Mitochondria News and Research

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Comprehensive review on the pharmacology of sigma receptors published in Journal of Pharmacology Therapeutics

Anavex Life Sciences Corp. ("ANAVEX" or the "Company") reports the publication of a comprehensive review of the pharmacology of sigma receptors and their possible clinical application in the peer-reviewed Journal of Pharmacology Therapeutics.

28 Aug 2009

CRi's Oosight imaging system used for developing a gene transfer technique to prevent inherited diseases

U.S. researchers using CRi's Oosight(TM) imaging system have developed a gene transfer technique that has potential to prevent inherited diseases passed on from mothers to their children through mutated DNA in cell mitochondria.

28 Aug 2009

New research results reveal that two Parkinson genes can maintain the mitochondrial functions

Parkinson's disease is caused by the degeneration of neurons in the midbrain. The mechanisms leading to the loss of these neurons, however, are largely unknown. Recent research revealed that about ten per cent of cases are caused by defects in so-called Parkinson-associated genes. Furthermore, mitochondria, the cellular powerhouses, seem to play a major role. New results from researchers at the LMU Munich under the lead of associate professor Dr. Konstanze Winklhofer and Professor Christian Haass connect both phenomena, showing that two Parkinson genes maintain the function of mitochondria.

24 Aug 2009

Researchers find link between chronic kidney disease and impaired mitochondrial respiratory system

Chronic kidney disease (CKD) has been linked to oxidative stress caused by dysregulation of the genes that control mitochondria. A study in the open access journal BMC Genomics has revealed alterations in respiration gene expression in the white blood cells of CKD patients.

21 Aug 2009

Scientists develop new technique to target brain cancer cells

Scientists from the U.S. Department of Energy's (DOE) Argonne National Laboratory and the University of Chicago's Brain Tumor Center have developed a way to target brain cancer cells using inorganic titanium dioxide nanoparticles bonded to soft biological material.

20 Aug 2009

Nano-bio material kills cancer cells, leaves healthy cells in unharmed

19 Aug 2009

High-fat diets just as unhealthy in short term as long term

Short-term memory getting worse? Exercise getting harder? Examine your diet. New research published online in The FASEB Journal showed that in less than 10 days of eating a high-fat diet, rats had a decreased ability to exercise and experienced significant short-term memory loss. These results show an important link between what we eat, how we think, and how our bodies perform.

12 Aug 2009

Discovery of a genetic mutation underlying late-onset Leigh syndrome

Researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University have discovered a genetic mutation underlying late-onset Leigh syndrome, a rare inherited metabolic disorder characterized by the degeneration of the central nervous system.

11 Aug 2009

Changes in mtDNA can cause premature ageing

The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now shown how certain proteins that are synthesised in the cellular mitochondria - popularly known as the cells' power plants - become unstable and disintegrate, which in turn can impair cell respiration and cause premature ageing.

7 Aug 2009

Discovery of a new Alzheimer's gene

A UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.

6 Aug 2009

Unstable proteins can cause premature ageing

The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients.

6 Aug 2009

Repeated stress signals made in cells with metabolism-associated disease encourage the growth of invading bacteria

Mitochondrial diseases disrupt the power generating machinery within cells and increase a person's susceptibility to bacterial infection, particularly in the lungs or respiratory tract.

28 Jul 2009

Estrogen can reduce stroke damage by inactivating a tumor-suppressing protein

Estrogen can halt stroke damage by inactivating a tumor-suppressing protein known to prevent many cancers, Medical College of Georgia researchers say.

17 Jul 2009

Controlling the fate of cells

A protein found in cells has been shown to play a pivotal role in determining whether a cell lives or dies.

13 Jul 2009

Protein regulates movement of mitochondria in brain cells

Scientists have identified a protein in the brain that plays a key role in the function of mitochondria - the part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from disease.The discovery, which was reported today in the Journal of Cell Biology, may shed new light on how the brain recovers from stroke.

15 Jun 2009

Gene variation associated with resistance to chemotherapy drug in women with breast cancer

Researchers have found links between an individual's genetics and their response to treatment with chemotherapy. The findings, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues, show how a genetic variant, located in the SOD2 gene, may affect how a person responds to the chemotherapy drug cyclophosphamide. Cyclophosphamide is used in the treatment of breast and other cancers.

9 Jun 2009

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

Better treatments for acute renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get enough blood or are exposed to toxins, researchers at the Medical College of Georgia report in the may issue of the Journal of Clinical Investigation.

18 May 2009

Mitochondria News and Research

Comprehensive review on the pharmacology of sigma receptors published in Journal of Pharmacology Therapeutics

CRi's Oosight imaging system used for developing a gene transfer technique to prevent inherited diseases

New research results reveal that two Parkinson genes can maintain the mitochondrial functions

Researchers find link between chronic kidney disease and impaired mitochondrial respiratory system

Scientists develop new technique to target brain cancer cells

Nano-bio material kills cancer cells, leaves healthy cells in unharmed

High-fat diets just as unhealthy in short term as long term

Discovery of a genetic mutation underlying late-onset Leigh syndrome

Changes in mtDNA can cause premature ageing

Discovery of a new Alzheimer's gene

Unstable proteins can cause premature ageing

Repeated stress signals made in cells with metabolism-associated disease encourage the growth of invading bacteria

Estrogen can reduce stroke damage by inactivating a tumor-suppressing protein

Controlling the fate of cells

Protein regulates movement of mitochondria in brain cells

Gene variation associated with resistance to chemotherapy drug in women with breast cancer

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

Mitochondrial peptide Humanin linked to neuronal cell survival and regulation of glucose metabolism

Developmental drug protects cells from the damaging effects of radiation exposure

Statins may be useful in patients with tamoxifen-resistant breast cancer

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