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Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

A new paper discusses the appearance of quasi-species in a single host with prolonged infection, with different rates of infectivity and sensitivity to neutralization by antibodies elicited by the Pfizer vaccine or those present in convalescent plasma.

17 Jan 2022

Discovery opens up the possibility of pursuing new therapies for FOP

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by extensive bone growth outside of the normal skeleton that pre-empts the body's normal responses to even minor injuries. It results in what some term a "second skeleton," which locks up joint movement and could make it hard to breathe.

16 Jan 2022

Mutations in SARS-CoV-2 Omicron variant promote cell binding

Researchers in Germany, based on their recent study published in the journal ChemBioChem, have proposed that the elevated occurrence of positively charged amino acids in specific domains of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) Omicron variant spike protein improves viral binding to cellular negatively charged receptors aiding in enhanced infectiousness.

16 Jan 2022

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

A new study published in the Centers for Disease Control and Prevention’s Emerging Infectious Diseases journal has hypothesized that locations with positive SARS-CoV-2 in sewage could be used as potential surveillance targets to analyze if pestiferous urban rodents shed SARS-CoV-2 into the environment.

16 Jan 2022

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

New research suggests that the SARS-CoV-2 Omicron spike protein requires significantly higher levels of ACE2 for efficient membrane fusion, lagging behind other variants.

14 Jan 2022

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

A new study, posted to the bioRxiv* preprint server, has developed a single-cell atlas that presents the shared and distinct immune responses and metabolism following SARS-CoV-2 and HIV-1 infections.

13 Jan 2022

Virus-like particles as delivery vehicles for gene-editing

Scientists deliver gene-editing proteins through the use of engineered virus-like particles, which mediated efficient base editing both in vitro and in vivo.

13 Jan 2022

Defective gene in blood cancers could be treated with already available drugs

A defective gene, normally found in blood cancers, could be treated with drugs already available for cancers with similar gene defects, scientists at Queen’s University Belfast and the University of Birmingham have revealed.

13 Jan 2022

Forecasting seasonal SARS-CoV-2 mutations

In a study published in Science Translational Medicine, researchers have been trying to create a technique to predict which of these mutations will spread.

13 Jan 2022

COVID-19 infection sera analysis against varying antigens of SARS-CoV-2 variants

In a new study, researchers assessed the sera from COVID-19 infected and vaccinated individuals against the receptor-binding domain in the spike protein of the SARS-CoV-2 wildtype virus and its variants.

13 Jan 2022

Ultra-rapid genome sequencing technology can detect rare genetic diseases in eight hours

A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators was used to diagnose rare genetic diseases in an average of eight hours - a feat that's nearly unheard of in standard clinical care.

13 Jan 2022

The Native Antigen Company Expands Range of Norovirus-Like Particles

The Native Antigen Company today announced the expansion of its norovirus-like particle range, with the addition of six new reagents.

From The Native Antigen Company 13 Jan 2022

New method for monitoring circulating SARS-CoV-2 variants and detecting new ones

To understand and act early and appropriately to emerging variants of concern, researchers have explored the possibility of having a variant-agnostic detection assay.

12 Jan 2022

Engineering higher affinity SARS-CoV-2 antibodies

A new study describes the potential of engineered neutralizing antibodies that have a high affinity for the binding epitopes.

11 Jan 2022

Study opens up prospects for using virotherapy to treat central nervous system tumors

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

11 Jan 2022

Mutation News and Research

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

Discovery opens up the possibility of pursuing new therapies for FOP

Mutations in SARS-CoV-2 Omicron variant promote cell binding

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

Virus-like particles as delivery vehicles for gene-editing

Defective gene in blood cancers could be treated with already available drugs

Forecasting seasonal SARS-CoV-2 mutations

COVID-19 infection sera analysis against varying antigens of SARS-CoV-2 variants

Ultra-rapid genome sequencing technology can detect rare genetic diseases in eight hours

The Native Antigen Company Expands Range of Norovirus-Like Particles

New method for monitoring circulating SARS-CoV-2 variants and detecting new ones

Engineering higher affinity SARS-CoV-2 antibodies

Study opens up prospects for using virotherapy to treat central nervous system tumors

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

First patient-derived stem cell model developed for studying oculocutaneous albinism

VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring

Developing a 'fingerprint' test that could diagnose Alzheimer’s early

Study finds T cell response mostly conserved against SARS-CoV-2 Omicron variant following infection or vaccination

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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