Mouse Model News and Research

RSS

New finding could become glioblastoma’s Achilles heel

Glioblastoma is the most frequent and aggressive brain cancer due to its ability to escape the immune system. However, the way in which this tumor manages to induce this immune tolerance was not known in detail.

23 Sep 2019

Alzheimer’s drug an interesting candidate for the treatment of parasitic Chagas disease

Researchers have discovered that an Alzheimer's drug could serve as a starting point in treating Chagas disease.

20 Sep 2019

Mitochondrial fission factor could represent a promising target for cancer therapy

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types.

20 Sep 2019

Stem cells with 'dual identity' associated with loss of smell from inflammation in chronic sinusitis

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis.

19 Sep 2019

Psoriasis drug could be repurposed to treat osteosarcoma

A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings from the Garvan Institute of Medical Research suggest.

18 Sep 2019

Compound could play a novel role in halting spread of pancreatic cancer

In early test tube and mouse studies, investigators at Johns Hopkins Medicine and the Johns Hopkins Kimmel Cancer Center have found that nonmuscle myosin IIC (MYH14), a protein activated in response to mechanical stress, helps promote metastatic behavior in pancreatic cancer cells, and that the compound 4-hydroxyacetophenone (4-HAP), known to stiffen myosin IIC-containing cells, can send it into overdrive, overwhelming the ability of cells to invade nearby tissue.

18 Sep 2019

Genetic mutation appears to help people fight off MRSA

Researchers have discovered that people who carry a certain genetic mutation may have a greater chance of fighting off MRSA infections.

18 Sep 2019

Study: Gene editing may correct genetic mutation responsible for Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments.

18 Sep 2019

Scientists pinpoint cause of fatal genetic disorder in children

Scientists at Washington University School of Medicine in St. Louis appear to have solved a decades-long mystery regarding the precise biochemical pathway leading to a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3.

17 Sep 2019

Researchers identify potential target for diabetes-associated Alzheimer's disease

Researchers have identified a protein that may contribute to the progression of Alzheimer’s disease pathology in type-2 diabetes, reports a new study of male mice and human brain tissue. The research could have implications for future drug development.

From Society for Neuroscience 17 Sep 2019

Dengue fever is endemic in places where iron deficiency is more common

Mosquitoes are more likely to acquire the dengue virus when they feed on blood with low levels of iron, researchers report in the 16 September issue of Nature Microbiology.

16 Sep 2019

Bone marrow cells contribute to pregnancy success in mouse model

Scientists report that stem cells derived from the adult bone marrow can dictate whether a woman becomes pregnant.

13 Sep 2019

Cancer disease incidence and severity influenced by gene mutation, tissue location

The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have a mutated KRAS gene, or oncogene, that is at least partially responsible for cancer development.

12 Sep 2019

Study identifies inhibitor that protects cells from toxic DUX4 effects

About one in 8,000 people have facioscapulohumeral muscular dystrophy, according to a 2014 study, which is relatively common in the world of genetic diseases.

11 Sep 2019

Researchers identify mechanism responsible for spatial issues in people with Down syndrome

Researchers reveal that an imbalance of gene Grik1 is behind the spatial issues that people with Down syndrome experience.

11 Sep 2019

Cell adhesion protein promotes metastasis in breast cancer, study reveals

Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis.

From Johns Hopkins Medicine 11 Sep 2019

'Protein mapping' approach reveals why metastatic melanoma patients do not respond to immunotherapy

Tel Aviv University and Sheba Medical Center researchers say they have discovered why more than half of patients with metastatic melanoma do not respond to immunotherapy cancer treatments.

10 Sep 2019

Researchers investigate how to prevent the onset of schizophrenia using mouse model

Although predisposing processes occur earlier, schizophrenia breaks out at young adulthood, suggesting it might involve a pathological transition during late brain development in predisposed individuals.

9 Sep 2019

Researchers develop new cocktail of drugs that shrink pancreatic tumors

Cancer is relentless and resilient. When a drug blocks a cancer cell's main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called "developing resistance," and it's one of the key challenges researchers face when seeking effective therapeutics to combat pancreatic ductal adenocarcinoma (PDA).

9 Sep 2019

VUMC partners with Batavia to move promising Zika antibody therapy closer to the clinic

Researchers at Vanderbilt University Medical Center are partnering with the Dutch biopharmaceutical firm Batavia Biosciences and Nashville-based IDBiologics to bring to the clinic a highly potent Zika virus neutralizing antibody they isolated three years ago.

6 Sep 2019

Mouse Model News and Research

New finding could become glioblastoma’s Achilles heel

Alzheimer’s drug an interesting candidate for the treatment of parasitic Chagas disease

Mitochondrial fission factor could represent a promising target for cancer therapy

Stem cells with 'dual identity' associated with loss of smell from inflammation in chronic sinusitis

Psoriasis drug could be repurposed to treat osteosarcoma

Compound could play a novel role in halting spread of pancreatic cancer

Genetic mutation appears to help people fight off MRSA

Study: Gene editing may correct genetic mutation responsible for Duchenne muscular dystrophy

Scientists pinpoint cause of fatal genetic disorder in children

Researchers identify potential target for diabetes-associated Alzheimer's disease

Dengue fever is endemic in places where iron deficiency is more common

Bone marrow cells contribute to pregnancy success in mouse model

Cancer disease incidence and severity influenced by gene mutation, tissue location

Study identifies inhibitor that protects cells from toxic DUX4 effects

Researchers identify mechanism responsible for spatial issues in people with Down syndrome

Cell adhesion protein promotes metastasis in breast cancer, study reveals

'Protein mapping' approach reveals why metastatic melanoma patients do not respond to immunotherapy

Researchers investigate how to prevent the onset of schizophrenia using mouse model

Researchers develop new cocktail of drugs that shrink pancreatic tumors

VUMC partners with Batavia to move promising Zika antibody therapy closer to the clinic

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News