Central Nervous System News and Research

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Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Cancer immunology is based upon boosting the body's own immune system to vanquish malignancies. It is among the fastest growing areas of oncology research. Researchers at UC San Diego Moores Cancer Center have launched three clinical trials to test the safety and efficacy of a novel cellular-immunotherapy that uses modified T cells - one of the immune system's primary weapons - to treat three different types of blood cancer that often defy existing therapies.

24 Feb 2016

Gamma Knife and RapidArc equally effective at eradicating cancer in the brain

While two advanced radiosurgery approaches — Gamma Knife and RapidArc — offer different strengths, they are equally effective at eradicating cancer in the brain, say researchers at Sidney Kimmel Cancer Center.

24 Feb 2016

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

Researchers at the Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona (IBB-UAB), in collaboration with the biopharmaceutical company SOM Biotech, located in the Barcelona Science Park (PCB), have published, in Nature Communications, the results of a drug repositioning study in which they describe a powerful drug, SOM0226 (tolcapone) that could significantly improve the pharmacological treatment of familial transthyretin amyloidosis (ATTR).

24 Feb 2016

Longer, more intense period of rehabilitation may boost recovery after stroke or traumatic injury

Cognitive and functional recovery after a stroke or traumatic injury requires intense rehabilitative therapy to help the brain repair and restructure itself. New findings by researchers at University of California, San Diego School of Medicine report that not only is rehabilitation vital - in an animal model, rats with cortical injury that did not receive intensive rehab did not rebuild brain structure or recover function - but that a longer, even more intense period of rehabilitation may produce even greater benefit.

23 Feb 2016

New CODMAN ENTERPRISE 2 Vascular Reconstruction Device launched for treatment of intracranial aneurysms

Codman Neuro has launched the CODMAN ENTERPRISE 2 Vascular Reconstruction Device, the latest generation of the company’s self-expanding stent and delivery system used to treat wide-necked intracranial aneurysms and to help maintain the position of endovascular coils during and after the procedure.

23 Feb 2016

UCLA-led researchers identify specific gene network that promotes repair in peripheral nervous system

Whether or not nerve cells are able to regrow after injury depends on their location in the body. Injured nerve cells in the peripheral nervous system, such as those in the arms and legs, can recover and regrow, at least to some extent. But nerve cells in the central nervous system -- the brain and spinal cord -- can't recover at all.

22 Feb 2016

Wearable robotic exoskeleton may enable multiple sclerosis patients to walk more efficiently

Walking with a wearable robotic exoskeleton may enable people with multiple sclerosis to walk more efficiently by reducing the energy and muscle activity needed to walk, according to research presented this week at the Association for Academic Physiatrists Annual Meeting in Sacramento, Calif.

19 Feb 2016

Study provides new insights into Retigabine drug

A study published ahead of print in the The Journal of General Physiology has revealed new insights into Retigabine, a known pharmacological treatment for epilepsy.

19 Feb 2016

Commonly used chemo toxins damage eyesight in childhood cancer survivors

A study from Lund University in Sweden shows that commonly used chemo toxins impair the eyesight in childhood cancer survivors in a way that indicates an impact on the central nervous system.

18 Feb 2016

Researchers make some progress in determining causes for glioblastoma multiforme

A research team, with the participation of the University of Granada (UGR), has made some progress in determining the causes for glioblastoma multiforme (GBM), one of the most aggressive brain tumors known, to be resistant to the drugs currently used, which is one of the main limitations of its treatment.

18 Feb 2016

Antibiotics may be linked to delirium and other brain problems

Antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems, more than previously thought, according to a "Views and Reviews" article published in the February 17, 2016, online issue of Neurology, a medical journal of the American Academy of Neurology.

18 Feb 2016

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

A small peptide dubbed TAxI is living up to its name. Recent studies show it to be an effective vehicle for shuttling functional proteins, such as active enzymes, into the spinal cord after a muscle injection.

