Transplant News and Research

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Successful delivery after womb transplant

A Brazilian woman became the first woman to successfully deliver a baby after having received a womb transplant from a dead donor.

4 Dec 2018

Study: 39% of B cell lymphoma patients treated with CAR T therapy remain in remission

A new article published today in The Lancet Oncology shows 39 percent of large B cell lymphoma patients treated with the chimeric antigen receptor T-cell therapy Yescarta remained in remission more than two years following therapy, and more than half of the patients treated remain alive.

4 Dec 2018

New gene therapy treatment for Sickle Cell Anemia reverses symptoms in adults

After over a decade of preclinical research and development, a new gene therapy treatment for Sickle Cell Anemia is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common.

3 Dec 2018

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

Chimeric antigen receptor T-cell therapy, or CAR T, was named the 2017 Advance of the Year by the American Society of Clinical Oncology. The FDA approved two CAR T products last year for treatment of adult large B-cell lymphoma based on the exceptional patient outcomes seen in clinical trials.

3 Dec 2018

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

More than 30 abstracts presented at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego, December 1-4, featured research highlighting the ability of Bio-Rad's Droplet Digital PCR to provide high sensitivity and accuracy in quantifying minimal residual disease -- those remaining cancer cells after therapy that are associated with relapse -- in blood diseases such as leukemia.

3 Dec 2018

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

At the American Society of Hematology Annual Meeting, Cleveland Clinic medical hematologist and oncologist Aziz Nazha, M.D., will present results of a personalized prediction model that surpassed current prediction models for Myelodysplastic Syndromes.

3 Dec 2018

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

FDA approves new combination therapy for acute myeloid leukemia

Older patients with acute myeloid leukemia (AML) often aren't healthy enough to receive intensive chemotherapy, and gentler treatments aren't very effective in treating this aggressive blood cancer.

30 Nov 2018

Study points toward new strategies for managing organ transplantation

The human intestine may provide up to 10 percent of blood cells in circulation from its own reservoir of blood-forming stem cells, a surprising new study from researchers at Columbia University Vagelos College of Physicians and Surgeons has found.

30 Nov 2018

Researchers map cells in the early human placenta to shed light on pregnancy complications

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to date has focused on those later stages of pregnancy. But the biological events that lead to these problems could start much earlier.

28 Nov 2018

New therapeutic drug monitoring service could benefit children with cancer

Children with cancer are to benefit nationally from a service which for the first time will allow doctors to personalize their treatment.

28 Nov 2018

Japan-India collaboration results in new treatment approach for male urethral stricture

A novel and relatively pain-less treatment method for male urethral stricture using patients own buccal mucosal cells has been reported as successful in four out of six patients.

25 Nov 2018

Myriad biological, societal factors that impact CKD severity for children of African descent

Myriad biological and societal factors can impact the occurrence and accelerate progression of chronic kidney disease for children of African descent - including preterm birth, exposure to toxins during gestation and lower socioeconomic status - and can complicate these children's access to effective treatments, according to an invited commentary published in the November 2018 edition of American Journal of Kidney Diseases.

21 Nov 2018

Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising

The scene is shadowy, and the background music foreboding. On the TV screen, a stream of beleaguered humans stand in an unending line.

19 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018

Obesity significantly increases risk of Type 2 diabetes and coronary artery disease

A Cleveland Clinic genetic analysis has found that obesity itself, not just the adverse health effects associated with it, significantly increases the risk of Type 2 diabetes and coronary artery disease. The paper was published today in the Journal of the American Medical Association Network Open.

17 Nov 2018

New first-line treatment for peripheral T-cell lymphoma approved by FDA

The U.S. Food and Drug Administration today expanded the approved use of Adcetris (brentuximab vedotin) injection in combination with chemotherapy for adult patients with certain types of peripheral T-cell lymphoma.

16 Nov 2018

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalized treatment in the future.

16 Nov 2018

Infant gut microbes altered by mother's obesity may increase risk for future disease

Infant gut microbes altered by their mother's obesity can cause inflammation and other major changes within the baby, increasing the risk of obesity and non-alcoholic fatty liver disease later in life, according to researchers at the University of Colorado Anschutz Medical Campus.

16 Nov 2018

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom.

16 Nov 2018

Transplant News and Research

Successful delivery after womb transplant

Study: 39% of B cell lymphoma patients treated with CAR T therapy remain in remission

New gene therapy treatment for Sickle Cell Anemia reverses symptoms in adults

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

FDA approves new combination therapy for acute myeloid leukemia

Study points toward new strategies for managing organ transplantation

Researchers map cells in the early human placenta to shed light on pregnancy complications

New therapeutic drug monitoring service could benefit children with cancer

Japan-India collaboration results in new treatment approach for male urethral stricture

Myriad biological, societal factors that impact CKD severity for children of African descent

Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

Obesity significantly increases risk of Type 2 diabetes and coronary artery disease

New first-line treatment for peripheral T-cell lymphoma approved by FDA

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

Infant gut microbes altered by mother's obesity may increase risk for future disease

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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