around Professor Dr. Oliver Fackler in the Virology Department of the Hygiene Institute of the Heidelberg University Hospital has discovered a mechanism in an animal model revealing how HIV, the AIDS pathogen, cripples immune cells: Cell mobility is inhibited by the HIV Nef protein.

17 Sep 2009

CEL-SCI to commence its LEAPS-H1N1 clinical trial following FDA approval

CEL-SCI Corporation (NYSE Amex: CVM), a developer of vaccines and therapeutics for the prevention and treatment of infectious diseases and a late-stage oncology company, announced today that the U.S. Food and Drug Administration (FDA) has indicated that the Company can proceed with its first clinical trial to evaluate the effect of its investigational LEAPS-H1N1 treatment on the white blood cells of hospitalized H1N1 patients.

16 Sep 2009

Decision Resources forecasts sales of Rituxan/MabThera, Erbitux and Herceptin

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, forecasts that U.S. and European (France, Germany, Italy, Spain and U.K.) sales of Roche/Biogen Idec's Rituxan/MabThera, Bristol-Myers Squibb/Merck's Erbitux and Roche's Herceptin will peak at almost $16 billion in 2014, before falling to roughly $10 billion in 2018.

16 Sep 2009

Precise T cell correlates of protection need to be identified for vaccine design

T cells are key players in the immune response to HIV, which are able to delete infected cells. This capacity is used for vaccine development against HIV. "To date however, success of this strategy remains elusive. Our understanding of T cell efficacy is still limited, and we need to identify precise T cell correlates of protection that could guide rationale vaccine design", says Victor Appay, Group leader HIV Pathogenesis and Immunosenescence, Hopital Pitie-Salpetriere, Paris, at the 2nd European Congress of Immunology ECI 2009 in Berlin.

16 Sep 2009

MDVIP's medical director suggests preventive measures for flu

Dr. Bernard Kaminetsky, the medical director of MDVIP, a national network of affiliated primary care doctors focused on preventive care, recommends, “Talk to your primary care physician now about the flu, both seasonal and H1N1 flu. Your primary care doctor is the one who can best prepare you for the upcoming season with vaccinations as well as information specific to you.”

16 Sep 2009

Legislation grants improve research and employment initiatives in Indiana University medical campus

Indiana University School of Medicine scientists have received more than $12 million in grants funded by the federal economic stimulus legislation, funding that has bolstered both research initiatives and research employment on the medical center campus.

16 Sep 2009

Toll-like receptors that activate immune cells being developed as alternative cure to cancer

A Toll-like receptor (TLR) agonist, called imiquimod, which activates dendritic cells, is in clinical use as a topical application for basal cell carcinoma. In addition, a number of TLR agonists have been evaluated in clinical trials as an adjuvant for cancer vaccines.

16 Sep 2009

Effective steps to prevent the further spread of E. Coli outbreaks

News that a large and growing outbreak of highly toxic E. coli O157:H7 linked to the Gladstone Farm and Playbarn in Surrey, England has led E. coli expert Bill Marler to urge animal exhibitors on both sides of the Atlantic to implement existing safety guidelines.

16 Sep 2009

Immune response at tumour site predicts cancer progression in colorectal cancer patients

The immune reaction at tumour site determines cancer evolution and clinical outcome in patients with colorectal cancer, regardless of the local extent and spread of the tumour, according to the findings of Jérôme Galon, INSERM Research Director, Paris, and co-workers.

16 Sep 2009

Immune System News and Research

Vitamin K prevents age-related conditions

Also in global health news: HIV/AIDS in Bangladesh; river blindness in Tanzania; potential immune system booster; compounds might fight TB

Early detection of Alzheimer's can prevent disease progression

Preventive treatment extension after kidney transplantation reduces the risk of CMV disease

Quebec research on contagious period of H1N1 patients to be presented

Research reveals binge drinking weakens the body's ability to fight off infection

Research reveals that reactive oxygen inhibition can limit cancer cell invasion

CI Index of ten leading cancer immunotherapy stocks increase by 58% in two months

Liver transplantation performed in a six-month old infant

Findings may lead to drugs that destroy TB in dormant stage of lifecycle

Researchers investigate individual's ability to get rid of Hepatitis C

Researchers discover HIV Nef protein's role in cell mobility inhibition

CEL-SCI to commence its LEAPS-H1N1 clinical trial following FDA approval

Decision Resources forecasts sales of Rituxan/MabThera, Erbitux and Herceptin

Precise T cell correlates of protection need to be identified for vaccine design

MDVIP's medical director suggests preventive measures for flu

Legislation grants improve research and employment initiatives in Indiana University medical campus

Toll-like receptors that activate immune cells being developed as alternative cure to cancer

Effective steps to prevent the further spread of E. Coli outbreaks

Immune response at tumour site predicts cancer progression in colorectal cancer patients

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