17 Feb 2016

Study: Delirium, muscle weakness and other neurological complications of sepsis poorly understood

Delirium, muscle weakness and other neurological complications of sepsis often are overlooked and poorly understood, according to a study published in the journal Current Neurology and Neurosciences Reports.

16 Feb 2016

Researchers identify how Toxoplasma parasite crosses blood-brain barrier

An estimated 30 percent of the world's population is chronically infected with the parasite Toxoplasma gondii. Most people live with the infection without noticeable effect, but it can be life-threatening for people with suppressed immune systems, such as people on cancer therapies or who have HIV/AIDS.

16 Feb 2016

Multimodal MRI recommended to prevent brain mass misdiagnosis

T2*-weighted gradient recalled echo or susceptibility-weighted imaging sequences should be performed during the diagnosis of brain masses to rule out pseudotumoural presentation of cerebral amyloid angiopathy-related inflammation, say researchers.

12 Feb 2016

Modulation of opioid system may improve effectiveness of drugs for treatment-resistant depression

A clinical trial of an experimental drug for treatment-resistant major depression finds that modulation of the endogenous opioid system may improve the effectiveness of drugs that target the action of serotonin and related monoamine neurotransmitters.

12 Feb 2016

Boosting intrinsic growth programs can enhance axon regeneration of injured neurons

Damage to axons in the central nervous system (CNS) typically results in permanent functional deficits. Boosting intrinsic growth programs can dramatically augment the axon regeneration of injured neurons. If injured neurons can regenerate sufficient number of axons, the CNS may recover and overcome such functional deficits.

11 Feb 2016

ESCMID gathers more solid data to better assess Zika virus risks, prepares for possible outbreak in Africa, Europe

Experts at the European Society of Clinical Microbiology and Infectious Diseases – an organization promoting research, risk assessment, knowledge sharing and best practices in the fight against infectious diseases – are developing tools to monitor the spread of the Zika virus and are conducting research to gather more solid data to better assess the risks associated with the infection.

10 Feb 2016

Older people could be at greater risk for negative consequences of consuming high-salt diet

Aging is associated with a number of changes that cause the body to function less efficiently, including the way the body controls water and sodium levels. Research has shown that as humans and animals age, they are less able to regulate sodium and water retention, urine concentration and thirst compared to their younger counterparts.

9 Feb 2016

Taste deficits appear to be more prevalent in MS patients

Taste deficits appear to be more prevalent among multiple sclerosis (MS) patients than previously reported and correlate with brain lesions left by the debilitating disease, a new study from the University of Pennsylvania's Smell and Taste Center and the department of Radiology found.

9 Feb 2016

Central Nervous System News and Research

Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Gamma Knife and RapidArc equally effective at eradicating cancer in the brain

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

Longer, more intense period of rehabilitation may boost recovery after stroke or traumatic injury

New CODMAN ENTERPRISE 2 Vascular Reconstruction Device launched for treatment of intracranial aneurysms

UCLA-led researchers identify specific gene network that promotes repair in peripheral nervous system

Wearable robotic exoskeleton may enable multiple sclerosis patients to walk more efficiently

Study provides new insights into Retigabine drug

Commonly used chemo toxins damage eyesight in childhood cancer survivors

Researchers make some progress in determining causes for glioblastoma multiforme

Antibiotics may be linked to delirium and other brain problems

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

Study: Delirium, muscle weakness and other neurological complications of sepsis poorly understood

Researchers identify how Toxoplasma parasite crosses blood-brain barrier

Multimodal MRI recommended to prevent brain mass misdiagnosis

Modulation of opioid system may improve effectiveness of drugs for treatment-resistant depression

Boosting intrinsic growth programs can enhance axon regeneration of injured neurons

ESCMID gathers more solid data to better assess Zika virus risks, prepares for possible outbreak in Africa, Europe

Older people could be at greater risk for negative consequences of consuming high-salt diet

Taste deficits appear to be more prevalent in MS patients

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