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Majority of patients who misuse drugs and alcohol have chronic pain

With opioid addiction and prescription drug abuse considered one of the biggest public health threats of our time in the U.S., many are asking why so many Americans are struggling with addiction to illegal drugs and prescription medications. New research suggests that chronic pain may be part of the answer.

10 May 2016

Scientists discover new genetic information about development of breast cancer

SCIENTISTS have unearthed crucial new genetic information about how breast cancer develops and the genetic changes which can be linked to survival, according to a Cancer Research UK-funded study published in Nature Communications today (Tuesday).

10 May 2016

Study highlights role of specific chromosomal deletion in cancer development, progression

In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to reveal through the study of individual genes. Prof. Anna Sablina and her team at VIB/KU Leuven optimized a workflow for the generation of cell lines with targeted chromosomal deletions.

10 May 2016

Mindfulness-based cognitive therapy more beneficial without antidepressant drugs

An investigation published in the current issue of Psychotherapy and Psychosomatics indicates that mindfulness based cognitive therapy (MBCT) is most helpful when antidepressant drugs are not used.

10 May 2016

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

St. Jude Children's Research Hospital scientists report the first evidence that a pathogen-specific antibiotic was less disruptive to the gut microbiome than broad-spectrum antibiotics.

10 May 2016

Experimental therapy stops glioblastoma, high-grade gliomas in human cells and mouse models

Researchers report in the journal Cancer Cell an experimental therapy that in laboratory tests on human cells and mouse models stops aggressive, treatment-resistant and deadly brain cancers called glioblastoma and high-grade gliomas.

10 May 2016

TSRI scientists design potential drug candidate to treat triple negative breast cancer

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer.

10 May 2016

CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

Stroke and Alzheimer's disease are major diseases imposing a huge burden on aging societies. It has long been recognized that stroke and Alzheimer's disease often co-occur, and it has been speculated that the two disorders have an overlapping pathogenesis.

10 May 2016

UCLA study shows anti-nausea drug does not increase risk of birth defects

Women suffering from extreme morning sickness often take Zofran (ondansetron) to combat their debilitating nausea and vomiting. However, two studies have found that the drug may increase risk of heart defects and cleft palate in children exposed in utero.

10 May 2016

New study finds link between prenatal SSRI use and umbilical cord length

Umbilical cords of children whose mothers used selective serotonin reuptake inhibitors during pregnancy may be longer than umbilical cords of other newborn children, shows a new study from the University of Eastern Finland and Kuopio University Hospital. Selective serotonin reuptake inhibitors, SSRIs, are commonly prescribed antidepressants, and this is the first time their association with umbilical cord length was observed.

9 May 2016

Researchers find way to selectively deliver drugs to placenta without harming fetus

Nearly 10 percent of babies born in the United States are born premature, according to the March of Dimes. The underlying cause of many complications during pregnancy is often a poorly functioning placenta, the organ that nourishes and maintains the fetus.

9 May 2016

Study shows testosterone replacement therapy does not increase risk for prostate cancer

Men with low levels of the male sex hormone testosterone need not fear that testosterone replacement therapy will increase their risk of prostate cancer.

9 May 2016

Minihepcidins may potentially treat serious genetic blood diseases in children, adults

New research suggests that synthetic peptides called minihepcidins may potentially treat two serious genetic blood diseases in children and adults. Although those diseases, beta-thalassemia and polycythemia vera, have opposite effects on red blood cell production, treating animals with minihepcidin helps to restore normal levels of red blood cells and reduces spleen enlargement. It also controls the accumulation of excess levels of iron in beta-thalassemia that often causes severe toxic effects.

9 May 2016

Adolescent behavior expert suggests early screening to assess teenagers at vaping risk

During a checkup, physicians and nurses often ask about drinking habits, safe sex practice or cigarette use. Vaping is rarely mentioned.

9 May 2016

New antibody-based therapy may provide better strategy for long-term control of HIV

The development of antiretroviral therapy, a combination of drugs that slows the replication of HIV in the body, has transformed the treatment of this infection. What was once a certain death sentence is now a chronic condition that people can live with for decades.

9 May 2016

FDA issues formal request to pharmacies to recall all drugs intended to be sterile from Medaus

The U.S. Food and Drug Administration is reminding health care professionals and patients not to use drugs intended to be sterile that were produced by Medaus Inc., due to lack of sterility assurance. The FDA has issued a formal request to the Birmingham, Alabama, compounding pharmacy to recall all non-expired lots of drug products intended to be sterile.

8 May 2016

Physicians come together for single-payer national health insurance reform

In a dramatic show of physician support for deeper health reform - and for making a decisive break with the private insurance model of financing medical care - 2,231 physicians called today [Thursday, May 5] for the creation of a publicly financed, single-payer national health program that would cover all Americans for all medically necessary care.

6 May 2016

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

A major type of inflammatory bowel disease (IBD) may be caused in part by genetic variants that prevent beneficial bacteria in the gut from doing their job, according to a new study published today in the journal Science.

6 May 2016

Women often excluded from type 2 diabetes drug trials

While women who are pregnant, or breastfeeding or who may become pregnant are often excluded from clinical trials for type 2 diabetes drugs, the exclusion is frequently not based on the risk of fetal harm, according to Penn State College of Medicine researchers and may be contributing to the underrepresentation of women in clinical trials and an incomplete understanding of the effects of drugs on women who become pregnant unexpectedly.

6 May 2016

Key protein involved in mitosis helps prevent abnormal distribution of chromosomes

A tension-sensitive "fail safe" protein helps make sure that when our cells divide the two resulting cells inherit the normal number of chromosomes, researchers from the University of Washington and the Fred Hutchinson Cancer Research Center report today, May 5, in the journal Cell.

6 May 2016

Drugs News and Research

Majority of patients who misuse drugs and alcohol have chronic pain

Scientists discover new genetic information about development of breast cancer

Study highlights role of specific chromosomal deletion in cancer development, progression

Mindfulness-based cognitive therapy more beneficial without antidepressant drugs

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

Experimental therapy stops glioblastoma, high-grade gliomas in human cells and mouse models

TSRI scientists design potential drug candidate to treat triple negative breast cancer

CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

UCLA study shows anti-nausea drug does not increase risk of birth defects

New study finds link between prenatal SSRI use and umbilical cord length

Researchers find way to selectively deliver drugs to placenta without harming fetus

Study shows testosterone replacement therapy does not increase risk for prostate cancer

Minihepcidins may potentially treat serious genetic blood diseases in children, adults

Adolescent behavior expert suggests early screening to assess teenagers at vaping risk

New antibody-based therapy may provide better strategy for long-term control of HIV

FDA issues formal request to pharmacies to recall all drugs intended to be sterile from Medaus

Physicians come together for single-payer national health insurance reform

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

Women often excluded from type 2 diabetes drug trials

Key protein involved in mitosis helps prevent abnormal distribution of chromosomes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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