Therapy News and Research

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SGO and ASCO release clinical practice guidelines on ovarian cancer treatment

This week the Society of Gynecologic Oncology and the American Society of Clinical Oncology issued a joint clinical practice guideline on ovarian cancer treatment.

12 Aug 2016

Multi-user virtual reality world can improve communication in stroke survivors with aphasia

A virtual reality world called EVA Park can improve the communication of those who have impaired speech and language following a stroke, according to research by academics at City University London.

12 Aug 2016

Former SpaceX engineers launch Synthego, CRISPRevolution to accelerate genome engineering research

Synthego, a leading provider of genome engineering solutions, officially launches today. Synthego’s flagship product line, CRISPRevolution, features synthetic guide RNA products designed to accelerate CRISPR/Cas9 and Cpf1 genome engineering research. CRISPRevolution is the first product line to offer economical access to fully synthetic RNA for high fidelity editing and increased precision in genome editing.

12 Aug 2016

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

BCL-2 inhibitor shows promise in AML patients

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.

12 Aug 2016

Long-term brain-machine interface use could lead to recovery in paraplegic patients

During the 2014 FIFA World Cup opening ceremony, a young Brazilian man, paralyzed from the chest down, delivered the opening kickoff. He used a brain-machine interface, allowing him to control the movements of a lower-limb robotic exoskeleton.

12 Aug 2016

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Researchers from the University Health Network's Department of Anesthesia and Pain Management and the Institute for Clinical Evaluative Sciences have determined that patients who have not had an opioid prescription within a year prior to their procedure are at low risk of developing persistent opioid use after major surgery.

11 Aug 2016

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

11 Aug 2016

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

A major milestone was reached when nusinersen, an investigational treatment for spinal muscular atrophy (SMA), was shown to significantly improve achievement of motor milestones in babies with infantile-onset SMA, according to an interim analysis of the double-blind, randomized, placebo controlled Phase 3 clinical trial called ENDEAR.

11 Aug 2016

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers have used CRISPR -- a revolutionary new genetic engineering technique -- to convert cells isolated from mouse connective tissue directly into neuronal cells.

11 Aug 2016

USC researchers discover two Zika proteins potentially responsible for microcephaly

USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases in Brazil and elsewhere — taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads.

11 Aug 2016

Antioxidant compound could be effective to combat immune rejection after islet transplantation

A team of researchers has found that doses of bilirubin help provide suppression of the immune response following islet transplantation in mouse models.

11 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

New drug provides considerable added benefit in treating adults with advanced renal cell cancer

Nivolumab has been approved since April 2016 as a checkpoint inhibitor for the treatment of adults with advanced renal cell cancer who have already undergone prior therapy.

11 Aug 2016

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

Ospemifene (tradename: Senshio) is approved for the treatment of moderate to severe symptomatic vulvovaginal atrophy (VVA) in post-menopausal women who are not candidates for local vaginal oestrogen therapy.

11 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

Coordinated treatment for both illnesses could save lives of people with HIV and TB

Tuberculosis (TB) is a leading killer of people with HIV, and providing therapy for both illnesses simultaneously saves lives - according to new guidelines on the treatment of drug-susceptible TB developed jointly by the American Thoracic Society, Centers for Disease Control and Prevention and Infectious Diseases Society of America.

11 Aug 2016

Scientists create stable boron carrier for targeted radiation-based tumour therapies

Targeted radiation-based therapies for treating cancerous tumours such as 'boron neutron capture therapy' (BNCT), rely on the efficient and effective delivery of the capture agent (in this case, boron) to the tumour.

11 Aug 2016

American Urologic Association releases new guidelines for surgical treatment of patients with renal stones

A new guideline for the surgical management of patients with kidney and/or ureteral stones has been released by the American Urologic Association.

10 Aug 2016

Therapy News and Research

SGO and ASCO release clinical practice guidelines on ovarian cancer treatment

Multi-user virtual reality world can improve communication in stroke survivors with aphasia

Former SpaceX engineers launch Synthego, CRISPRevolution to accelerate genome engineering research

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

BCL-2 inhibitor shows promise in AML patients

Long-term brain-machine interface use could lead to recovery in paraplegic patients

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

USC researchers discover two Zika proteins potentially responsible for microcephaly

Antioxidant compound could be effective to combat immune rejection after islet transplantation

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

New drug provides considerable added benefit in treating adults with advanced renal cell cancer

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Coordinated treatment for both illnesses could save lives of people with HIV and TB

Scientists create stable boron carrier for targeted radiation-based tumour therapies

American Urologic Association releases new guidelines for surgical treatment of patients with renal stones

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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