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Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections.

10 Nov 2021

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

A new study assesses the antiviral activity of stenoparib against four SARS-CoV-2 strains.

10 Nov 2021

The autoantibody profile in COVID-19 patients with MIS-C

A new study assessed the presence of autoantibodies against autoantigens associated with known autoimmune diseases in patients with COVID-19.

10 Nov 2021

Novel tetravalent antibodies for the ultrapotent and broad neutralization of SARS-CoV-2 variants

Researchers from the University of Toronto set out to create a new tetravalent antibody that could bind with enough potency that it could remain effective against VOCs.

9 Nov 2021

Invalidation of potential SARS-CoV-2 protease inhibitors

Researchers identified several structurally disparate compounds that can inhibit the viral protease PLpro and determined whether the identified PLpro inhibitors are truly effective and should be further investigated.

9 Nov 2021

Non-invasive breathing support to treat COVID-19 does not pose higher risk of infection

New research has found that the use of non-invasive breathing support to treat moderate to severe COVID-19 infection, isn’t linked to a heightened infection risk, as currently thought.

9 Nov 2021

Scientists develop a high-throughput, cell-free screening platform for anti-SARS-CoV-2 antibody discovery

Scientists from Northwestern University, USA, have recently developed a high-throughput, automated screening platform to rapidly identify anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. The study is currently available on the bioRxiv* preprint server.

8 Nov 2021

Discovery of potent neutralizing antibodies against SARS-CoV-2 variants

In a recent study, the researchers identify and characterize mAbs that are effective against the wild-type SARS-CoV-2 strain and B.1.351 variant.

8 Nov 2021

Hemin as a potential therapy for COVID-19

The current study explores the antiviral activity of HO-1 induced by hemin against SARS-CoV-2 and attempts to describe the mechanism of its anti-viral action.

8 Nov 2021

SARS-CoV-2 Nsp1 deletions affect protein stability and translation inhibition

A new study discusses the purification of various Nsp1 proteins isolated from several mutated variants of SARS-CoV-2.

8 Nov 2021

Rapid antibody response induced by mRNA COVID vaccines in mice

A new study posted in the bioRxiv* preprint server used mouse models to investigate how mRNA vaccines elicit a rapid antibody response. Their findings show two different mRNA vaccines successfully boost antibody levels — IL-5, IL-6, and MCP-1 —5 days after administration.

7 Nov 2021

Convalescent plasma post-vaccination increases binding and neutralizing antibodies against SARS-CoV-2 variants

A recent study assesses the boost in antibodies against SARS-CoV-2)variants post-vaccination in plasma samples from previously infected COVID-19 patients.

7 Nov 2021

Murine hepatitis virus as a surrogate for studying SARS-CoV-2 in food processing biofilms

Researchers from Texas A&M University inoculated MHV (SARS-CoV-2 surrogate) into a meat processing environmental biofilm and developed it on stainless steel (SS), PVC, and tiles at 7°C.

4 Nov 2021

Development of SARS-CoV-2 detection platform using surface-enhanced Raman spectroscopy

Researchers have tried to develop an innovative platform for ultrasensitive and rapid detection of SARS-CoV-2 by exploiting a variation of Raman Spectroscopy.

4 Nov 2021

Identification of novel SARS-CoV-2 alpha variant sub-lineage in Europe

Scientists from Germany have recently identified a new sub-lineage of the alpha variant of SARS-CoV-2 in some European countries.

4 Nov 2021

Cas13 shines a light on SARS-CoV-2 variants

Now, a new study published on the medRxiv* preprint server describes and benchmarks SHINEv2, a Cas13-based nucleic acid diagnostic for SARS-CoV-2 detection. SHINEv2 combines temperature sample processing and lyophilized reagents to simplify the test procedure and assay distribution immensely.

4 Nov 2021

The influence of SARS-CoV-2 vaccination time on antibody response in healthcare workers

In this study, the researchers observed a significant effect of time of vaccination on the vaccine-induced SARS-CoV-2 immunity, which was estimated by measuring the anti-Spike antibody levels.

2 Nov 2021

Humoral and cell-mediated immunity six months post BNT162b2 vaccination

A recent study has evaluated vaccine-induced humoral and cellular immunity against SARS-CoV-2 six months post BNT162b2 (Pfizer-BioNTech) vaccination.

2 Nov 2021

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

A new study aimed to identify several potent neutralizing RBD-directed and NTD-directed mAbs that used a nanoparticle displaying the S glycoprotein to capture SARS-CoV-2-specific B cells.

2 Nov 2021

SARS-CoV-2 variants neutralized by camel nanobodies

Researchers from the US recently isolated two VHH nanobodies - 7A3 and 8A2 - from dromedary camels (Camelus dromedaries) using phage display. These nanobodies were found to have a high affinity for the spike RBD and broad neutralization abilities against SARS-CoV-2 and its variants.

2 Nov 2021

Assay News and Research

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

The autoantibody profile in COVID-19 patients with MIS-C

Novel tetravalent antibodies for the ultrapotent and broad neutralization of SARS-CoV-2 variants

Invalidation of potential SARS-CoV-2 protease inhibitors

Non-invasive breathing support to treat COVID-19 does not pose higher risk of infection

Scientists develop a high-throughput, cell-free screening platform for anti-SARS-CoV-2 antibody discovery

Discovery of potent neutralizing antibodies against SARS-CoV-2 variants

Hemin as a potential therapy for COVID-19

SARS-CoV-2 Nsp1 deletions affect protein stability and translation inhibition

Rapid antibody response induced by mRNA COVID vaccines in mice

Convalescent plasma post-vaccination increases binding and neutralizing antibodies against SARS-CoV-2 variants

Murine hepatitis virus as a surrogate for studying SARS-CoV-2 in food processing biofilms

Development of SARS-CoV-2 detection platform using surface-enhanced Raman spectroscopy

Identification of novel SARS-CoV-2 alpha variant sub-lineage in Europe

Cas13 shines a light on SARS-CoV-2 variants

The influence of SARS-CoV-2 vaccination time on antibody response in healthcare workers

Humoral and cell-mediated immunity six months post BNT162b2 vaccination

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

SARS-CoV-2 variants neutralized by camel nanobodies

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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