Mouse Model News and Research

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Modifying a cancer drug has created a new agent for multi-resistant infections

Researchers have modified a cancer drug to create an agent that is effective at treating multi-drug-resistant infections.

16 Dec 2019

Important discovery about male infertility could lead to new treatments

Using a new mouse model, Penn Medicine researchers have identified defects in the sperm epigenome that cause male infertility.

16 Dec 2019

Using new high-resolution imaging to track titin in real time

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body's largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into muscle development as well as treating damaged muscles and heart disease.

14 Dec 2019

New strategy could prevent side effects of targeted cancer treatment

Targeted, highly effective cancer treatments often produce debilitating side effects. This is the case with one commonly used therapy which works by blocking the epidermal growth factor receptor, a protein that stimulates cell proliferation.

13 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Huntington's disease (HD) is an incurable and fatal hereditary disease. Developing disease-modifying drugs to treat patients with HD depends on studying them in animal models. Scientists evaluated the mouse models used for developing new treatments for mood disorders in HD and recommended which of these models are most relevant to their studies.

11 Dec 2019

Research suggests new strategies for developing psoriasis therapies

Psoriasis is a skin disorder that affects at least 100 million individuals worldwide. Its economic impact is more than $10 billion annually in the U.S. alone.

11 Dec 2019

Bruker launches Luxendo TruLive3D Imager light-sheet imaging system

At the 2019 joint meeting of the American Society for Cell Biology and European Molecular Biology Organization, Bruker today announced the launch of the Luxendo TruLive3D Imager light-sheet imaging system.

From Bruker Nano Surfaces and Metrology 11 Dec 2019

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife.

10 Dec 2019

New nanoparticle innovation detects vascular calcification in atherosclerosis

Heart disease and stroke are the world's two most deadly diseases, causing over 15 million deaths in 2016 according to the World Health Organization.

9 Dec 2019

Important biomarker may help in determining prognosis of brain cancer patients

A common virus that is harmless to most individuals may produce an important biomarker in determining the prognosis of brain cancer patients, according to a recent study published by a student researcher at the University of Cincinnati.

9 Dec 2019

New approach to broadly acting, highly effective HIV vaccine

Researchers have reported a major advance in the creation of a successful HIV vaccine that is not produced by the host animal.

9 Dec 2019

Researchers successfully develop imaging technology of conjunctival goblet cells

Goblet cells are epithelial cells that produce mucins and disperse tears which help the surface of eyes maintain the wet environment. Goblet cells are closely related to autoimmune disease including dry eyes and chemical burns. Therefore, it is very important to examine the status of goblet cells to better understand and diagnose ocular disease.

5 Dec 2019

New discovery on chromosomal function may shed light on human health and disease

Researchers have discovered key mechanisms and structural details of a fundamental biological process - how a cell nucleus and its chromosomal material reorganizes itself after cell division

5 Dec 2019

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Researchers have shown that painful endometriosis symptoms could be alleviated using an investigational cancer drug.

3 Dec 2019

Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Painful endometriosis symptoms could be reduced with a cancer drug

The painful symptoms of endometriosis - a chronic condition which affects millions of women - could potentially be reduced with a drug that had previously been investigated as a cancer treatment.

2 Dec 2019

Gene discovery in fruit flies could provide clues to counteract mitochondrial diseases

Scientists have identified a protein in fruit flies that can be targeted to reverse the effects of disease-causing mutations in mitochondrial genes. The discovery could provide clues about how to counteract human mitochondrial diseases, for which there is currently no cure.

28 Nov 2019