Cell Death News and Research

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UCLA scientists identify four subtypes of melanoma with different drug sensitivities

Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states - that is, to regress to an earlier stage of development - which can lead it to become resistant to treatment.

12 Apr 2018

Aberrant protein prevents self-cleaning of nerve cells in ALS

Scientists have discovered that TDP-43 interferes with lysosomal pathways responsible for its clearance and induces autophagy in ALS.

12 Apr 2018

Researchers explore treatment target for acute kidney injury

When you have diabetes then get an acute kidney injury there is a multiplier effect that can worsen your prognosis and destroy your kidneys.

10 Apr 2018

Finding new drug target for common form of lung cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer.

10 Apr 2018

Food packaging may have negative impact on nutrient absorption in the intestine

Food packaging could be negatively affecting the way in which your digestive tract operates, according to new research by faculty and students at Binghamton University, State University at New York.

9 Apr 2018

ALS and frontotemporal dementia share genetic connections

Nearly half of all patients with amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder, develop cognitive problems that affect memory and thinking.

9 Apr 2018

Resistance training enhances cellular recycling in muscle cells

A new study has shown that resistance training among previously untrained men increases autophagosome content, but that this effect may be blunted by aging.

9 Apr 2018

New PET imaging agent could help guide treatments for people with neurological diseases

Researchers have developed a new imaging agent that could help guide and assess treatments for people with various neurological diseases, including Alzheimer's, Parkinson's, and multiple sclerosis.

2 Apr 2018

Molecular inhibitors found to arrest tumor cell proliferation in lung cancer and mesothelioma

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis.

2 Apr 2018

Researchers develop novel approach to fighting ovarian cancer

Researchers have discovered a cellular pathway that selectively regulates a mutant protein linked to the growth of ovarian cancer.

29 Mar 2018

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, as a new therapeutic option for ovarian cancer with mutations in the ARID1A gene.

27 Mar 2018

Combination therapy effectively induces tumor cell death and reduces spread of breast cancer

Each day, normal human cell tissues express a protein known as p53 that wages war against potential malignancies. However, between 30 and 40 percent of human breast cancers express a defective (mutant) form of p53 that helps cancer cells proliferate and grow.

27 Mar 2018

Scientists discover new family of promising silver-based anti-cancer drugs

A new family of very promising silver-based anti-cancer drugs has been discovered by researchers in South Africa. The most promising silver thiocyanate phosphine complex among these, called UJ3 for short, has been successfully tested in rats and in human cancer cells in the laboratory.

26 Mar 2018

New study identifies key cellular mechanisms behind vascular aging in mice

We are as old as our arteries, the adage goes, so could reversing the aging of blood vessels hold the key to restoring youthful vitality? The answer appears to be yes, at least in mice, according to a new study led by investigators at Harvard Medical School.

22 Mar 2018

Newly designed three-part molecule shows promise to treat breast cancers

A newly designed three-part molecule could be the one answer patients with a certain form of breast cancer are looking for, scientists report.

22 Mar 2018

Targeting aberrantly active telomerase to treat therapy-resistant melanoma

A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.

21 Mar 2018

Research provides better understanding of how cancerous cells behave in low oxygen

An international team of researchers found how cancer cells respond to DNA damage signaling when in low oxygen, or hypoxia.

21 Mar 2018

NIH researchers explore genetic clocks to understand role of aging in neurodegeneration

To understand the link between aging and neurodegenerative disorders such as Alzheimer's disease, NIH scientists compared the genetic clocks that tick during the lives of normal and mutant flies.

14 Mar 2018

New class of antimicrobial polymers can kill five hard-to-treat multidrug-resistant bacteria

An international research team led by the Institute of Bioengineering and Nanotechnology of the Agency for Science, Technology and Research and IBM Research developed a synthetic molecule that can kill five deadly types of multidrug-resistant bacteria with limited, if any, side effects.

7 Mar 2018

Study findings establish basis for epigenetic link between aging and Alzheimer's disease

Although certain genetic variants increase the risk of Alzheimer's disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery.

6 Mar 2018

Cell Death News and Research

UCLA scientists identify four subtypes of melanoma with different drug sensitivities

Aberrant protein prevents self-cleaning of nerve cells in ALS

Researchers explore treatment target for acute kidney injury

Finding new drug target for common form of lung cancer

Food packaging may have negative impact on nutrient absorption in the intestine

ALS and frontotemporal dementia share genetic connections

Resistance training enhances cellular recycling in muscle cells

New PET imaging agent could help guide treatments for people with neurological diseases

Molecular inhibitors found to arrest tumor cell proliferation in lung cancer and mesothelioma

Researchers develop novel approach to fighting ovarian cancer

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Combination therapy effectively induces tumor cell death and reduces spread of breast cancer

Scientists discover new family of promising silver-based anti-cancer drugs

New study identifies key cellular mechanisms behind vascular aging in mice

Newly designed three-part molecule shows promise to treat breast cancers

Targeting aberrantly active telomerase to treat therapy-resistant melanoma

Research provides better understanding of how cancerous cells behave in low oxygen

NIH researchers explore genetic clocks to understand role of aging in neurodegeneration

New class of antimicrobial polymers can kill five hard-to-treat multidrug-resistant bacteria

Study findings establish basis for epigenetic link between aging and Alzheimer's disease

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics