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Researchers suggest that visible blue light is a safe and variant-agnostic therapy against SARS-CoV-2

In a new study, researchers showed that 425 nm blue light can inactivate all major SARS CoV 2 variants.

4 Feb 2022

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Researchers evaluate how the D614G and P681H mutations alter the attributes of SARS-CoV-2 VOCs.

3 Feb 2022

Global efforts to track COVID-19 variants grossly underreported a probable variant of concern in Nigeria

If the United States ignores COVID-19 in Nigeria, we forgo global genomic surveillance at our own peril, reports a new Northwestern Medicine study published in Nature Communications.

3 Feb 2022

Study describes the first three days of SARS-CoV-2 infection in an ALI model of proximal airway epithelium

Researchers evaluated the initial three days of SARS-CoV-2 infection via scRNAseq dataset in humanized in vitro model.

3 Feb 2022

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Researchers demonstrate that SARS-CoV-2 RBD-based nanoparticle vaccine induces neutralizing antibodies against SARS-CoV-2 variants.

2 Feb 2022

Researchers elucidate first 3D structure of regulator protein complex

Proteins are indispensable components in living organisms. They are not only "building material" for the body – they also make molecular communication between cells possible, they are needed for nerve impulses to occur, and they control chemical reactions.

2 Feb 2022

Novel approach to improve intranasal sprays used to treat respiratory viral infections

Researchers proposed a novel approach to improve intranasal sprays used to treat respiratory viral infections, including SARS-CoV-2 infections.

2 Feb 2022

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.

2 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

Developing post-vaccination SARS-CoV-2 standard reference sera

A new study reports the generation of reference sera reagents that were obtained from subjects vaccinated with one of four COVID-19 vaccines.

1 Feb 2022

Researchers generate a complex kidney-like 3D tissue in the lab

A research team based in Kumamoto University (Japan) has created complex 3D kidney tissue in the lab solely from cultured mouse embryonic stem (ES) cells.

1 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

in vitro News and Research

Researchers suggest that visible blue light is a safe and variant-agnostic therapy against SARS-CoV-2

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Global efforts to track COVID-19 variants grossly underreported a probable variant of concern in Nigeria

Study describes the first three days of SARS-CoV-2 infection in an ALI model of proximal airway epithelium

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Researchers elucidate first 3D structure of regulator protein complex

Novel approach to improve intranasal sprays used to treat respiratory viral infections

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Nanomedicine can be improved with proper and more predictive in vitro assays

Developing post-vaccination SARS-CoV-2 standard reference sera

Researchers generate a complex kidney-like 3D tissue in the lab

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

Study identifies drugs that could help combat mortality in patients with COVID-19

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

It’s Day 6 of covid, and a rapid antigen test comes back positive. stay home, say virologists.

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Driving innovation in drug discovery with in vitro biology solutions eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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