Opioids News and Research

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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

SAMHSA-funded project to develop a Prescriber's Clinical Support System

Medical professionals will gain access to free clinical support in the use of opioid medications through a new grant announced by SAMHSA today. SAMHSA awarded $1.5 million to the American Academy of Addiction Psychiatry to develop a Prescriber's Clinical Support System.

18 Aug 2011

Pacira second quarter total revenues increase to $3.6 million

Pacira Pharmaceuticals, Inc., an emerging specialty pharmaceutical company, today announced financial results for the second quarter ended June 30, 2011, provided an update on the execution of its pre-commercial and launch strategies for EXPAREL, and updated its 2011 financial guidance.

11 Aug 2011

Positive results from two ADL5945 Phase 2 studies for opioid-induced constipation

Adolor Corporation today announced positive, statistically significant top line results from its two Phase 2 studies of ADL5945 in chronic non-cancer pain patients with opioid-induced constipation.

11 Aug 2011

Health Affairs report describes ground-breaking effort that aims to prevent opioid abuse

Fatal overdoses involving prescribed opioids tripled in the United States between 1999 and 2006, climbing to almost 14,000 deaths annually-more than cocaine and heroin overdoses combined. Hospitalizations and emergency room visits related to prescription opioid pain medicines such as oxycodone and hydrocodone also increased dramatically in the same period.

5 Aug 2011

AstraZeneca recruits patients for KODIAC Phase III trial in opioid-induced constipation

AstraZeneca today announced that study centers across the U.S. are recruiting patients for a clinical study to examine whether an investigational drug is safe and effective in treating opioid-induced constipation.

2 Aug 2011

FDA approves Covidien's morphine sulfate oral solution for chronic pain in opioid-tolerant patients

Covidien, a leading global provider of healthcare products, today announced that the U.S. Food and Drug Administration (FDA) recently granted approval to the company's Mallinckrodt business for morphine sulfate oral solution, used to relieve moderate to severe acute and chronic pain in opioid-tolerant patients. The solution will be available as a generic in 100 milligrams per 5 mL (20 milligrams per 1 mL).

1 Aug 2011

QRxPharma raises A$25 million, announces A$10.4 million Rights Issue

QRxPharma Limited is pleased to announce the successful completion of a placement to institutions and professional investors raising A$25 million which was significantly oversubscribed. The Placement was very well supported by both existing and new investors including Australia, US and UK based fund managers.

25 Jul 2011

BDSI completes BEMA Buprenorphine Phase 3 trial on chronic pain

BioDelivery Sciences International, Inc. announced today that the last patient has completed the randomized portion of its Phase 3 clinical trial assessing the efficacy and safety of BEMA Buprenorphine for the treatment of moderate to severe chronic pain, signifying completion of the trial.

25 Jul 2011

Study explores factors for misuse of prescription opioid in young injection drug users

A new study by researchers at Drexel University's School of Public Health suggests that abuse of prescription painkillers may be an important gateway to the use of injected drugs such as heroin, among people with a history of using both types of drugs.

25 Jul 2011

Homeless people report using street drugs to treat their pain

Chronic pain is not managed well in the general population and it's an even greater challenge for homeless people, according to new research by St. Michael's Hospital.

22 Jul 2011

Study finds high prevalence of prescription pain medication addiction in chronic patients

A new study by Geisinger Health System researchers finds a high prevalence of prescription pain medication addiction among chronic pain patients.

22 Jul 2011

FDA approves Cephalon's REMS for FENTORA, ACTIQ

Cephalon, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved the Risk Evaluation and Mitigation Strategy (REMS) for FENTORA and ACTIQ.

22 Jul 2011

Dealing with chronic pain

For people with severe chronic pain like Kelly Young and Teresa Shaffer—both of whom have become patient advocates —coping with agony is a fact of life. Young suffers from rheumatoid arthritis while Shaffer's pain is linked primarily to another degenerative bone disease.

