Efficacy News and Research

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Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research , a journal of the American Association for Cancer Research.

8 Feb 2009

How electronic medical records can be used to test drug efficacy

For years controversy has surrounded whether electronic medical records (EMR) would lead to increased patient safety, cut medical errors, and reduce healthcare costs.

8 Feb 2009

FDA approves orphan drug ATryn anticoagulant

The U.S. Food and Drug Administration has issued its first approval for a biological product produced by genetically engineered (GE) animals.

8 Feb 2009

Study tests salsalate anti-inflammatory for poorly controlled type 2 diabetes

Researchers in 20 medical centers across the country are enrolling adults with type 2 diabetes who have poorly controlled blood glucose to participate in a clinical study, Targeting Inflammation with Salsalate in Type 2 Diabetes (TINSAL-T2D).

5 Feb 2009

Safinamide significantly improved motor function in patients with advanced Parkinson's disease

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, and its partner Newron Pharmaceuticals SpA has announced that the first Phase III trial of investigational agent safinamide as adjunctive therapy to levodopa (study 016) met its primary endpoint by increasing daily "ON" time in mid- to late-stage Parkinson's disease patients with motor fluctuations by 1.3 hours.

5 Feb 2009

FDA grants priority review of Cinryze C1 inhibitor as treatment for acute attacks of hereditary angioedema

ViroPharma Incorporated has announced that the U.S. Food and Drug Administration (FDA) has granted priority review for Cinryze C1 Inhibitor (human) as a treatment for acute attacks of Hereditary Angioedema (HAE).

5 Feb 2009

African-Americans aware and accepting, but often do not receive, the HPV vaccine

Although only 25 percent of eligible African-American adolescents have received the HPV vaccine, a new survey presented at the American Association for Cancer Research conference on the Science of Cancer Health Disparities, suggests they have a positive view of the treatment and might respond to more education.

5 Feb 2009

New test predicts how breast cancer patients respond to chemotherapy

Researchers at the Swiss Institute of Bioinformatics and the Swiss National Center of Competence in Research in Molecular Oncology in Lausanne have developed a new test to predict how breast cancer patients respond to chemotherapy, which could help change how treatment is delivered in the future.

3 Feb 2009

Green tea may counteract anticancer effects of cancer therapy, bortezomib (Velcade)

Green tea products have become regarded as a valuable health supplement, as studies have shown evidence of its benefit against a variety of diseases, including cancer.

3 Feb 2009

SSRIs may reduce the risk of suicide in depressed adults

Selective serotonin reuptake inhibitors (SSRIs) may reduce the risk of suicide in depressed adults, according to a study by researchers from the World Health Organization and the University of Verona, Italy published in CMAJ http://www.cmaj.ca/press/pg291.pdf.

2 Feb 2009

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

Chemotherapy is an integral part of modern cancer treatment, but it's not always effective.

2 Feb 2009

A framework for major depressive disorder

Genes, psychological adversity in childhood, and recent or ongoing psychological stress may combine to cause major depression, write Dr. Sanjay Mathew and colleagues from Mount Sinai School of Medicine in New York in a review published in CMAJ.

2 Feb 2009

Genetic change prevents cell death in mouse model of Parkinson's disease

By shifting a normal protective mechanism into overdrive, a University of Wisconsin-Madison scientist has completely shielded mice from a toxic chemical that would otherwise cause Parkinson's disease.

2 Feb 2009

Physical therapists test mechanical arm to help patients recover from stroke, traumatic brain injury

Physical therapists at UT Southwestern Medical Center are evaluating a new mechanical arm that allows people recovering from neurological injuries such as strokes and traumatic brain injury to enter a virtual world where they can repeatedly practice movements needed to regain arm strength and movement.

2 Feb 2009

Bioidentical hormone facts and perspectives

Public confusion of the benefits and risks of hormone therapy was highlighted once again this week on The Oprah Winfrey Show.

2 Feb 2009

Sequential and alternating chemotherapy and radiation equally effective in larynx cancer therapy

Larynx cancer patients treated with alternating cycles of chemotherapy and radiation have similar outcomes to patients treated with chemotherapy followed by radiation, according to data from a randomized controlled trial in the January 27 online issue of the Journal of the National Cancer Institute.

29 Jan 2009

Researchers discover link between brain iron levels and serotonin

Vanderbilt University Medical Center investigators have found a surprising link between brain iron levels and serotonin, a neurotransmitter involved in neuropsychiatric conditions ranging from autism to major depression.

29 Jan 2009

Study shows no standardized approach to epidural steroid injections for back pain

Today at the American Academy of Pain Medicine's 25th Annual Meeting, researchers from University of California at San Diego report that no standardized practices exist for administering an epidural steroid injection for back pain. Researchers looked at many factors including: which steroids were given, the amount of steroid used, and whether or not a local anesthetic was mixed with the steroid.

29 Jan 2009

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief. It also holds promise in multiple drug delivery options including nasal spray, transdermal patch, and pills. Data were presented today at the American Academy of Pain Medicine's 25th Annual Meeting.

29 Jan 2009

Drug-coated stents less risky for heart bypass patients

Coronary bypass surgery may carry less risk of serious complications if stents coated with a drug that suppresses cell growth are used in the procedure rather than bare-metal stents, UT Southwestern Medical Center researchers and colleagues have found.

23 Jan 2009

Efficacy News and Research

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

How electronic medical records can be used to test drug efficacy

FDA approves orphan drug ATryn anticoagulant

Study tests salsalate anti-inflammatory for poorly controlled type 2 diabetes

Safinamide significantly improved motor function in patients with advanced Parkinson's disease

FDA grants priority review of Cinryze C1 inhibitor as treatment for acute attacks of hereditary angioedema

African-Americans aware and accepting, but often do not receive, the HPV vaccine

New test predicts how breast cancer patients respond to chemotherapy

Green tea may counteract anticancer effects of cancer therapy, bortezomib (Velcade)

SSRIs may reduce the risk of suicide in depressed adults

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

A framework for major depressive disorder

Genetic change prevents cell death in mouse model of Parkinson's disease

Physical therapists test mechanical arm to help patients recover from stroke, traumatic brain injury

Bioidentical hormone facts and perspectives

Sequential and alternating chemotherapy and radiation equally effective in larynx cancer therapy

Researchers discover link between brain iron levels and serotonin

Study shows no standardized approach to epidural steroid injections for back pain

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Drug-coated stents less risky for heart bypass patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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