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NIH grant to fund development of new gene therapy platform for brain diseases

A two-phase NIH grant will fund research into a new CRISPR-based gene therapy platform that will target genetic brain diseases like Angelman syndrome and H1-4 (HIST1H1E) syndrome.

3 Oct 2023

Genetic testing of one thousand embryos provides insights into human development and IVF

By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.

3 Oct 2023

Genomic testing rates soar for Black patients with prostate cancer after introduction of precision medicine navigators

The presence of a clinical navigator to act as a liaison between people with prostate cancer and the health care system greatly increases the likelihood that patients, especially Black patients, will receive advanced testing that can help predict the severity of their disease and guide treatment, a new study suggests.

3 Oct 2023

Microglial states and their impact on Alzheimer's disease

Researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease.

3 Oct 2023

A better method to predict polygenic inheritance across multiple ancestries

Researchers report the results obtained from the use of a new PRS calculator called CT-SLEB on a multi-national GWAS database.

2 Oct 2023

Study shows consanguinity may raise risk of type 2 diabetes and other common diseases

A new study finds that consanguinity – unions between close relatives – may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder (PTSD).

30 Sep 2023

Cancer cells hijack enhancer DNA to grow faster, study finds

University of Toronto researchers have found that cancer cells can enhance tumor growth by hijacking enhancer DNA normally used when tissues and organs are formed.

29 Sep 2023

New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders.

29 Sep 2023

New artemisinin-resistant malaria parasite detected in Eritrea

Diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests and treatment with artemisinin derivatives, the main component of the malaria treatments recommended by the World Health Organization (WHO), are under threat in the Horn of Africa.

29 Sep 2023

New research uncovers autozygosity's impact on common disease risks

Researchers explored the associations between autozygosity, measured as the fraction of the genome in runs of homozygosity (FROH), and common diseases, focusing on populations with high consanguinity rates.

29 Sep 2023

New research reveals how social isolation impacts behavior and lifespan in social species

Researchers used Camponotus fellah (carpenter ants) as a model species to perform behavioral tracking and ribonucleic acid-sequencing (RNA-seq) to study the transcriptome-level differences between socially isolated workers versus workers in groups.

29 Sep 2023

Sushi and other raw seafood can spread antibiotic-resistant bacteria, study warns

Bacteria in raw seafood can make you sick. Seafood can also spread bacteria that are resistant to antibiotics.

28 Sep 2023

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.

28 Sep 2023

Mothers' psychosocial stress during pregnancy has negative associations with children's sleep

Study shows that mothers' psychosocial stress during pregnancy has negative associations with their children's sleep that persist across childhood.

28 Sep 2023

New multi-polygenic scores boost coronary heart disease prediction accuracy

Two multi-polygenic scores (muti-PGs) to predict coronary heart disease (CHD).

28 Sep 2023

New study reveals genetic overlap between schizophrenia and cardiovascular disease risk factors

New research finds that people with schizophrenia have a genetic propensity to smoking and a reduced genetic risk of obesity.

27 Sep 2023

Genetic markers could help identify people at risk for metabolic dysfunction-associated steatotic liver disease

An astounding 30% of Americans currently have metabolic dysfunction-associated steatotic liver disease, or MASLD, which is formerly known as nonalcoholic fatty liver disease, or NAFLD.

27 Sep 2023

Could baseline gut microbiota predict the immune responses elicited by COVID-19 vaccines?

Researchers characterized the gut microbiota composition associated with the durability of COVID-19 vaccine-induced immunity.

27 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

Genome News and Research

NIH grant to fund development of new gene therapy platform for brain diseases

Genetic testing of one thousand embryos provides insights into human development and IVF

Genomic testing rates soar for Black patients with prostate cancer after introduction of precision medicine navigators

Microglial states and their impact on Alzheimer's disease

A better method to predict polygenic inheritance across multiple ancestries

Study shows consanguinity may raise risk of type 2 diabetes and other common diseases

Cancer cells hijack enhancer DNA to grow faster, study finds

New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

New artemisinin-resistant malaria parasite detected in Eritrea

New research uncovers autozygosity's impact on common disease risks

New research reveals how social isolation impacts behavior and lifespan in social species

Sushi and other raw seafood can spread antibiotic-resistant bacteria, study warns

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Mothers' psychosocial stress during pregnancy has negative associations with children's sleep

New multi-polygenic scores boost coronary heart disease prediction accuracy

New study reveals genetic overlap between schizophrenia and cardiovascular disease risk factors

Genetic markers could help identify people at risk for metabolic dysfunction-associated steatotic liver disease

Could baseline gut microbiota predict the immune responses elicited by COVID-19 vaccines?

Arrayed CRISPR Screening for Revolutionizing Target Discovery

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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