21 Jul 2011

Essential criteria for clinical diagnosis of restless legs syndrome

We've all experienced abnormal sensations in our legs at one time or another, but for as many as 10 percent of the US population, restless legs syndrome (RLS) is a daily occurrence. Characterized by throbbing, pulling, tingling, itching, and crawling sensations, RLS is a neurological disorder that produces unpleasant physical sensations in the extremities and an urge to counteract that sensation by movement.

21 Jul 2011

Convergence initiates CNV1014802 Phase II study in lumbosacral radiculopathy

Convergence Pharmaceuticals Limited, the company focused on the development of novel and high value analgesic medicines, today announces that the Phase II proof of concept study with CNV1014802 for treating pain associated with lumbosacral radiculopathy (LSR) has started.

19 Jul 2011

QRxPharma seeks NDA approval for MoxDuo IR

QRxPharma Limited announced today initiation of the New Drug Application (NDA) approval process for MoxDuo IR with the United States Food and Drug Administration (FDA). This NDA submission sets the stage for the regulatory approval process for MoxDuo IR for the treatment of moderate to severe acute pain, a $2.5 billion segment of the $8 billion spent annually on prescription opioids in the US.

18 Jul 2011

Obama administration turns bright spotlight on prescription painkiller abuse

The Obama administration turned a bright spotlight on prescription painkiller abuse in April when the Office of National Drug Control Policy released a national action plan and a statement from Vice President Joe Biden.

2 Jul 2011

Bio-Nucleonics' generic Metastron, an option for metastatic cancer bone pain therapy

Bio-Nucleonics' lead product Strontium Chloride Sr-89 Injection USP (Strontium-89), which is the generic version of Metastron®, is an option to consider for metastatic cancer bone pain therapy, typically caused by advanced stage breast, prostate or lung cancer.

28 Jun 2011

Omeros identifies compounds that interact with orphan GPCRs associated with leukemia

Omeros Corporation today reported that it has identified compounds that interact with orphan G protein-coupled receptors (GPCRs) P2Y8 and OPN4. P2Y8 (also known as P2RY8) is associated with acute lymphoblastic leukemia (ALL), an aggressive cancer of the white blood cells.

27 Jun 2011

Endo's complete response for new formulation of OPANA ER NDA accepted by the FDA

Endo Pharmaceuticals announced today that it received notification from the U.S. Food and Drug Administration (FDA) that Endo's complete response to the FDA's Jan. 7, 2011 Action Letter relating to Endo's new drug application (NDA) for a new formulation of OPANA ER has been accepted.

24 Jun 2011

Opioids News and Research

Further Reading

SAMHSA-funded project to develop a Prescriber's Clinical Support System

Pacira second quarter total revenues increase to $3.6 million

Positive results from two ADL5945 Phase 2 studies for opioid-induced constipation

Health Affairs report describes ground-breaking effort that aims to prevent opioid abuse

AstraZeneca recruits patients for KODIAC Phase III trial in opioid-induced constipation

FDA approves Covidien's morphine sulfate oral solution for chronic pain in opioid-tolerant patients

QRxPharma raises A$25 million, announces A$10.4 million Rights Issue

BDSI completes BEMA Buprenorphine Phase 3 trial on chronic pain

Study explores factors for misuse of prescription opioid in young injection drug users

Homeless people report using street drugs to treat their pain

Study finds high prevalence of prescription pain medication addiction in chronic patients

FDA approves Cephalon's REMS for FENTORA, ACTIQ

Dealing with chronic pain

Essential criteria for clinical diagnosis of restless legs syndrome

Convergence initiates CNV1014802 Phase II study in lumbosacral radiculopathy

QRxPharma seeks NDA approval for MoxDuo IR

Obama administration turns bright spotlight on prescription painkiller abuse

Bio-Nucleonics' generic Metastron, an option for metastatic cancer bone pain therapy

Omeros identifies compounds that interact with orphan GPCRs associated with leukemia

Endo's complete response for new formulation of OPANA ER NDA accepted by the FDA

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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