Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

HCV patients with hepatocellular carcinoma history could re-develop illness during or after taking DAAs

Data from a new study show that patients with Hepatitis C virus (HCV) taking direct-acting antiviral treatments (DAAs), who have previously fought off hepatocellular carcinoma (HCC), the most common form of liver cancer,1 had a 'high rate' of re-developing their illness.

13 Apr 2016

New clinical data highlights potential of AB-PA01 to treat P. aeruginosa infections in CF patients

AmpliPhi Biosciences Corporation, a global leader in the development of bacteriophage-based antibacterial therapies to treat drug-resistant infections, presented data at the European Congress of Clinical Microbiology and Infectious Diseases summarizing both the in vitro and in vivo activity of its proprietary, investigational phage mix AB-PA01.

13 Apr 2016

Inserm study reveals potential of secondary system to improve heart function

Heart failure affects over one million people in France. Although the blood system is the first to have been explored for the purpose of improving heart function, a study by Inserm has revealed the potential of a secondary system that had previously received scant attention.

13 Apr 2016

Complete genetic map of scleroderma opens door for diagnosis and targeted treatment

Scleroderma is an autoimmune disease that affects one out of every 10,000 people in Europe and North America, mostly middle-aged women, and causes death in a high percentage of cases.

11 Apr 2016

Scientists develop wearable sweat sensors for medical analysis of sweat

Plants and trees soak up water in the soil by letting it vaporize through pores in the leaves. Scientists at Eindhoven University of Technology (TU/e) have now taken this principle to develop a sweat sensor through which the sweat itself flows at a steady rate and is analyzed.

11 Apr 2016

Researchers identify vital inflammatory mechanisms in type 1 diabetes, obesity-related kidney dysfunction

In a new study, published in the online edition of the journal EBioMedicine, a multi-disciplinary team led by researchers at University of California, San Diego School of Medicine has identified key inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction.

11 Apr 2016

Newcastle scientists develop new type of genetic blood test to diagnose liver scarring

Newcastle scientists and medics have developed a new type of genetic blood test that diagnoses scarring in the liver - even before someone may feel ill.

11 Apr 2016

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Nonalcoholic fatty liver disease, or NAFLD, comprises a group of liver disorders whose prevalence is widespread and rising. It's estimated that at least one-third of Americans have NAFLD; among obese persons, the figure is 50 percent.

6 Apr 2016

Understanding idiopathic pulmonary fibrosis: an interview with Michael Durheim, M.D.

IPF is a rare and fatal lung disease that causes permanent scarring of the lungs, leading to debilitating shortness of breath and cough in affected patients. It affects as many as 132,000 Americans, most commonly those over the age of 65.

4 Apr 2016

Excess activation of LOX may play causative role in progression of cardiac failure

Heart failure is a progressive condition, where structural and functional alterations of the ventricle limit the ability of the heart to either fill or eject blood. There are approximately 550,000 new cases of heart failure each year with a prevalence of nearly 5 million; most patients die within five years of diagnosis.

2 Apr 2016

CCN5 protein reverses cardiac fibrosis in heart failure models

CCN5, a matricellular protein, has been found to reverse established cardiac fibrosis in heart failure models, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai, and Woo Jin Park, PhD, Professor of Life Sciences at the Gwangju Institute of Science and Technology, South Korea.

29 Mar 2016

UT Southwestern scientists discover mutation that causes X-linked reticulate pigmentary disorder

UT Southwestern Medical Center researchers have discovered a mutation that causes a rare systemic disorder known as X-linked reticulate pigmentary disorder (XLPDR) and, significantly, the unexpected cellular mechanism by which the mutation causes the disease.

29 Mar 2016

Simple tips to help parents and children lead a healthy life

Obesity is almost at epidemic proportions; it has more than doubled in children and tripled in adolescents in the past 30 years nationwide. Rosa Cataldo, DO, MPH, Director of the Healthy Weight & Wellness Center at Stony Brook Children's Hospital, says that the most effective approach to addressing weight loss in children are lifestyle-based modifications that involve parents.

26 Mar 2016

Inactivation of protein-coding gene promotes liver tissue regeneration in mammals

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) report that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals.

26 Mar 2016

Wnt secretion inhibitors may reduce renal fibrosis

Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen.

25 Mar 2016

Personalized medicine promises better treatment options for cystic fibrosis patients

For a highly variable disease like cystic fibrosis, personalized medicine promises treatments based on individual factors, down to the molecular level. This promise is especially alluring for the treatment of children with cystic fibrosis, who are at particular risk for complications that could affect them throughout their lives.

25 Mar 2016

SLU researchers discover compound that disrupts fibrotic process

Saint Louis University researchers have found that a type of compound that disrupts the process that causes fibrosis (scarring) in the lungs and liver also shows promise in preventing and treating fibrosis in yet another organ, the pancreas. The research was conducted in an animal model.

23 Mar 2016

Fibrosis News and Research

Further Reading

HCV patients with hepatocellular carcinoma history could re-develop illness during or after taking DAAs

New clinical data highlights potential of AB-PA01 to treat P. aeruginosa infections in CF patients

Inserm study reveals potential of secondary system to improve heart function

Complete genetic map of scleroderma opens door for diagnosis and targeted treatment

Scientists develop wearable sweat sensors for medical analysis of sweat

Researchers identify vital inflammatory mechanisms in type 1 diabetes, obesity-related kidney dysfunction

Newcastle scientists develop new type of genetic blood test to diagnose liver scarring

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Understanding idiopathic pulmonary fibrosis: an interview with Michael Durheim, M.D.

Excess activation of LOX may play causative role in progression of cardiac failure

CCN5 protein reverses cardiac fibrosis in heart failure models

UT Southwestern scientists discover mutation that causes X-linked reticulate pigmentary disorder

Simple tips to help parents and children lead a healthy life

Inactivation of protein-coding gene promotes liver tissue regeneration in mammals

Wnt secretion inhibitors may reduce renal fibrosis

Personalized medicine promises better treatment options for cystic fibrosis patients

SLU researchers discover compound that disrupts fibrotic process

Mucus may hold key to better cancer treatment

VolitionRx's NuQ blood test accurately detects 86% of subjects with Idiopathic Pulmonary Fibrosis

Systemic sclerosis: an interview with Dr Kristin Highland

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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