Mouse Model News and Research

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New textbook on mysterious and deadly cytokine storm syndrome

There's no telling where the call will come from, or when. But Randy Cron, M.D., Ph.D., professor of pediatrics and medicine at UAB, knows to expect them.

11 Nov 2019

Impaired liver function during pregnancy can lead to impaired metabolism and weight gain

Impaired liver function during pregnancy may alter gut bacteria composition and increase the risk of obesity in children, according to results presented at The Society for Endocrinology Annual Conference.

11 Nov 2019

Finding ways to stop cancer at its roots

Why do some cancers come back? Sometimes, a treatment can effectively eliminate cancer cells to undetectable levels, but, if the treatment stops, cancer may return.

7 Nov 2019

New vaccine strategy shows promise against HIV

A collaborative team of scientists has made a successful proof-of-principle demonstration of an advanced HIV vaccine strategy--an approach that may also work in protecting people from an array of other deadly infectious diseases.

7 Nov 2019

Liposomes cross blood brain barrier, could get healing drugs to stroke-affected brain

A new study from University of Manchester researchers, published in ACS Neuro, shows a high possibility of treating stroke patients using very small cell sacs called liposomes to bypass the blood brain barrier and carry lifesaving drugs to the brain to prevent damage following a stroke.

7 Nov 2019

Improved gene editing technique can successfully cut out undesirable genetic information

City of Hope researchers may have found a way to sharpen the fastest, cheapest and most accurate gene editing technique, CRISPR-Cas9, so that it can more successfully cut out undesirable genetic information.

7 Nov 2019

Early sound exposure can help treat hypersensitivity to noise associated with FXS

A research team at the University of California, Riverside, has found exposure to sound -- not sound reduction -- during early development of mice engineered to have Fragile X Syndrome, or FXS, restores molecular, cellular, and functional properties in the auditory cortex, the area of the brain that processes sounds.

6 Nov 2019

Novel mouse model can help monitor kidney disease progression and perform drug screening

Chronic kidney disease affects 750 million people each year. Aging populations and an increase in diseases such as diabetes will lead to a greater burden of kidney disease.

6 Nov 2019

Tumor cell plasticity counts during cancer metastasis

Cancer metastasis, which is the propagation of tumor cells into distant organs, is the leading cause of cancer patient mortality.

5 Nov 2019

Researchers develop new type of transposase protein with improved biochemical properties

The team, comprising researchers from the European Molecular Biology Laboratory, the Universitätsklinikum Würzburg and the Paul-Ehrlich-Institut, managed to design a new variant of the Sleeping Beauty transposase with dramatically improved biochemical properties.

4 Nov 2019

Some skin cancers originate in hair follicles, says new study

A new study published online in Nature Communicationson November 4, 2019, reports that some melanomas, which are among the deadliest skin cancers, originate in melanocyte stem cells that are located within the hair follicles.

4 Nov 2019

Study describes a molecular strategy that helps prevent development of tumors in mice

The body's process for manufacturing fatty acids is regulated by the enzyme FASN. In normal cells, this is not a very active process - except occasionally in the liver and adipose tissue - since most of the fatty acids we need for cell maintenance are obtained from the diet.

4 Nov 2019

Some deadly skin cancers may originate in hair follicles

Some deadly skin cancers may originate in the pigment-making stem cells in hair follicles rather than in skin.

4 Nov 2019

Some skin cancers may originate in hair follicles

Some of the most deadly skin cancers may start in stem cells that lend color to hair, and originate in hair follicles rather than in skin layers, a new study finds.

4 Nov 2019

Study identifies a kinase as potential target to treat heart failure

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies.

31 Oct 2019

Scientists receive $1.6 million grant to study impact of phthalate exposure on male fertility

A cross-disciplinary team of scientists, led by University of Massachusetts Amherst environmental epigeneticist Richard Pilsner, will use a three-year, $1.6 million grant from the National Institute of Environmental Health Sciences to expand research into the impact of phthalate exposure on male fertility.

30 Oct 2019

Mouse Model News and Research

New textbook on mysterious and deadly cytokine storm syndrome

Impaired liver function during pregnancy can lead to impaired metabolism and weight gain

Finding ways to stop cancer at its roots

New vaccine strategy shows promise against HIV

Liposomes cross blood brain barrier, could get healing drugs to stroke-affected brain

Improved gene editing technique can successfully cut out undesirable genetic information

Early sound exposure can help treat hypersensitivity to noise associated with FXS

Novel mouse model can help monitor kidney disease progression and perform drug screening

Tumor cell plasticity counts during cancer metastasis

Researchers develop new type of transposase protein with improved biochemical properties

Some skin cancers originate in hair follicles, says new study

Study describes a molecular strategy that helps prevent development of tumors in mice

Some deadly skin cancers may originate in hair follicles

Some skin cancers may originate in hair follicles

Study identifies a kinase as potential target to treat heart failure

Scientists receive $1.6 million grant to study impact of phthalate exposure on male fertility

Humanized skin model answers questions about transient carriers of MRSA

Biotin synthesis is a novel target for antibiotics

Bortezomib drug helps re-balance disrupted muscle growth, prevent contractures

How the SETD1A gene produces schizophrenia in mice

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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