Clinical Trial News and Research

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Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by modulating gut microbiota.

23 Jul 2024

Study validates Stockholm3 test for prostate cancer in ethnically mixed populations

Stockholm3, a prostate cancer test developed in Sweden, runs a combination of protein and genetic markers from a blood sample through an algorithm to find the probability of a patient having clinically significant cancer.

23 Jul 2024

Abacavir linked to increased cardiovascular risk in HIV patients, study finds

CJ Fichtenbaum et al. Abacavir is associated with elevated risk for cardiovascular events in the REPRIEVE trial. International AIDS Conference. Friday, July 26, 2024

23 Jul 2024

New preclinical model offers a unique platform for studying Parkinson's disease process

A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.

23 Jul 2024

PrEPVacc HIV vaccine trial shows no reduction in infections

The results of the PrEPVacc HIV vaccine trial conducted in Eastern and Southern Africa, which ran between 2020 and 2024, show conclusively that neither of the two experimental vaccine regimens tested reduced HIV infections among the study population.

23 Jul 2024

Combination of sEphB4-HSA and pembrolizumab shows promise in HPV-negative EphrinB2 positive HNSCC

A new research paper was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma."

22 Jul 2024

Synthetic solutions for ethical and effective drug testing

Improving human quality of life with drug treatments is a complicated issue. Drug certification, including drug safety and reliability, entails a long series of tests and government approvals before the drug is available for anyone to use.

22 Jul 2024

Understanding Consumer-Consented Data to Optimize Clinical Trials and Digital Health Programs

In this interview, News Medical speaks with the Healthcare Business of LexisNexis® Risk Solutions about optimizing clinical trial screening and digital health programs through a better understanding of consumer-consented data.

From LexisNexis® Risk Solutions 22 Jul 2024

New combined cell therapy for kidney transplants can help reduce donor-specific immune response

A new combined cell therapy for kidney transplants can help to reduce the donor-specific reaction against the transplanted organ without the need for maintenance triple immunosuppression.

22 Jul 2024

Challenges and opportunities in rare tumor research

Ning Li et al., at Chinese Academy of Medical Sciences and Peking Union Medical College, China, provides a comprehensive review on the challenges and opportunities in the field of rare tumor research and management.

22 Jul 2024

Saffron: A golden remedy for modern health challenges

Review highlights saffron's potential in preventing and treating various human diseases through its bioactive compounds. Clinical and preclinical studies confirm saffron's benefits in conditions like maculopathy, depression, neurodegenerative diseases, and cancer.

21 Jul 2024

Study confirms high success rates of combined chemotherapy in treating testicular cancer

A new study shows that by combining different chemotherapy drugs, testicular cancer remains highly treatable and often curable, even after first-line treatment fails.

19 Jul 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Study reveals a promising approach to developing universal influenza vaccine

New research led by Oregon Health & Science University reveals a promising approach to developing a universal influenza vaccine - a so-called "one and done" vaccine that confers lifetime immunity against an evolving virus.

19 Jul 2024

Mobile apps and wearables show promise in easing mental health symptoms during therapy wait times

The recent surge in people seeking mental health care across the country has led to long wait times for first appointments with therapists and psychiatrists.

18 Jul 2024

New drugs show promise in shrinking breast cancer brain metastases

Researchers from Drexel's College of Medicine have identified new drugs that show early success in shrinking breast cancer tumors that have metastasized in the brain.

18 Jul 2024

Improving medication adherence beats resistance testing for better HIV outcomes in African youth

Globally, around 2.6 million children and adolescents are currently living with HIV, the majority of them in Africa.

18 Jul 2024

Harnessing ctDNA measurements for response assessment in metastatic castration resistant prostate cancer

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer."

18 Jul 2024

Cystic fibrosis drug reduces hyper-inflammation in COVID-19 pneumonia patients

A drug commonly used to treat cystic fibrosis improved outcomes for patients with severe COVID-19 pneumonia and could be used to treat other respiratory infections, according to clinical trial results from researchers at UCL, UCLH and the Francis Crick Institute.

18 Jul 2024

Mindfulness training linked to altered states of consciousness

Mindfulness training may lead participants to experience disembodiment and unity – so-called altered states of consciousness – according to a new study from researchers at the University of Cambridge.

18 Jul 2024

Clinical Trial News and Research

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study validates Stockholm3 test for prostate cancer in ethnically mixed populations

Abacavir linked to increased cardiovascular risk in HIV patients, study finds

New preclinical model offers a unique platform for studying Parkinson's disease process

PrEPVacc HIV vaccine trial shows no reduction in infections

Combination of sEphB4-HSA and pembrolizumab shows promise in HPV-negative EphrinB2 positive HNSCC

Synthetic solutions for ethical and effective drug testing

Understanding Consumer-Consented Data to Optimize Clinical Trials and Digital Health Programs

New combined cell therapy for kidney transplants can help reduce donor-specific immune response

Challenges and opportunities in rare tumor research

Saffron: A golden remedy for modern health challenges

Study confirms high success rates of combined chemotherapy in treating testicular cancer

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

Study reveals a promising approach to developing universal influenza vaccine

Mobile apps and wearables show promise in easing mental health symptoms during therapy wait times

New drugs show promise in shrinking breast cancer brain metastases

Improving medication adherence beats resistance testing for better HIV outcomes in African youth

Harnessing ctDNA measurements for response assessment in metastatic castration resistant prostate cancer

Cystic fibrosis drug reduces hyper-inflammation in COVID-19 pneumonia patients

Mindfulness training linked to altered states of consciousness

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