Preclinical News and Research

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Synexa Life Sciences Opens New Rockville Laboratory Site in North America

Synexa Life Sciences recently opened new lab facilities in Rockville, Maryland (US) to work closely with US clients and provide a more extensive range of solutions, including Synexa’s industry-leading specialist flow cytometry services.

From Synexa Life Sciences 15 Jun 2022

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

A team of researchers led by Dr. Sandra Castillo and Dr. Mariona Graupera, from the Josep Carreras Leukaemia Research Institute and member of the CIBERONC, have found the AKT inhibitor miransertib could be a new molecular treatment effective against low-flow vascular malformations, a long-awaited milestone.

14 Jun 2022

Uncontrolled diabetes can increase the risk of heart failure progression, study finds

Among older adults with early stage - also known as preclinical - heart failure, uncontrolled diabetes can substantially increase the risk of heart failure progression, according to a new Johns Hopkins-led study.

14 Jun 2022

New research in mice investigates the safety of DNA nanotechnology

Advances in nanotechnology have made it possible to fabricate structures out of DNA for use in biomedical applications like delivering drugs or creating vaccines, but new research in mice investigates the safety of the technology.

14 Jun 2022

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

Probiotic bacteria may enhance anti-cancer activities of the breast cancer drug tamoxifen and other endocrine-targeted therapies, which could help reduce the risk of estrogen receptive positive (ER+) breast cancer, suggests a new study presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Inhaled vaccines provide better protection and stronger immunity than nasal sprays, study confirms

McMaster University scientists who compared respiratory vaccine-delivery systems have confirmed that inhaled aerosol vaccines provide far better protection and stronger immunity than nasal sprays.

10 Jun 2022

Using artificial intelligence to discover new antivirals against COVID-19 and future pandemics

Research into drugs to treat mosquito-borne flaviviruses such as Zika and dengue as well as COVID-19will benefit from a major funding boost, says a group of international scientists using artificial intelligence to discover new oral antivirals.

10 Jun 2022

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Researchers have known for some time that maternal breast milk provides critical nutrients for newborns, and antibodies from mothers vaccinated against a specific disease-causing bacterium or virus can be transferred via breast milk to babies.

10 Jun 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

New hot-melt tissue adhesive can heal operative wounds

NIMS has developed a hot-melt tissue adhesive (i.e., medical glue that is applied in a molten state) capable of healing operative wounds.

9 Jun 2022

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of its genetic material: the messenger RNA.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

Immune protein could be a target of future treatments for alcohol use disorder

The anxiety that occurs during withdrawal from excessive alcohol use, and contributes to relapse, may be driven in part by the release of an immune protein in the brain, according to a new study from scientists at Scripps Research.

8 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022

Chemo-immunotherapy combination shows promise against pancreatic cancer

A combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system was effective against one of the hardest targets in cancer care, pancreatic cancer, in a national, randomized clinical trial led by researchers at the Perelman School of Medicine at the University of Pennsylvania, and sponsored by the Parker Institute for Cancer Immunotherapy.

6 Jun 2022

Biodegradable piezoelectric film could help regenerate the native cartilage after knee damage

Osteoarthritis – a painful condition that results from the deterioration of the cartilage in our joints – affects millions of people worldwide.

3 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

MD Anderson and National Resilience launch the Cell Therapy Manufacturing Center

The University of Texas MD Anderson Cancer Center and National Resilience, Inc., today announced the launch of a joint venture, the Cell Therapy Manufacturing Center, to accelerate the development and manufacturing of innovative cell therapies for patients with cancer.

2 Jun 2022

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

To image microscopic vessels and measure blood flow in the brain, researchers use a tool called ultrasound localization microscopy. It works by using microscopic bubbles circulated through the bloodstream as a contrast agent to measure the reflection of high-frequency acoustic waves passing through the body.

1 Jun 2022

Genetically modified herpes virus can be used in the fight against cancer

Viruses can make animals and humans sick - or healthy: Researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB have succeeded in genetically modifying the herpes simplex virus type 1, which triggers painful cold sores, in such a way that it can be used in the fight against cancer in the future.

1 Jun 2022

Preclinical News and Research

Synexa Life Sciences Opens New Rockville Laboratory Site in North America

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

Uncontrolled diabetes can increase the risk of heart failure progression, study finds

New research in mice investigates the safety of DNA nanotechnology

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

Inhaled vaccines provide better protection and stronger immunity than nasal sprays, study confirms

Using artificial intelligence to discover new antivirals against COVID-19 and future pandemics

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

New hot-melt tissue adhesive can heal operative wounds

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Immune protein could be a target of future treatments for alcohol use disorder

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Chemo-immunotherapy combination shows promise against pancreatic cancer

Biodegradable piezoelectric film could help regenerate the native cartilage after knee damage

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

MD Anderson and National Resilience launch the Cell Therapy Manufacturing Center

Ultrasound localization microscopy can image microscopic vessels and measure blood flow in the brain

Genetically modified herpes virus can be used in the fight against cancer

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