Preclinical News and Research

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Researchers unravel mechanism that underlies failure of staph vaccine trials

For the most part, the bacterium Staphylococcus aureus is common and harmless, posing no threat to humans with whom they coexist.

7 Jul 2022

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

DZNE and Intravacc B.V., a world leading contract development and manufacturing organization (CDMO) of preventive and therapeutic vaccines, have been awarded a funding of € 2.5 million from the European Union (EIC Transition Grant) to further develop a prototype ALS vaccine, including process development, scale-up, and toxicology study.

6 Jul 2022

Scientists discover a key starting point for inhibiting inflammation in psoriasis and psoriatic arthritis

Around 250,000 people in Austria suffer from psoriasis. One third of them develop inflammation in their joints (psoriatic arthritis) as a result of the chronic skin condition.

6 Jul 2022

Running faster and dreaming help your left brain and right brain to communicate better

You’re out jogging and suddenly notice a low-hanging tree branch in your path. You quickly lower your head, narrowly avoiding the branch, and continue on the run without giving it another thought.

6 Jul 2022

Latest omicron subvariants are better at eluding vaccines and antibody treatments

The latest omicron subvariants - including the BA.4 and BA.5 forms causing new surges in infections in the United States - are even better at eluding vaccines and most antibody treatments than previous variants, finds a study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

5 Jul 2022

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study publishing July 5th in the open-access journal PLOS Biology by Daesung Shin of the University at Buffalo, U.S. and colleagues.

5 Jul 2022

Innovative strategy for treating non-small cell lung cancer when radiotherapy fails

Lung cancer is the most common cancer in the world, with 2.2 million new cases and around 1.8 million deaths in 2020 alone.

4 Jul 2022

New signaling molecule may offer a therapeutic treatment for common form of hair loss

University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

30 Jun 2022

Anticancer drug candidate that targets a human protein could be a pan-viral medication

More than two years into the COVID-19 pandemic, people are realizing that the "new normal" will probably involve learning to co-exist with SARS-CoV-2. Some treatments are available, but with new variants emerging, researchers are looking toward new strategies.

29 Jun 2022

Study reveals surprising reasons why cancer cells are often forced to rely on fat imports

Columbia and MIT researchers are revealing the surprising reasons why cancer cells are often forced to rely on fat imports, a finding that could lead to new ways to understand and slow down tumor growth.

27 Jun 2022

Rensselaer scientists secure $3.5 million grant to develop a low-dose, oral COVID antiviral drug

Rensselaer Polytechnic Institute researchers Gaetano Montelione and Christopher Cioffi will use a five-year, $3.5 million grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to develop a low-dose, oral COVID antiviral drug that can be administered at home.

27 Jun 2022

MD Anderson announces collaborative alliance with Turning Point Therapeutics to advance new treatment options for cancer patients

The University of Texas MD Anderson Cancer Center and Turning Point Therapeutics, Inc., today announced a strategic research and development alliance to expand the evaluation of two of Turning Point's investigational small molecules focusing on precision medicine targets well known in oncology.

24 Jun 2022

New molecular information could help develop more effective treatments for melanoma

A new study reveals important molecular information that could help scientists develop more effective treatment and prevention strategies for a difficult-to-treat form of melanoma skin cancer.

24 Jun 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

Erectile dysfunction drugs may be able to boost the effect of chemotherapy in esophageal cancer

A group of drugs commonly used to treat erectile dysfunction may be able to boost the effect of chemotherapy in esophageal cancer, according to new research funded by Cancer Research UK and the Medical Research Council.

21 Jun 2022

GPR183 gene a novel drug target for severe COVID-19

In a recent study posted to the bioRxiv* pre-print server, researchers provide the first preclinical evidence of the usefulness of antagonists of G-protein coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced gene 2 (EBI2), in reducing coronavirus disease 2019 (COVID-19) severity.

17 Jun 2022

Male gut health may benefit from beer

In a recent article published in the Journal of Agricultural and Food Chemistry, scientists analyzed the effect of alcoholic and nonalcoholic beer ingestion on gut microbiota.

17 Jun 2022

Genetic screening algorithm can estimate a person's risk of developing chronic kidney disease

A new algorithm developed by researchers at Columbia University can analyze thousands of variants across the genome and estimate a person's risk of developing chronic kidney disease - and it works in people of African, Asian, European, and LatinX descent.

16 Jun 2022

Researchers create first bona fide mouse model of Merkel cell carcinoma

A team of researchers at the University of Michigan Rogel Cancer Center were the first to generate a bona fide mouse model of a Merkel cell carcinoma, a rare and potentially aggressive form of skin cancer.

15 Jun 2022

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature.

15 Jun 2022

Preclinical News and Research

Researchers unravel mechanism that underlies failure of staph vaccine trials

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

Scientists discover a key starting point for inhibiting inflammation in psoriasis and psoriatic arthritis

Running faster and dreaming help your left brain and right brain to communicate better

Latest omicron subvariants are better at eluding vaccines and antibody treatments

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

Innovative strategy for treating non-small cell lung cancer when radiotherapy fails

New signaling molecule may offer a therapeutic treatment for common form of hair loss

Anticancer drug candidate that targets a human protein could be a pan-viral medication

Study reveals surprising reasons why cancer cells are often forced to rely on fat imports

Rensselaer scientists secure $3.5 million grant to develop a low-dose, oral COVID antiviral drug

MD Anderson announces collaborative alliance with Turning Point Therapeutics to advance new treatment options for cancer patients

New molecular information could help develop more effective treatments for melanoma

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Erectile dysfunction drugs may be able to boost the effect of chemotherapy in esophageal cancer

GPR183 gene a novel drug target for severe COVID-19

Male gut health may benefit from beer

Genetic screening algorithm can estimate a person's risk of developing chronic kidney disease

Researchers create first bona fide mouse model of Merkel cell carcinoma

Androgen receptor signaling affects response to targeted therapy in people with melanoma

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