Mutation News and Research

RSS

PAXLOVID shown to be highly effective against all SARS-CoV-2 variants

A recent study, currently available on bioRxiv* preprint server, shows that a novel protease inhibitor known as nirmatrelvir has potent activity against Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also other variants evaluated in this paper – which supports its potential role in reducing the disease burden from coronavirus disease 2019 (COVID-19).

21 Jan 2022

Researchers identify first known patients with BUB1 biallelic mutations

A new study published in Science Advances described the first two patients known to have mutations in both copies of BUB1, a critical gene for cell division.

20 Jan 2022

Scientists explore the possibility of Omicron ending the COVID-19 pandemic

A new analysis parses out what scientists currently know about the Delta variant and predicts what the end of the COVID-19 pandemic might look like.

20 Jan 2022

Development of a glycoprotein multi-epitope subunit vaccine candidate against South-African SARS-CoV-2 strains

In a new study, scientists focused on the SARS-CoV-2 Beta variant and used computational methods to design and develop effective glycoprotein multi-epitope subunit vaccine candidates, based on the old and the new Beta virus strains.

20 Jan 2022

Recombinant bat coronavirus reported in wide-ranging Cambodian bat

A new study reports on the detection of recombinant coronaviruses in several bat species in Cambodia and of a related species in China.

20 Jan 2022

Newly developed gene therapy can treat a severe form of epilepsy and prolong survival

Research from the University of Virginia School of Medicine suggests how a newly developed gene therapy can treat Dravet syndrome, a severe form of epilepsy, and potentially prolong survival for people with the condition.

20 Jan 2022

Variants of SARS-CoV-2 and preventive strategies

A recent review article published in the journal Advanced Science reviewed the features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Using a physical and materials science perspective, the review also summarizes the most significant variants of SARS-CoV-2 encountered to date as well as possible preventive strategies.

19 Jan 2022

Scientists reveal toxic astrocyte changes in ALS

Scientists at the Francis Crick Institute have revealed harmful changes in supporting cells, called astrocytes, in Amyotrophic Lateral Sclerosis (ALS) in two publications in Brain and Genome Research.

19 Jan 2022

Rapid DNA sequencing technique used to diagnose rare genetic disease in short time

A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators was used to diagnose rare genetic diseases in an average of eight hours — a feat that's nearly unheard of in standard clinical care.

19 Jan 2022

New method reverses insecticide resistance using CRISPR/Cas9 technology

Insecticides play a central role in efforts to counter global impacts of mosquito-spread malaria and other diseases, which cause an estimated 750,000 deaths each year. These insect-specific chemicals, which cost more than $100 million to develop and bring to market, also are critical to controlling insect-driven damage on crops that poses a challenge to food security.

18 Jan 2022

Scientists assess ACE2 binding and antigenicity of Mu (B.1.621) and A.2.5 spikes

To gain a better understanding of the antigenic properties of Mu and A.2.5 Spikes, Canadian scientists evaluated their capacity to interact with ACE2 and performed binding and neutralization assays with plasma from vaccinated individuals.

18 Jan 2022

Macrodomains represent a unique target for pathogens with pandemic potential

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents.

18 Jan 2022

Research provides new insights on memory loss in Alzheimer's disease

Members of the "Synaptic Dysfunction and Disease" group at the Institute of Biomedicine of Seville, led by researchers Francisco Gómez Scholl and Amalia Martínez Mir, recently published the results of their research into Alzheimer's disease.

18 Jan 2022

New perspective on SARS-CoV-2 breakthrough infections and booster shot restoration of vaccine efficacy

A recent article published in the journal Science explains how SARS-CoV-2 variants can bypass vaccine-induced immune defenses. However, immunity is restorable with a booster shot. The paper's authors outlined the importance of a booster shot in maintaining immunity and preventing severe infection.

18 Jan 2022

Wastewater-based epidemiology to predict emerging new SARS-CoV-2 variants

In a new study, researchers established a strong approach for deducing public health-relevant epidemiological metrics like relative variant abundance and variant-specific reproduction numbers from wastewater (WW)-derived deep sequenced SARS-CoV-2 genomes.

18 Jan 2022

Mutation News and Research

PAXLOVID shown to be highly effective against all SARS-CoV-2 variants

Researchers identify first known patients with BUB1 biallelic mutations

Scientists explore the possibility of Omicron ending the COVID-19 pandemic

Development of a glycoprotein multi-epitope subunit vaccine candidate against South-African SARS-CoV-2 strains

Recombinant bat coronavirus reported in wide-ranging Cambodian bat

Newly developed gene therapy can treat a severe form of epilepsy and prolong survival

Variants of SARS-CoV-2 and preventive strategies

Scientists reveal toxic astrocyte changes in ALS

Rapid DNA sequencing technique used to diagnose rare genetic disease in short time

New method reverses insecticide resistance using CRISPR/Cas9 technology

Scientists assess ACE2 binding and antigenicity of Mu (B.1.621) and A.2.5 spikes

Macrodomains represent a unique target for pathogens with pandemic potential

Research provides new insights on memory loss in Alzheimer's disease

New perspective on SARS-CoV-2 breakthrough infections and booster shot restoration of vaccine efficacy

Wastewater-based epidemiology to predict emerging new SARS-CoV-2 variants

Researchers report isolation of potently neutralizing antibodies against highly transmissible SARS-CoV-2 variants

Study finds evidence to strongly implicate OAS1 as an effector gene influencing COVID-19 severity

Researchers construct models to predict SARS-CoV-2 mutable and constrained positions

Better global health equality could prevent emergence of future SARS-CoV-2 variants of concern

Study suggests vaccinated Omicron cases are unlikely to shed infectious virus 10 days after diagnosis or symptom onset

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Latest News