Central Nervous System News and Research

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Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial.

23 May 2016

ULK1, ULK2 enzymes play key role in maintaining cellular homeostasis

Researchers at St. Jude Children's Research Hospital have uncovered how two enzymes, ULK1 and ULK2, which are best known for their role in the degradation and recycling of proteins, control the trafficking of specific proteins.

23 May 2016

Maternal pregabalin exposure linked to major birth defect risk

First trimester exposure to pregabalin may be associated with an increased risk of major birth defects, an observational study suggests.

19 May 2016

Understanding antibody transport mechanisms in the brain

Diseases of the central nervous system (CNS), such as stroke, brain cancer, and Alzheimer's disease, are a serious threat affecting over 50 million Americans with an associated cost of over $750 billion per year, which is expected to grow significantly over the coming decades.

19 May 2016

Taking pregabalin drug during pregnancy could lead to major birth defects

A drug commonly used to treat pain, epilepsy, anxiety and other brain health disorders may be associated with an increased risk of major birth defects, according to a study published in the May 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology.

19 May 2016

Conventional repeated radiation treatments may offer no major benefit to brain tumor patients

A new study shows that repeated radiation therapy used to target tumors in the brain may not be as safe to healthy brain cells as previously assumed.

19 May 2016

Play-based procedural preparation helps reduce sedation use and costs tied to cranial radiation therapy

New research from St. Jude Children's Research Hospital shows support interventions by child life specialists decrease sedation use and costs associated with cranial radiation therapy.

19 May 2016

Experimental hepatitis C drug slows down development of Zika in mice

Virologists from KU Leuven, Belgium, have shown that an experimental antiviral drug against hepatitis C slows down the development of Zika in mice. The research team was led by Professor Johan Neyts from the Laboratory of Virology and Chemotherapy.

17 May 2016

Neos announces U.S. launch of Adzenys XR-ODT for ADHD

Neos Therapeutics, Inc., a pharmaceutical company with a late‐stage pipeline of innovative extended-release (XR) product candidates for the treatment of attention-deficit/hyperactivity disorder (ADHD), today announced that Adzenys XR-ODT™ is in distribution channels and is now available to prescribe for patients with ADHD in the United States.

16 May 2016

NeuroDerm starts patient enrollment in long-term safety study of ND0612 for treatment of Parkinson’s disease

NeuroDerm Ltd., a clinical stage pharmaceutical company developing drugs for central nervous system disorders, today announced the start of patient enrollment in a long-term safety study (trial 012) of the company’s continuously administered subcutaneous levodopa/carbidopa formulation used in both ND0612H and ND0612L.

13 May 2016

Sheffield Hallam University lecturer to discuss research into cause of fibromyalgia at parliamentary event

A Sheffield Hallam University lecturer will address the Health Secretary and other MPs tomorrow at a parliamentary event that aims to raise awareness of the incurable chronic pain condition, fibromyalgia.

From Sheffield Hallam University 11 May 2016

Older adults become more sensitive to pain, study shows

When older relatives complain about their pains, show a little empathy, because new research suggests that as we age, we may all become more sensitive to pain. A small, preliminary University of Florida Health study has suggested for the first time that inflammation may occur more quickly and at a higher magnitude -- and stays around longer -- when older adults experience pain versus when younger adults experience pain.

5 May 2016

Real risk of rebound syndrome following fingolimod cessation for MS

Rebound syndrome following cessation of fingolimod for multiple sclerosis occurs at a clinically relevant rate, shows research, prompting the need for further study on how best to sequence and discontinue such drugs.

4 May 2016

Changes in the brain make people prone to alcoholism

The brain tissue of persons with alcohol dependence shows a variety of changes compared to non-alcoholic control persons. All alcoholics' brains share some characteristics, but some are exclusive to the brain tissue of anxiety-prone type 1 alcoholics or impulsive type 2 alcoholics, according to a recent study from the University of Eastern Finland.

29 Apr 2016

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

A new version of an obesity drug that caused serious psychiatric side effects could help people lose pounds without experiencing the anxiety, depression and suicidal thoughts previously associated with it. The research, published in Bioorganic and Medicinal Chemistry, shows that the new version of the drug can still work without reaching the brain in rats, avoiding the side effects.

29 Apr 2016

ZOTEN nanoparticles can help develop natural immunity against genital herpes

An effective vaccine against the virus that causes genital herpes has evaded researchers for decades. But now, researchers from the University of Illinois at Chicago working with scientists from Germany have shown that zinc-oxide nanoparticles shaped like jacks can prevent the virus from entering cells, and help natural immunity to develop.

28 Apr 2016

More neurological resources needed to manage Zika virus infections

WFN Zika-Info-Service: World Federation of Neurology establishes Work Group on Zika virus to support international efforts - Lack of neurological resources in countries most concerned by the virus.

28 Apr 2016

RADAR-CNS programme aims to improve lives of patients with brain disorders

A major new research program supported by the Innovative Medicines Initiative launches today, which will develop new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology.

27 Apr 2016

Researchers test potential positive effects of micro-injury in mice modeled with AD

Researchers testing the potential positive effects of "micro-injury" by brief insertion of a small needle into the hippocampal region of mice modeled with Alzheimer's disease (AD) have found that the procedure not only stimulated the hippocampus into regenerative activity, but also reduced β-amyloid plaques, a hallmark of AD.

27 Apr 2016

Scientists derive first molecular model of critical transporter at blood-brain barrier

Scientists from Duke-NUS Medical School have derived a structural model of a transporter at the blood-brain barrier called Mfsd2a. This is the first molecular model of this critical transporter, and could prove important for the development of therapeutic agents that need to be delivered to the brain --- across the blood-brain barrier. In future, this could help treat neurological disorders such as glioblastoma.

25 Apr 2016

Central Nervous System News and Research

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

ULK1, ULK2 enzymes play key role in maintaining cellular homeostasis

Maternal pregabalin exposure linked to major birth defect risk

Understanding antibody transport mechanisms in the brain

Taking pregabalin drug during pregnancy could lead to major birth defects

Conventional repeated radiation treatments may offer no major benefit to brain tumor patients

Play-based procedural preparation helps reduce sedation use and costs tied to cranial radiation therapy

Experimental hepatitis C drug slows down development of Zika in mice

Neos announces U.S. launch of Adzenys XR-ODT for ADHD

NeuroDerm starts patient enrollment in long-term safety study of ND0612 for treatment of Parkinson’s disease

Sheffield Hallam University lecturer to discuss research into cause of fibromyalgia at parliamentary event

Older adults become more sensitive to pain, study shows

Real risk of rebound syndrome following fingolimod cessation for MS

Changes in the brain make people prone to alcoholism

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

ZOTEN nanoparticles can help develop natural immunity against genital herpes

More neurological resources needed to manage Zika virus infections

RADAR-CNS programme aims to improve lives of patients with brain disorders

Researchers test potential positive effects of micro-injury in mice modeled with AD

Scientists derive first molecular model of critical transporter at blood-brain barrier

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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