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Booster vaccination maintains high efficacy against malaria in African children

Researchers from the University of Oxford and their partners have today reported new findings from their Phase 2b trial following the administration of a booster dose of the candidate malaria vaccine, R21/Matrix-M™ - which previously demonstrated high-level efficacy of 77% over the following 12 months in young west African children in 2021.

9 Sep 2022

Can preclinical COVID-19 models help unlock mystery of long-COVID?

In a recently published article in the journal PLOS PATHOGENS, scientists have summarized acute and prolonged clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review also provides an overview of the potency and utility of preclinical animal models to understand the mechanistic details of acute and long coronavirus disease 2019 (COVID-19).

8 Sep 2022

Clinical trial begins evaluating alternative strategies to administer the JYNNEOS monkeypox vaccine

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers.

8 Sep 2022

Plants and plant-derived preparations as co-treatments for COVID-19

A recent Journal of Medicinal Food study proposed a comprehensive guideline for applying plants and plant-derived formulations to co-treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and other viral infections.

8 Sep 2022

Scientists develop a model human gut microbiome

A team of US-based scientists has developed a novel bacterial community comprising 119 microbial species naturally found in the human body. The study is published in the journal Cell.

7 Sep 2022

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Researchers review current knowledge regarding the generation of immune memory responses and their durability post-infection and vaccination.

7 Sep 2022

Discovery sheds light on an important aspect of gut health and mucosal immunity

Immune cells called group 3 innate lymphoid cells (ILC3s) play an essential role in establishing tolerance to symbiotic microbes that dwell in the human gastrointestinal tract, according to a study led by researchers at Weill Cornell Medicine.

7 Sep 2022

First nasal vaccine for COVID-19 approved in India for emergency use

The world's first nasal vaccine for COVID-19 was approved Tuesday, Sept. 6, in India for emergency use. The vaccine, called iNCOVACC, is based on technology licensed from Washington University in St. Louis and developed in collaboration with Bharat Biotech International Limited in India.

7 Sep 2022

New method can accurately, quickly predict which antigens will lead to strong immune response

A cell's secrets can be divulged by its surface, decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe.

5 Sep 2022

New and unique technique to brain imaging has potential to save lives

Observing the brain without creating any breaks in the skull is an emerging technology for those studying various brain-related diseases.

5 Sep 2022

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Synexa is an industry-leading biomarker and large molecule bio analytic research service provider. In this interview, NewsMedical speaks with Natalie Strickland, a principal scientist at Synexa, about alternative approaches to flow cytometry.

From Synexa Life Sciences 5 Sep 2022

Bats pose little zoonotic danger to humans, study says

A new Tel Aviv University study rejects assertions, according to which the origin of the COVID-19 outbreak is in bats. According to the study, bats have a highly effective immune system that enables them to deal relatively easily with viruses considered lethal for other mammals.

5 Sep 2022

MHRA approves bivalent COVID-19 booster vaccine made by Pfizer/BioNTech

A second, "bivalent" vaccine has today been approved as a booster by the Medicines and Healthcare products Regulatory Agency (MHRA) after it was found to meet the UK regulator's standards of safety, quality and effectiveness.

3 Sep 2022

Depletion of reactive astrocytes regresses glioblastoma

A groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cancer. The researchers achieved the outcome using a method they developed based on their discovery of two critical mechanisms in the brain that support tumor growth and survival: one protects cancer cells from the immune system, while the other supplies the energy required for rapid tumor growth. The work found that both mechanisms are controlled by brain cells called astrocytes, and in their absence, the tumor cells die and are eliminated.

2 Sep 2022