Membrane News and Research

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Role of S-acylation in SARS-CoV-2 infectivity

A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.

10 Oct 2021

Study supports efficacy and safety of lung-selective nanotherapy against SARS-CoV-2 infection

A new preprint shows the potential role of a host protease cathepsin L inhibitor, which mediates viral entry into the host cell by its effect on the viral spike protein.

8 Oct 2021

Assay to assess and quantify presence of RBD-directed antibodies against SARS-CoV-2 following vaccination

Researchers from Roche Diagnostics have been testing a new assay known as the Elecsys assay.

8 Oct 2021

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

7 Oct 2021

Scientists elucidate the structure of protein complex essential for proper functioning of cells

Scientists at IST Austria describe for the first time the structure of a protein complex essential for our cells to function properly.

7 Oct 2021

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Researchers from Ohio State University have been investigating mutations in the rest of the spike protein, particularly the Q677H mutation.

7 Oct 2021

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Scientists have developed and validated a cell-free fluorescence assay for the rapid screening of protein inhibitors.

7 Oct 2021

Tiny bubbles show promise for reducing inflammation

Scientists hope that tiny sacs of material excreted by cells - so-called extracellular vesicles - can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport protein drugs that reduce inflammation caused by different diseases.

6 Oct 2021

Graphene biosensor in a portable and wireless device for rapid SARS-CoV-2 detection

A new study posted to the medRxiv* server and led by Dr. Mattia D'Agostino, Dr. Eleonora Pavoni and Dr. Alice Romagnoli from the Polytechnic University of Marche in Ancona (Italy), a gFET biosensor that uses angiotensin-converting enzyme 2 (ACE2) as a bioreceptor has been put forth as a viable solution.

6 Oct 2021

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

A new study reported that the ZBP1-induced inflammatory signaling pathway is dependent on ubiquitination and RIPK3’s scaffolding ability, independent of cell death.

5 Oct 2021

Study looks at immunosuppressants and COVID vaccine efficacy

Researchers investigate the effects of five established immunosuppressant medications following COVID-19 vaccination.

4 Oct 2021

mRNA vaccination induces strong humoral immune responses against SARS-CoV-2 in over 80's

A recent study assesses the serological and cellular responses to Pfizer’s BNT162b2 mRNA vaccine in people aged 80-96 years.

4 Oct 2021

Glycerin helps calm the red itchy patches in psoriasis model

Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combatting their psoriasis and now scientists have objective evidence to support their reports.

4 Oct 2021

Study finds cause and solution for complications in peritoneal dialysis

The number of patients suffering from chronic kidney disease or loss of kidney function is increasing worldwide and with it the number of people who need renal replacement therapy.

4 Oct 2021

Prevalence of adaptive and prolonged infections’ mutations in receptor-binding domain of SARS-CoV-2 spike protein

A new study used the available nucleotide sequence data on the NCBI COVID-19 database and estimated the global prevalence of adaptive and prolonged infections' mutations in the RBD of the S protein.

4 Oct 2021

Difficulties of stability and storage of mRNA COVID-19 vaccines

Two researchers have collaborated to review the difficulties faced in storing and transporting these vaccines in a manner that will keep them stable.

4 Oct 2021

Immune response to SARS-CoV-2 variants of concern after natural infection or vaccination

A recent review paper published in the MDPI's journal Viruses highlights how available vaccines may be effective in protecting individuals against severe forms of coronavirus disease 2019 (COVID-19), but the protection against infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its transmission to others may be reduced – with consequences for community protection and herd immunity.

3 Oct 2021

Membrane News and Research

Role of S-acylation in SARS-CoV-2 infectivity

Study supports efficacy and safety of lung-selective nanotherapy against SARS-CoV-2 infection

Assay to assess and quantify presence of RBD-directed antibodies against SARS-CoV-2 following vaccination

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

Scientists elucidate the structure of protein complex essential for proper functioning of cells

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Tiny bubbles show promise for reducing inflammation

Graphene biosensor in a portable and wireless device for rapid SARS-CoV-2 detection

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

Study looks at immunosuppressants and COVID vaccine efficacy

mRNA vaccination induces strong humoral immune responses against SARS-CoV-2 in over 80's

Glycerin helps calm the red itchy patches in psoriasis model

Study finds cause and solution for complications in peritoneal dialysis

Prevalence of adaptive and prolonged infections’ mutations in receptor-binding domain of SARS-CoV-2 spike protein

Difficulties of stability and storage of mRNA COVID-19 vaccines

Immune response to SARS-CoV-2 variants of concern after natural infection or vaccination

Persistent leukocyte changes three months after mild SARS-CoV-2 infection

Structure of monoclonal antibody that can potently neutralize SARS-CoV-2 and variants of concern

Study finds US pediatric COVID-19 cases are higher than expected

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