Immune System News and Research

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Opposites attract and genetics influence why you choose your partner

Brazilian scientists say they have discovered how humans choose their partners - they say opposites attract and genetics influence how a person chooses a partner.

25 May 2009

Bioniche updates on phase III clinical trial with Urocidin in non-muscle-invasive bladder cancer

Bioniche Life Sciences Inc. has provided an update on its Phase III clinical program evaluating Urocidin(TM) in the treatment of bladder cancer. On March 31st, the Company announced that recruitment had been completed in its initial Phase III registration trial evaluating Urocidin in the treatment of non-muscle-invasive bladder cancer that is refractory (unresponsive) to the current standard immunotherapy - Bacillus Calmette-Guérin (BCG).

25 May 2009

Researchers unlock mystery of potentially fatal reaction to smallpox vaccine

Researchers from the La Jolla Institute for Allergy & Immunology have pinpointed the cellular defect that increases the likelihood, among eczema sufferers, of developing eczema vaccinatum, a severe and potentially fatal reaction to the smallpox vaccine.

25 May 2009

New understanding on how superbugs manipulate the immune system

It appears that some superbugs have evolved to develop the ability to manipulate the immune system to everyone's advantage.

24 May 2009

How genetics influences mate choice in humans

New light has been thrown on how humans choose their partners, a scientist will tell the annual conference of the European Society of Human Genetics today (Monday May 25).

24 May 2009

HHS directs $1 billion towards commercial-scale production of a candidate vaccine for H1N1

HHS Secretary Kathleen Sebelius has announced that the department will take important steps necessary to prepare for potential commercial-scale production of a candidate vaccine for the novel Influenza A ( H1N1).

24 May 2009

Poor vitamin D status linked to common vaginal infection in pregnant women

Pregnant women with low levels of vitamin D may be more likely to suffer from bacterial vaginosis (BV) - a common vaginal infection that increases a woman's risk for preterm delivery, according to a University of Pittsburgh study.

22 May 2009

HER2/neu protein predicts development of invasive breast cancer in women with ductal carcinoma in situ

Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study from the University of Pennsylvania School of Medicine.

22 May 2009

Tuberculosis can evade immune response

Current research suggests that Mycobacterium tuberculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions," appears in the June 2009 issue of The American Journal of Pathology.

22 May 2009

Toddler’s mysterious meningitis trumps cancer threat

Brooklynn Spencer's mother Samantha knew something wasn't right. The 8 month old had the flu recently, but it had been four weeks. She should have been better. The Elmira mother of four pushed for blood tests in early October 2007. A few hours later, there was a knock at the door.

21 May 2009

Arsenic exposure linked to influenza A (H1N1) susceptibility

The ability to mount an immune response to influenza A (H1N1) infection is significantly compromised by a low level of arsenic exposure that commonly occurs through drinking contaminated well water, scientists at the Marine Biological Laboratory (MBL) and Dartmouth Medical School have found.

20 May 2009

Bacteria of the Yersinia genus possess a unique protein thermometer

Bacteria are experts at adaptation: as soon as they have infected an organism, they adapt their metabolism to that of their host and produce substances which protect them from the body's immune defences. How they do this is still unknown in the case of many types of bacteria.

20 May 2009

Genetic signature predicts clinical outcomes in certain types of breast cancer

Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.

19 May 2009

Research may lead to improved TB vaccines

A team of Vanderbilt University Medical Center investigators has cracked one of clinical medicine's enduring mysteries - what happened to the tuberculosis vaccine. The once-effective vaccine no longer prevents the bacterial lung infection that kills more than 1.7 million people worldwide each year.

19 May 2009

Discovery of new target in fight against osteoporosis, periodontitis

Osteoporosis and periodontitis are common diseases whose sufferers must cope with weakness, injury and reduced function as they lose bone more quickly than it is formed. While the mechanism of bone destruction in these diseases is understood, scientists have had less information about how bone formation is impaired.

19 May 2009

Salmonella’s weakness for sugar predicts its downfall

For the first time UK scientists have shown what the food poisoning bug Salmonella feeds on to survive as it causes infection: glucose.

19 May 2009

Relationship discovered between tumors and depression

In a study that could help explain the connections between depression and cancer, researchers at the University of Chicago have used an animal model to find, for the first time, a biological link between tumors and negative mood changes.

18 May 2009

Researchers look at eczema asthma link

Many young children who get a severe skin rash develop asthma months or years later. Doctors call the progression from eczema, or atopic dermatitis, to breathing problems the atopic march. In the May 2009 issue of PLoS Biology, scientists at Washington University School of Medicine in St. Louis report another step taken towards understanding the process of atopic march.

18 May 2009

Disruption of immune-system pathway key step in cancer progression

Human immune cells communicate constantly with one another as they coordinate to fight off infection and other threats.

18 May 2009

Vaccine candidate successful in blocking Simian version of HIV

Researchers have successfully blocked SIV, the simian version of HIV, using a new technique that could help lead to the development of an effective HIV/AIDS vaccine, the Children's Hospital of Philadelphia. The team also included scientists from Nationwide Children's Hospital in Columbus, Ohio, and the New England Primate Research Center in Boston.

18 May 2009