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FDA approves Vaxchora for prevention of cholera

The U.S. Food and Drug Administration today approved Vaxchora, a vaccine for the prevention of cholera caused by serogroup O1 in adults 18 through 64 years of age traveling to cholera-affected areas. Vaxchora is the only FDA-approved vaccine for the prevention of cholera.

13 Jun 2016

Findings may help explain why rheumatoid arthritis drugs vary in effect

Researchers at the University of California San Diego School of Medicine, with colleagues in Pennsylvania and China, report that not only are there distinct differences in key cellular processes and molecular signatures between rheumatoid arthritis (RA) and osteoarthritis (OA) but, more surprisingly, there are joint-specific differences in RA.

12 Jun 2016

Individual patient meta-analysis supports tPA stroke benefits

The benefits of intravenous tissue plasminogen activator outweigh the risks in acute stroke patients treated within 4.5 hours of symptom onset, reports the Stroke Thrombolysis Trialists' Collaboration.

12 Jun 2016

Immunoablation strengthens haemopoietic stem-cell transplantation effects in MS

Intensifying current transplant conditioning to remove rather than suppress immune cells ahead of autologous haematopoietic stem cell transplantation may result in long-term remission of multiple sclerosis, phase II trial findings show.

10 Jun 2016

Study captures interactions of HIV-infected immune cells in living animal

By watching brightly glowing HIV-infected immune cells move within mice, researchers at the Icahn School of Medicine at Mount Sinai have shown how infected immune cells latch onto an uninfected sister cell to directly transmit newly minted viral particles.

10 Jun 2016

Utah researchers find way to use power of protease to destroy budding AIDS virus

When new AIDS virus particles bud from an infected cell, an enzyme named protease activates to help the viruses mature and infect more cells. That's why modern AIDS drugs control the disease by inhibiting protease.

10 Jun 2016

FDA takes action against websites that illegally sell unapproved prescription drugs

The U.S. Food and Drug Administration, in partnership with international regulatory and law enforcement agencies, announced that it took action this week against 4,402 websites that illegally sell potentially dangerous, unapproved prescription drugs to U.S. consumers.

10 Jun 2016

Women with SLE may have increased cervical cancer risk

The results of a study presented today at the European League Against Rheumatism Annual Congress found a doubled risk of pre-malignant cervical changes, and potentially also an increased risk of cervical cancer, among women with Systemic Lupus Erythematosus (SLE) compared to the general female population.

10 Jun 2016

Tackling Healthcare Challenges in a Changing World: an Interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome.

10 Jun 2016

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

The results of a study presented today at the European League Against Rheumatism Annual Congress showed that tiny particles made of a biodegradable polymer (BNPs -- biodegradable polymer nanoparticles) have the potential to enable early detection and efficient long-term treatment of rheumatoid arthritis (RA), with minimal side effects.

10 Jun 2016

Type 1 diabetes occurs more frequently in patients with JIA

The results of a study involving more than 9,000 patients, presented today at the European League Against Rheumatism Annual Congress showed that Type 1 diabetes occurs significantly more frequently in patients with Juvenile Inflammatory Arthritis (JIA) than in the general population.

10 Jun 2016

Anti-CPP presence in bloodstream of RA patients correlates with drug response

The results of a study presented today at the European League Against Rheumatism Annual Congress showed that the presence of an antibody (anti-CPP ) in the bloodstream of patients with rheumatoid arthritis (RA) correlates with response to different drug treatments.

10 Jun 2016

Antibody-positive patients treated with infliximab less likely to benefit from infliximab biosimilar

The results of a study presented today at the European League Against Rheumatism Annual Congress showed that when antibodies develop in response to the biological treatment Remicade (infliximab), they also cross-react with the biosimilar of infliximab (CT-P13: Inflectra or Remsima).

10 Jun 2016

Avoiding allergens could be best approach to prevent food allergies

Around two million people in Austria suffer from an allergy. 400,000 of them are allergic to birch pollen and have associated food allergies, particularly to apples, peaches, hazelnuts, carrots and celery. According to experts, around 80,000 people are thought to have a primary food allergy in childhood.

9 Jun 2016

Study finds positive support from all racial/ethnic groups for physician-assisted death

Physician-assisted death was supported by a majority of California and Hawaii residents, regardless of their ethnicity, who responded to an online survey, according to a study by researchers at the Stanford University School of Medicine.

9 Jun 2016

Scientists resuscitate efforts to crack KRas protein structures

In the annals of cancer research, a protein known as KRas has become notorious. Part of a family of proteins implicated in 30 percent of cancers, KRas is considered a highly desirable but defiant drug target.

9 Jun 2016

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

9 Jun 2016

Childhood psychological trauma can increase likelihood of drug misuse in adolescence

Latest research from a national sample of almost 10,000 U.S. adolescents found psychological trauma, especially abuse and domestic violence before age 11, can increase the likelihood of experimentation with drugs in adolescence, independent of a history of mental illness.

9 Jun 2016

New drug for chronic migraine may reduce headache hours in few days

A new drug to prevent migraine was associated with fewer headache hours for people with chronic migraine within three to seven days after the first injection, according to a study published in the June 8, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology.

9 Jun 2016

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

A multi-center team of researchers in the U.S. testing the potential of cell therapy for treating Parkinson's disease (PD) has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human primates modeled with PD promoted behavioral recovery, increased dopamine concentrations in the brain, and induced the expression of beneficial genes and pathways when compared to control animals not transplanted with stem cells.

9 Jun 2016

Drugs News and Research

FDA approves Vaxchora for prevention of cholera

Findings may help explain why rheumatoid arthritis drugs vary in effect

Individual patient meta-analysis supports tPA stroke benefits

Immunoablation strengthens haemopoietic stem-cell transplantation effects in MS

Study captures interactions of HIV-infected immune cells in living animal

Utah researchers find way to use power of protease to destroy budding AIDS virus

FDA takes action against websites that illegally sell unapproved prescription drugs

Women with SLE may have increased cervical cancer risk

Tackling Healthcare Challenges in a Changing World: an Interview with Professor Jeremy Nicholson

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

Type 1 diabetes occurs more frequently in patients with JIA

Anti-CPP presence in bloodstream of RA patients correlates with drug response

Antibody-positive patients treated with infliximab less likely to benefit from infliximab biosimilar

Avoiding allergens could be best approach to prevent food allergies

Study finds positive support from all racial/ethnic groups for physician-assisted death

Scientists resuscitate efforts to crack KRas protein structures

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

Childhood psychological trauma can increase likelihood of drug misuse in adolescence

New drug for chronic migraine may reduce headache hours in few days

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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