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Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect how the brain functions.

2 Jul 2021

Mustard seed, wall rocket and turmeric extracts show potential against SARS-CoV-2 in vitro

Researchers in Spain have identified plant extracts that may be of interest in the search for treatments of coronavirus disease 2019 (COVID-19) and serve as a basis for future chemical, in vivo, and clinical trials.

1 Jul 2021

Developing AI technology to detect early signs of Alzheimer's disease

With the support of a new grant worth $3.9 million, Michigan State University researchers are developing technology that scans speech and vocabulary patterns to catch early signs of Alzheimer's disease, the most common cause of dementia.

1 Jul 2021

Reactive oxygen species are important components in cancer treatments

Reactive oxygen species (ROS) are highly reactive chemicals which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen and hydroxyl radicals are the major examples of ROS, which are familiar to persons from many walks of life as they are used in many domestic and industrial processes.

1 Jul 2021

First demonstration of COVID-19-like response by an essential virus encoded protein by SARS-CoV-2 in vivo

Researchers from collaborating universities in Virginia have recently utilized transgenic mice to explore the effects of SARS-CoV-2 on associated lung injury.

30 Jun 2021

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

In an effort to hasten the research on identifying antiviral drugs for SARS-CoV-2 infection, researchers from the U.S. and Switzerland performed extensive drug screening for antiviral activity using live virus infection in human respiratory cells. As a result, they identified a set of possible drug candidates that could potentially be tested in clinical trials.

30 Jun 2021

Researchers successfully implanted the first artificial tubular muscle in vivo

In January of this year, EPFL engineers announced in Advanced Science their concept of a novel cardiac assist device that is devoid of rigid metallic components. It consists of a soft, artificial muscle wrapped around the aorta that can constrict and dilate the vessel, ultimately enhancing the aorta's natural function and aiding the heart to pump blood to the rest of the body.

30 Jun 2021

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Skoltech researchers and their colleagues from Russia and the UK investigated the safety and efficacy of new chemistry in antisense oligonucleotides used to treat spinal muscular atrophy (SMA), a debilitating genetic disease.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

New technology can help improve various materials implanted into the human body

Medical materials that can be inserted into the human body have been used for decades in the field of regenerative medicine - for example, stents that can help dilate clogged blood vessels and implants that can replace teeth or bones.

25 Jun 2021

Study: Low Omega-3 Index is just as powerful in predicting early death as smoking

A new research paper published in the American Journal of Clinical Nutrition last week showed that a low Omega-3 Index is just as powerful in predicting early death as smoking. This landmark finding is rooted in data pulled and analyzed from the Framingham study, one of the longest running studies in the world.

25 Jun 2021

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

Researchers uncover new function of regulator protein in multiple myeloma development

A specific regulatory protein significantly influences the development of tumor-inducing blood vessels in the bone marrow of blood cancer patients.

24 Jun 2021

Study finds no evidence for remdesivir's benefit in severe COVID-19 patients

A new analysis of current data indicates that remdesivir does not show efficacy in regulating the severity of the illness.

23 Jun 2021

New coatings for titanium implants can fasten osseointegration

Researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) in collaboration with colleagues from St. Petersburg State University developed the coatings for titanium implants, which accelerate the implantation of the implant material into the bone tissue.

23 Jun 2021

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

A research collaboration based in Kumamoto University (Japan) has identified a novel lncRNA, Caren, that is abundantly expressed in cardiomyocytes.

23 Jun 2021

Protein found in cow’s milk could increase absorption of blueberries’ nutrients

Pairing blueberry pie with a scoop of ice cream is a nice summer treat. Aside from being tasty, this combination might also help people take up more of the "superfruit's" nutrients, such as anthocyanins.

23 Jun 2021

$New composite material could soon replace metal plates in treating difficult fractures$

New composite material could soon replace metal plates in treating difficult fractures

A new biocompatible polymer-based composite material could soon replace metal plates in treating difficult and unstable fractures.

23 Jun 2021

Natural compound myricetin shows antiviral potential against SARS-CoV-2

New findings from a team of Chinese researchers suggest natural compounds — specifically the flavonoid myricetin — could also be a potential drug candidate for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

23 Jun 2021

in vivo News and Research

Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Mustard seed, wall rocket and turmeric extracts show potential against SARS-CoV-2 in vitro

Developing AI technology to detect early signs of Alzheimer's disease

Reactive oxygen species are important components in cancer treatments

First demonstration of COVID-19-like response by an essential virus encoded protein by SARS-CoV-2 in vivo

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

Researchers successfully implanted the first artificial tubular muscle in vivo

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Nanotechnology and the fight against COVID-19

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

New technology can help improve various materials implanted into the human body

Study: Low Omega-3 Index is just as powerful in predicting early death as smoking

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

Researchers uncover new function of regulator protein in multiple myeloma development

Study finds no evidence for remdesivir's benefit in severe COVID-19 patients

New coatings for titanium implants can fasten osseointegration

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

Protein found in cow’s milk could increase absorption of blueberries’ nutrients

New composite material could soon replace metal plates in treating difficult fractures

Natural compound myricetin shows antiviral potential against SARS-CoV-2

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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