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‘Rogue’ DNA rings identified as drivers of aggressive brain cancer

An international team of scientists has revealed how rogue rings of DNA that float outside of our chromosomes – known as extrachromosomal DNA, or ecDNA – can drive the growth of a large proportion of glioblastomas, the most common and aggressive adult brain cancer.

9 Sep 2025

Common diabetes drug metformin cuts long covid risk by 64 percent in UK study

A large UK-based retrospective cohort study found that initiating metformin within 90 days of COVID-19 diagnosis reduced the risk of Long COVID by 64% in overweight and obese adults. The findings suggest metformin may offer a low-cost preventive option pending confirmation from randomized trials.

8 Sep 2025

Mushrooms deliver nutrition medicine and sustainability solutions in one package

This Food Science & Nutrition review highlights mushrooms as nutrient-rich functional foods packed with bioactive compounds that support human health. It explores their therapeutic, industrial, and environmental applications, from disease prevention and drug discovery to bioremediation and bioenergy.

8 Sep 2025

New strategy for difficult-to-treat mesothelioma: Immunotherapy and ctDNA insights

People with operable diffuse pleural mesothelioma may benefit from immunotherapy before and after surgery, based on results of a clinical trial exploring the sequence of treatment and the role of surgery for this difficult to treat cancer.

8 Sep 2025

Tarlatamab and anti-PD-L1 therapy combination demonstrates manageable safety profile in first-line ES-SCLC

Clinical data presented today demonstrates the combination of tarlatamab with anti-PD-L1 therapy as first-line maintenance has an acceptable safety profile and resulted in unprecedented overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC).

8 Sep 2025

Ifinatamab deruxtecan may benefit patients with recurrent or progressive ES-SCLC

Patients diagnosed with recurrent or progressive extensive-stage small cell lung cancer (ES-SCLC) may benefit from treatment with ifinatamab deruxtecan (I-DXd), a B7-H3–directed antibody–drug conjugate, according to data presented today at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.

8 Sep 2025

New hydrogel may help alleviate negative impacts of menopause

A new hydrogel applied directly to vaginal tissues may help alleviate the negative impacts of menopause, according to a new study from scientists at the University of California San Diego.

8 Sep 2025

Aspirin therapy does not help people suffering from chronic rhinosinusitis with nasal polyps

A randomized placebo-controlled Finnish study showed that aspirin therapy does not provide significant relief for people suffering from chronic rhinosinusitis with nasal polyps who are hypersensitive to non-steroidal anti-inflammatory drugs (NSAIDs).

8 Sep 2025

Osimertinib plus chemotherapy offers overall survival advantage for patients with EGFR-mutated advanced NSCLC

Final overall survival (OS) results from the Phase III FLAURA2 trial demonstrate that first-line osimertinib plus chemotherapy significantly improves OS compared to osimertinib monotherapy in patients with EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC).

8 Sep 2025

Ivonescimab plus chemotherapy provides survival benefit for difficult-to-treat NSCLC patients

Adding ivonescimab, a first-in-class bispecific antibody targeting both PD-1 and VEGF, to chemotherapy significantly prolonged progression-free survival (PFS) compared to chemotherapy alone in patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations whose disease progressed on third-generation EGFR tyrosine kinase inhibitors (TKIs).

8 Sep 2025

Sleep medications linked to reduced deep sleep and disrupted memory

Long-term benzodiazepine use in older adults disrupts sleep patterns, leading to lighter sleep and potential cognitive decline due to altered brain activity.

8 Sep 2025

Ultrasound device enables precise non-invasive stimulation of deep brain regions

An ultrasound device that can precisely stimulate areas deep in the brain without surgery has been developed by researchers from UCL and the University of Oxford, opening up new possibilities for neurological research and treatment of disorders such as Parkinson's disease.

5 Sep 2025

WHO expands essential medicines lists with new cancer and diabetes treatments

Today, the World Health Organization (WHO) has released updated editions of its Model Lists of Essential Medicines (EML) and Essential Medicines for Children (EMLc), adding new treatments for various types of cancer and for diabetes with associated comorbidities such as obesity.

5 Sep 2025

Streamlining CAR T cell production through in vivo therapeutic strategies

This review article highlights the transformative potential of in vivo CAR T cell therapy in addressing the limitations of traditional CAR T cell production.

5 Sep 2025

Adding progesterone to gender-affirming hormone therapy improves breast growth for transgender people

The addition of the hormone progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender people following feminising hormone therapy.

5 Sep 2025

Targeting ADAR1 offers new hope against glioblastoma

The most common and aggressive type of adult brain cancer, glioblastoma multiforme (GBM) is notoriously resistant to treatment, with a median survival of just 14 months following diagnosis.

5 Sep 2025

Portable ultrasound improves diagnosis and patient outcomes

When hospitalized patients struggle to breathe, doctors typically reach for their stethoscopes, but results from a Rutgers and RWJBarnabas Health clinical study in JAMA Network Open suggest they should diagnose the problem with portable ultrasounds instead.

5 Sep 2025

Therapy News and Research

‘Rogue’ DNA rings identified as drivers of aggressive brain cancer

Common diabetes drug metformin cuts long covid risk by 64 percent in UK study

Mushrooms deliver nutrition medicine and sustainability solutions in one package

New strategy for difficult-to-treat mesothelioma: Immunotherapy and ctDNA insights

Tarlatamab and anti-PD-L1 therapy combination demonstrates manageable safety profile in first-line ES-SCLC

Ifinatamab deruxtecan may benefit patients with recurrent or progressive ES-SCLC

New hydrogel may help alleviate negative impacts of menopause

Aspirin therapy does not help people suffering from chronic rhinosinusitis with nasal polyps

Osimertinib plus chemotherapy offers overall survival advantage for patients with EGFR-mutated advanced NSCLC

Ivonescimab plus chemotherapy provides survival benefit for difficult-to-treat NSCLC patients

Sleep medications linked to reduced deep sleep and disrupted memory

Ultrasound device enables precise non-invasive stimulation of deep brain regions

WHO expands essential medicines lists with new cancer and diabetes treatments

Streamlining CAR T cell production through in vivo therapeutic strategies

Adding progesterone to gender-affirming hormone therapy improves breast growth for transgender people

Targeting ADAR1 offers new hope against glioblastoma

Portable ultrasound improves diagnosis and patient outcomes

Targeting the lysosome-iron-mitochondria axis for osteoporosis therapy

New guidelines for managing interstitial lung disease associated with connective tissue diseases

Semaglutide may one day be used to treat cocaine addiction

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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