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$ART trial: Adacolumn shows clinical benefit in refractory ulcerative colitis patients$

ART trial: Adacolumn shows clinical benefit in refractory ulcerative colitis patients

Data from the 48-week ART trial, presented today at the Digestive Disease Week meeting, showed that remission and response rates were 37.2% and 53.2% respectively at week 12, in patients with moderate-to-severe, steroid-dependent active ulcerative colitis (UC) with insufficient response or intolerance to immunosuppressants and / or biologics when treated with between five and eight sessions with Adacolumn.

26 May 2016

TSRI scientists discover new method for harnessing venoms for therapeutic use

There are lessons to be learned from venoms. Scorpions, snakes, snails, frogs and other creatures are thought to produce tens or even hundreds of millions of distinct venoms. These venoms have been honed to strike specific targets in the body.

26 May 2016

Combining sonoporation with chemotherapy drug may help improve pancreatic cancer treatment

Researchers at Haukeland University Hospital in Bergen, Norway have combined a laboratory ultrasound technique called "sonoporation" with the commercially-available chemotherapy compound Gemcitabine to increase the porosity of pancreatic cells with microbubbles and to help get the drug into cancer cells where it is needed.

26 May 2016

SBP scientists discover new regulator of immune responses

Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a new regulator of immune responses. The study, published recently in Immunity, sheds new light on why T cells fail to clear chronic infections and eliminate tumors.

26 May 2016

Common pain and anti-inflammation drugs may slow cancer growth

Scientists from the Florida campus of The Scripps Research Institute have found that one of the most widely prescribed pain and anti-inflammation drugs slows the growth rate of a specific kind of cancer in animal models and suggests the medication could have the same effect on other types of tumors.

26 May 2016

Researchers discover how specific gene inhibits bacterial invasion of colonic epithelia

A group of researchers at Osaka University elucidated how a gene named Ly6/Plaur domain containing 8 (Lypd8) inhibits bacterial invasion of colonic epithelia, regulating intestinal inflammation. This achievement may lead to the development of drugs for ulcerative colitis.

25 May 2016

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Clinical trials of the anti-cancer agent PAC-1 are continuing to expand, thanks to a $7 million angel investment from an anonymous contributor who originally invested $4 million to help get the compound this far in the drug-approval pipeline.

25 May 2016

Depressive symptoms may affect fertility of women

Women with severe depressive symptoms have a decreased chance of becoming pregnant, while the use of psychotropic medications does not appear to harm fertility, a study by researchers from the Boston University Schools of Public Health and Medicine shows.

25 May 2016

Multimodal therapy may improve survival of pancreatic cancer patients

In roughly one-third of pancreatic cancer patients, tumors have grown around the pancreas to encompass critical blood vessels. Conventional wisdom has long held that surgery to remove the tumors is rarely an option, and life expectancies are usually measured in months.

25 May 2016

Marijuana use among teens declines despite widespread legalization

A survey of more than 216,000 adolescents from all 50 states indicates the number of teens with marijuana-related problems is declining. Similarly, the rates of marijuana use by young people are falling despite the fact more U.S. states are legalizing or decriminalizing marijuana use and the number of adults using the drug has increased.

25 May 2016

Mitoxantrone for MS linked to colorectal cancer risk

Treatment with mitoxantrone for multiple sclerosis carries only a mildly increased risk of malignancy overall, but the risk of colorectal cancer and leukaemia is heightened, researchers have found.

24 May 2016

Single enzyme doing the work of a trio could offer precise way to treat diseases

Researchers identified a single enzyme doing the work of a trio thought necessary to control a common cellular signaling process being pursued as a therapeutic target.

24 May 2016

Early epigenetic changes could open way for new preventative strategies for ovarian cancer

Research revealing early changes at epigenetic level points to possible new prevention strategies for ovarian cancer. The discovery of early changes in the cells of the Fallopian tubes of women carrying the BRCA genetic mutation could open the way for new preventative strategies for ovarian cancer, reducing the need for invasive surgery, according to research published today in science journal Nature Communications.

24 May 2016

ANK3 and other genes may play key role in affecting mood, stress and longevity

The visible impacts of depression and stress that can be seen in a person's face -- and contribute to shorter lives -- can also be found in alterations in genetic activity, according to newly published research.

24 May 2016

Study explores incidence of heart failure following myocardial infarction

One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.

24 May 2016

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.

24 May 2016

Physical exercise may be as effective as drugs for treating prostate cancer patients

At age 70, Alfred Roberts plays hockey twice a week. Nothing special, right? Except that for three years he has had advanced prostate cancer, which has spread to his bones. "I've always been active. Hockey keeps me in shape and keeps my mind off things. I've got friends that have played until age 80, and my goal is to beat them!" said the veteran stick handler.

24 May 2016

Understanding structure of HIV-1 protease vital to development of next-generation HIV drugs

HIV, the virus that causes AIDS, has become one of the world’s most serious health and development challenges.

24 May 2016

Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Only 12% of kidney cancer patients with advanced disease survive five years after their initial treatment. In a Roswell Park Cancer Institute-led study, scientists report that some patients with advanced kidney cancer who continued to receive a novel immunotherapy drug after their disease progressed saw clinical benefit.

24 May 2016

Aliskiren fails to show benefit for heart failure patients with diabetes

A subgroup analysis in heart failure patients with diabetes from the ATMOSPHERE trial has failed to show benefit and signals the end of the road for aliskiren in heart failure.

24 May 2016

Drugs News and Research

ART trial: Adacolumn shows clinical benefit in refractory ulcerative colitis patients

TSRI scientists discover new method for harnessing venoms for therapeutic use

Combining sonoporation with chemotherapy drug may help improve pancreatic cancer treatment

SBP scientists discover new regulator of immune responses

Common pain and anti-inflammation drugs may slow cancer growth

Researchers discover how specific gene inhibits bacterial invasion of colonic epithelia

Clinical trials of anti-cancer agent PAC-1 continue to progress with anonymous funding

Depressive symptoms may affect fertility of women

Multimodal therapy may improve survival of pancreatic cancer patients

Marijuana use among teens declines despite widespread legalization

Mitoxantrone for MS linked to colorectal cancer risk

Single enzyme doing the work of a trio could offer precise way to treat diseases

Early epigenetic changes could open way for new preventative strategies for ovarian cancer

ANK3 and other genes may play key role in affecting mood, stress and longevity

Study explores incidence of heart failure following myocardial infarction

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

Physical exercise may be as effective as drugs for treating prostate cancer patients

Understanding structure of HIV-1 protease vital to development of next-generation HIV drugs

Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Aliskiren fails to show benefit for heart failure patients with diabetes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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