Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Stem cell transplantation improves outcomes in children with rare form of chronic blood cancer

Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children's Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

24 Jul 2015

Genetic variation influences survival in patients with multiple myeloma

As part of a multi-institutional effort, researchers with Huntsman Cancer Institute at the University of Utah have found that multiple myeloma patients with a genetic variation in the gene FOPNL die on average 1-3 years sooner than patients without it.

23 Jul 2015

New TCR therapy demonstrates encouraging clinical responses in patients with multiple myeloma

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

22 Jul 2015

Patients' own genetically engineered immune cells show significant success against multiple myeloma

In recent years, immunotherapy has emerged as a promising treatment for certain cancers. Now this strategy, which uses patients' own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.

21 Jul 2015

Proteins responsible for controlling iron levels in the body also fight against infection

Proteins responsible for controlling levels of iron in the body also play an important role in combatting infection, according to a study published today in Cell Host & Microbe.

17 Jul 2015

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to ageing been confirmed; defective telomeres seem to be linked to more and more illnesses, including many types of cancer.

16 Jul 2015

Emory University immunologists identify long-lived antibody-producing cells in bone marrow

Immunologists from Emory University have identified a distinct set of long-lived antibody-producing cells in the human bone marrow that function as an immune archive.

16 Jul 2015

Wayne State researcher receives $1.9 million grant to improve EPCs-based cell therapy for vascular diseases

Chunying Li, Ph.D., assistant professor in the Wayne State University School of Medicine's Department of Biochemistry and Molecular Biology, has secured his first R01 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to study the role and mechanism of the chemokine receptor CXCR2 in regulating new blood vessel formation, the so-called angiogenesis.

15 Jul 2015

IU researcher plays role in recent FDA approval of Neupogen drug to treat people exposed to radiation

An Indiana University Melvin and Bren Simon Cancer Center researcher played a role in the recent Food and Drug Administration approval of a drug to treat people exposed to potentially lethal doses of radiation.

15 Jul 2015

Transplanted MSCs slow progression of lupus nephritis by suppressing Tfh cells in SLE animal model

Systemic lupus erythematosus (SLE) is an autoimmune disease that produces autoantibodies and subsequent immune reactions that can lead to a variety of symptoms, including inflammation of the kidneys, or nephritis. When researchers transplanted mesenchymal stem cells (MSCs) derived from human bone marrow into mice modeled with SLE, they found that inflammation was reduced and nephritis "attenuated."

15 Jul 2015

Study shows possibility of using embryonic stem cells to repair damaged lung tissue

Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death worldwide. More than 35 million Americans alone suffer from chronic respiratory disease. Weizmann Institute scientists have now proposed a new direction that could, in the future, lead to the development of a method for alleviating some of their suffering.

15 Jul 2015

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Melbourne researchers have identified a protein responsible for preserving the antibody-producing cells that lead to long-term immunity after infection or vaccination.

14 Jul 2015

Acceleration of cell cycle transition kinetic can make human blood stem cells more powerful

For the first time, the research group of Prof. Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic impact on the fitness of human blood stem cells.

13 Jul 2015

Scientists uncover new genes that affect development and maintenance of blood stem cell

Even though the transplantation of blood stem cells, also known as bone marrow, has saved many lives over many decades, the genes that control the number or function of blood stem cells are not fully understood. In a study published in June in Stem Cell Reports, the USC Stem Cell labs of Hooman Allayee and Gregor Adams uncovered new genes that affect blood stem cell development and maintenance.

12 Jul 2015

IMBRUVICA (ibrutinib) approved in Europe for treatment of Waldenstrom's macroglobulinemia

Today AbbVie announced the European Commission granted marketing authorization for IMBRUVICA (ibrutinib) as the first treatment option available in all 28 member states of the European Union for the treatment of Waldenstrom's macroglobulinemia (WM), a rare, slow growing blood cancer, in adult patients who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy.

12 Jul 2015

Potential molecular link identified between excess fat in the blood and blood vessel recovery in ischemia

The buildup of fat in the blood makes a bad situation worse - it not only raises a person's risk for heart attack or stroke but also impairs the growth of new blood vessels. How excess fat in the blood - a condition known as hyperlipidemia - blocks vessel growth was unclear, but new work by researchers at Temple University School of Medicine shows that a molecule known as caspase-1 plays a central role and that preventing its activity could be the key to building new blood vessels and restoring blood supply to oxygen-starved tissues.

10 Jul 2015

City of Hope offers islet cell transplant program to cure type 1 diabetes

For patients with severe type 1 diabetes, a strict diet and insulin shots are sometimes not enough to sufficiently control their disease. What they need are insulin-producing cells of their own - currently only available through a still-experimental procedure known as islet cell transplantation.

8 Jul 2015

Cedars-Sinai researchers test new methods for preserving cognition in laboratory mice

Cedars-Sinai researchers have successfully tested two new methods for preserving cognition in laboratory mice that exhibit features of Alzheimer's disease by using white blood cells from bone marrow and a drug for multiple sclerosis to control immune response in the brain.

8 Jul 2015

City of Hope researchers to use patients' own modified T cells to treat advanced brain tumors

Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine's biggest challenges: brain cancer. This month, they will launch a clinical trial using patients' own modified T cells to fight advanced brain tumors.

7 Jul 2015

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Investigators have discovered the precise molecular steps that enable immune cells implicated in certain forms of asthma and allergy to develop and survive in the body. The findings from Weill Cornell Medical College reveal a new pathway that scientists could use to develop more effective treatments and therapies for the chronic lung disorder.

7 Jul 2015

Bone Marrow News and Research

Further Reading

Stem cell transplantation improves outcomes in children with rare form of chronic blood cancer

Genetic variation influences survival in patients with multiple myeloma

New TCR therapy demonstrates encouraging clinical responses in patients with multiple myeloma

Patients' own genetically engineered immune cells show significant success against multiple myeloma

Proteins responsible for controlling iron levels in the body also fight against infection

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Emory University immunologists identify long-lived antibody-producing cells in bone marrow

Wayne State researcher receives $1.9 million grant to improve EPCs-based cell therapy for vascular diseases

IU researcher plays role in recent FDA approval of Neupogen drug to treat people exposed to radiation

Transplanted MSCs slow progression of lupus nephritis by suppressing Tfh cells in SLE animal model

Study shows possibility of using embryonic stem cells to repair damaged lung tissue

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Acceleration of cell cycle transition kinetic can make human blood stem cells more powerful

Scientists uncover new genes that affect development and maintenance of blood stem cell

IMBRUVICA (ibrutinib) approved in Europe for treatment of Waldenstrom's macroglobulinemia

Potential molecular link identified between excess fat in the blood and blood vessel recovery in ischemia

City of Hope offers islet cell transplant program to cure type 1 diabetes

Cedars-Sinai researchers test new methods for preserving cognition in laboratory mice

City of Hope researchers to use patients' own modified T cells to treat advanced brain tumors

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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