Vaccine boosters and breakthrough infections provide substantial immunity against COVID-19

NewsGuard 100/100 Score

Vaccine boosters and breakthrough infections following vaccination both provide a substantial and potentially pandemic-breaking immunity against COVID-19, according to new laboratory research from Oregon Health & Science University.

The study, published Wednesday in the journal Med, is the latest in a series of OHSU discoveries using blood samples to characterize immune response to the SARS-CoV-2 virus.

"As the number of omicron subvariant cases rise and as global vaccination and booster campaigns continue, an increasing proportion of the world's population will acquire potent immune responses that may be protective against future SARS-CoV-2 variants," the researchers conclude.

The research measured a powerful immune response among samples from 99 OHSU employees who had blood drawn for the research. Notably, researchers measured an equally potent immune response to the virus -; with dramatic increases in magnitude, potency and breadth -; among people whose blood was drawn three months after a third vaccine booster dose and another group one month after a breakthrough infection.

In addition, the study found the immune response was just as powerful among people 65 and older.

Early in the pandemic, we had very high mortality in certain vulnerable groups, such as older adults in nursing homes, but that reality is slowly changing. Our study bolsters the idea that vaccination is a pathway to a milder illness. Even if you're older, your chances of having a severe illness if you're re-infected down the line appears to be much lower than it was at the start of the pandemic."

Marcel Curlin, M.D., Co-Senior Author, Associate Professor of Medicine (infectious diseases), OHSU School of Medicine and Medical Director of OHSU Occupational Health

Co-senior author Fikadu Tafesse, Ph.D., associate professor of molecular microbiology and immunology in the OHSU School of Medicine, said he would expect an even more robust immune response among people receiving the new bivalent vaccine booster targeting the BA.4 and BA.5 variants.

"We anticipate that updated vaccine strategies with variant-specific regimens will significantly improve the breadth of the immune response and provide better protections against the SARS-CoV-2 variants," he said.

In contrast to the onset of the pandemic, the SARS-CoV-2 virus is no longer "novel" to the human immune system. Most people in the world have now been vaccinated, infected or both -; meaning the virus is running up against a much more effective immune response with each new infection.

Curlin said the new study most likely reflects the fact that the virus is evolving to become more transmissible but less harmful.

"Evolutionary pressure is driving the virus to find more ways to infect people at the cost of pathogenicity, most likely," he said. Pathogenicity refers to the capacity to cause symptoms associated with the disease.

Journal reference:

Curlin, M.E., et al. (2022) Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection. Med.


  1. Daniel O'Keefe Daniel O'Keefe United States says:

    It would be nice if the article offered what the outcome was when measuring a group of previously infected but unvaccinated so that the whole picture is clear. Since the vax wanes, what happens at the threshold between the two? There is not point in offering a suggestion of "powerful" or "ongoing" immunity if it depends on....ongoing vaccination....because that isn't immunity then, it is temporary protection....what happens at that line, for the previously infected, both vaxed and un-vaxed, when the vaccination wears off? Those are the numbers that matter going forward, especially for the population NOT in risk groups, that is, the majority.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study reveals high insomnia rates in non-hospitalized COVID-19 survivors