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New drug combo fights breast cancer with brain metastases

A combination of two HER2-targeted drugs, tucatinib (Tukysa) and trastuzumab emtansine (Kadcyla, T-DM1), extended progression-free survival among patients with unresectable locally advanced or metastatic HER2-positive breast cancer, compared with T-DM1 alone, according to results from the HER2CLIMB-02 trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Ethnic disparities in COVID-19 mortality rates among hospitalized patients in California

The association between race and outcomes in Coronavirus Disease-2019 (COVID-19) hospitalizations in California.

6 Dec 2023

Sympathetic nervous system and immune interplay: Key to metabolic regulation

A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. This comprehensive analysis provides insights into the neuroimmune relationships affecting metabolism, offering potential new therapeutic strategies for metabolic diseases.

5 Dec 2023

UCLA researchers win NCI grants to advance liquid biopsy for early detection of cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center have received two grants totaling $9.1 million from the National Cancer Institute to advance liquid biopsy technologies for the early detection of cancer, which can significantly improve treatment outcomes and reduce the number of deaths caused by the disease.

4 Dec 2023

MAbID offers a deep dive into chromatin dynamics and gene regulation

Researchers from the group of Jop Kind developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease.

4 Dec 2023

Desperate families search for affordable home care

It's a good day when Frank Lee, a retired chef, can slip out to the hardware store, fairly confident that his wife, Robin, is in the hands of reliable help. He spends nearly every hour of every day anxiously overseeing her care at their home on the Isle of Palms, a barrier island near Charleston, South Carolina.

4 Dec 2023

CN Bio PhysioMimix Organ-on-a-Chip data supports Inipharm’s INI-822 for metabolic liver disease treatment now in clinical testing

CN Bio today announced its PhysioMimix® assay for Non-alcoholic steatohepatitis (NASH).

From CN Bio 4 Dec 2023

Study finds high levels of chemicals in hair care products

The average morning routine for many Americans includes inhaling several milligrams of chemicals that may be harmful to their health, Purdue University researchers have found.

4 Dec 2023

Weight loss leads to dynamical changes in brain function and gut microbiome

Worldwide, more than one billion people are obese. Obesity is a risk factor for cardiovascular disease, diabetes, and some cancers. But permanently losing weight isn’t easy: complex interactions between body systems such as gut physiology, hormones, and the brain are known to work against it. One method for weight loss is intermittent energy restriction (IER), where days of relative fasting alternate with days of eating normally.

4 Dec 2023

Scientists warn of potential pitfalls when using the Cre-LoxP system in cancer research

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research."

1 Dec 2023

New drug combination may improve treatment for rare nerve sheath tumors

Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.

1 Dec 2023

Silencing galectin 1 protein shrinks liver cancer tumors in mice

Researchers at UC Davis Comprehensive Cancer Center have shown that inhibiting a specific protein using gene therapy can shrink hepatocellular carcinoma (HCC) in mice.

30 Nov 2023

Greater adherence to lifestyle-based recommendations reduced the risk of cancers in the U.K.

The BMC Medicine study confirms that adhering to the 2018 World Cancer Research Fund/American Institute for Cancer Research recommendations significantly lowers the risk of various cancers, including breast, colorectal, and esophageal, in the UK population. This highlights the importance of lifestyle choices in cancer prevention.

30 Nov 2023

The effects of vitamin K on bone health

Existing scientific data on the effects of vitamin K (VK) on bone health and elucidated the underlying mechanisms.

30 Nov 2023

Study uncovers cell signaling pathway that regulates melanoma brain metastasis

Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body.

29 Nov 2023

Drug-eluting hydrogel has enhanced capabilities for treating hepatocellular carcinoma

Scientists from the Terasaki Institute for Biomedical Innovation (TIBI) have developed an injectable or catheter-administered hydrogel with enhanced capabilities for treating hepatocellular carcinoma (HCC), a deadly form of liver cancer.

29 Nov 2023

Morning hair routine can expose individuals to harmful chemicals, study shows

Researchers conducted realistic-type hair care experiments to assess cyclic volatile methyl siloxane (cVMS) emissions and exposures during hair care product (HCP) use in a residential structure.

29 Nov 2023

Clinical trial reveals dapagliflozin's impact on heart failure and type 2 diabetes management

Researchers conducted a clinical trial on the effects of dapagliflozin on the urinary albumin-to-creatinine ratio (UACR) in patients with heart failure (HF) and type 2 diabetes mellitus (T2D).

29 Nov 2023

Exploring associations between BMI, cardiometabolic diseases, and cancer risk

Researchers evaluate the associations of body mass index, type 2 diabetes, and cardiovascular disease with cancer risk.

29 Nov 2023

Cheers to health: Exploring wine's wellness secrets

A review in the journal "Foods" examines health-promoting compounds in wine and related products, focusing on technological advancements in their detection and study. It aims to inform winemaking and viticulture, enhancing human health benefits while preserving taste.

28 Nov 2023